Pernicious anemia – Genetic insights

Banka, Siddharth; Ryan, Kate; Thomson, Wendy; Newman, William G.

doi:10.1016/j.autrev.2011.01.009

Cited by 35 publications

(25 citation statements)

References 51 publications

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“…Evidence for the role of genetic factors includes familial co-occurrence of PA and its association with other autoimmune diseases 22. Thus, a certain number of autoimmune diseases occur at a higher frequency in patients with PA – around 30% in the authors’ experience – or among family members of PA patients 4.…”

Section: Association With Other Autoimmune Diseasesmentioning

confidence: 86%

“…The association of PA with autoimmune diseases such as type 1 diabetes (insulin dependent), autoimmune thyroiditis (particularly Hashimoto’s thyroiditis), or vitiligo is common 2,22,23. Other associations have also been frequently described, eg, Sjogren’s syndrome, celiac disease, and Addison’s adrenal insufficiency 2,4,5.…”

Section: Association With Other Autoimmune Diseasesmentioning

confidence: 99%

“…With regard to susceptibility to PA, the role of the human leukocyte antigen system has been demonstrated for certain loci such as human leukocyte antigen B8 DR3 22,26. Nevertheless, data pertaining to genetic predisposition are still relatively fragmented, preliminary, and/or unconfirmed, eg, role of the AIRE gene.…”

Section: Association With Other Autoimmune Diseasesmentioning

confidence: 99%

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Optimal management of pernicious anemia

Andrès¹,

Serraj²

2012

JBM

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Pernicious anemia (also known as Biermer’s disease) is an autoimmune atrophic gastritis, predominantly of the fundus, and is responsible for a deficiency in vitamin B12 (cobalamin) due to its malabsorption. Its prevalence is 0.1% in the general population and 1.9% in subjects over the age of 60 years. Pernicious anemia represents 20%–50% of the causes of vitamin B12 deficiency in adults. Given its polymorphism and broad spectrum of clinical manifestations, pernicious anemia is a great pretender. Its diagnosis must therefore be evoked and considered in the presence of neurological and hematological manifestations of undetermined origin. Biologically, it is characterized by the presence of anti-intrinsic factor antibodies. Treatment is based on the administration of parenteral vitamin B12, although other routes of administration (eg, oral) are currently under study. In the present update, these various aspects are discussed with special emphasis on data of interest to the clinician.

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Section: Association With Other Autoimmune Diseasesmentioning

confidence: 86%

Section: Association With Other Autoimmune Diseasesmentioning

confidence: 99%

Section: Association With Other Autoimmune Diseasesmentioning

confidence: 99%

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Optimal management of pernicious anemia

Andrès¹,

Serraj²

2012

JBM

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“…First, H. pylori was found to be involved in various autoimmune diseases, including giant cell arteritis, systemic sclerosis and primary biliary cirrhosis 38. Other studies also reported the association between H. pylori and autoimmune bollous diseases 44 and pernicious anemia 45. Since autoimmune reaction is involved in UC pathogenesis, H. pylori may take effect through influencing this process.…”

Section: Discussionmentioning

confidence: 99%

Association between Helicobacter Pylori Infection and Ulcerative Colitis-A Case Control Study from China

Jin

Chen²,

Chen³

et al. 2013

Int. J. Med. Sci.

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Aims To investigate the association between H. pylori infection and UC prevalence in China. Materials and Methods Subjects were selected from patients admitted in Department of Gastroenterology for abdominal pain, hematochezia, diarrhea and other GI symptoms during 2009-2012. UC diagnosis was based on both colonoscopy and biopsy. H. pylori detection was based on 14C urea breath test (UBT) and biopsy sample culture. Patients' demographic, anthropometric and serologic data were selected. H. pylori infection rate was compared between UC and control groups, followed by a subgroup analysis on the association between H. pylori infection and extent and severity degree of UC. Results Totally, 153 and 121 patients were selected and divided into UC and control groups. There were no significant differences in age, gender, BMI, hypertension and diabetes. However, smoking history was significantly lower while WBC and CRP levels were significantly higher in UC group. The H. pylori infection rate in UC group was 30.5%, significantly lower than that of 57.0% in control group. The H. pylori infection rate in UC of left colon and whole colon were 33,9% and 24.2% (p<0.05 between them), both significantly lower than that in control group. In addition, the H. pylori infection rates in mild, moderate and severe UC subgroups were 37.8%, 32.3% and 22.2% (p>0.05 among them), all of which were significantly lower than that in control group. Conclusion We reported a significantly lower H. pylori infection rate in UC patients with different extent and severity degree, which provides evidence for bacteria involvement in UC pathogenesis and reminder clinicians to keep cautious in considering H. pylori eradication in UC patients.

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“…7 Second, its association with 2 haplotypes of the major histocompatibility complex type II has recently been reported: HLA-DRB1*03 and HLA-DRB*04. First, pernicious anemia has familial clustering; up to 19% of patients have a family member who is affected.…”

Section: What Causes It?mentioning

confidence: 98%