Pernicious Anemia and Atrophic Gastritis

Follow‐up Studies of Patients with Atrophic Gastritis

“…Accordingly, the atrophic changes were in many cases only patchy. Recently Glass et al (1) found a marked diminution of intrinsic factor secretion in patients with advanced atrophic changes of the gastric mucosa, thus confirming the results obtained by Siurala et al (2).…”

“…Six patients died during the observation period. The cause of death which was checked by means of inquiries, was gastric cancer ( l ) , thyroid cancer ( l ) , cancer of uterus ( l ) , myocardial infarction ( l ) , and operation for gastric ulcer (2). In the two patients operated on for gastric ulcer, histologic examination of the gastrectomy specimens showed no signs of malignancy.…”

Atrophic Gastritis as a Possible Precursor of Gastric Carcinoma and Pernicious Anemia Results of follow‐up examinations

“…Siurala et al (71) have previously stressed that many factors other than atrophic gastritis are involved in the development of pernicious anemia. I t has been noted that lack of intrinsic factor leading to pernicious anemia may occur chiefly in children and adolescentsin connection with a histologically normal gastric mucosa (10, 26, 51, 60, 61, 65).…”

“…Moreover, several studies with radiovitamin B,, indicate that atrophic gastritis might predispose to pernicious anemia (2,3,7,20,21,23,40,45,50,71,73,78). Siurala anemia and paticnts with different degrees of gastritis.…”

“…Siurala anemia and paticnts with different degrees of gastritis. They came to the conclusion that "nonspccific" atrophic gastritis might lead to deficiency of intrinsic factor and thereby possibly to pernicious anemia (71).…”