“…Accordingly, the atrophic changes were in many cases only patchy. Recently Glass et al (1) found a marked diminution of intrinsic factor secretion in patients with advanced atrophic changes of the gastric mucosa, thus confirming the results obtained by Siurala et al (2).…”
Section: Discussionsupporting
confidence: 72%
“…Six patients died during the observation period. The cause of death which was checked by means of inquiries, was gastric cancer ( l ) , thyroid cancer ( l ) , cancer of uterus ( l ) , myocardial infarction ( l ) , and operation for gastric ulcer (2). In the two patients operated on for gastric ulcer, histologic examination of the gastrectomy specimens showed no signs of malignancy.…”
“…Accordingly, the atrophic changes were in many cases only patchy. Recently Glass et al (1) found a marked diminution of intrinsic factor secretion in patients with advanced atrophic changes of the gastric mucosa, thus confirming the results obtained by Siurala et al (2).…”
Section: Discussionsupporting
confidence: 72%
“…Six patients died during the observation period. The cause of death which was checked by means of inquiries, was gastric cancer ( l ) , thyroid cancer ( l ) , cancer of uterus ( l ) , myocardial infarction ( l ) , and operation for gastric ulcer (2). In the two patients operated on for gastric ulcer, histologic examination of the gastrectomy specimens showed no signs of malignancy.…”
“…Siurala et al (71) have previously stressed that many factors other than atrophic gastritis are involved in the development of pernicious anemia. I t has been noted that lack of intrinsic factor leading to pernicious anemia may occur chiefly in children and adolescentsin connection with a histologically normal gastric mucosa (10, 26, 51, 60, 61, 65).…”
Section: Discussionmentioning
confidence: 99%
“…Moreover, several studies with radiovitamin B,, indicate that atrophic gastritis might predispose to pernicious anemia (2,3,7,20,21,23,40,45,50,71,73,78). Siurala anemia and paticnts with different degrees of gastritis.…”
mentioning
confidence: 99%
“…Siurala anemia and paticnts with different degrees of gastritis. They came to the conclusion that "nonspccific" atrophic gastritis might lead to deficiency of intrinsic factor and thereby possibly to pernicious anemia (71).…”
In many patients with low serum levels of vitamin B12, the absorption of the free vitamin has been normal. The present study, using a total body counter 57CoB12 absorption method that clearly separated those with intrinsic factor deficiency from controls, found that of 94 patients with low B12 levels and intact stomachs in whom the absorption of free and bound B12 was determined, 44 (47%) had normal absorption of both. However, 20 of the 94 (21%) with normal absorption of free B12 had low absorption of bound B12. The remainder (32%) had low absorption of both free and bound B12. All patients with high serum gastrin levels had low bound B12 absorption, but so did 21% of those patients with normal serum gastrin levels.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.