Pernasal versus Intravenous Administration of TRH: Effects on Thyrotropin, Prolactin, Triiodothyronine, Thyroxine and Thyroglobulin in Healthy Subjects

Schäfgen, W; Sf, Grebe; Schatz, H

doi:10.1055/s-2007-1018627

Cited by 17 publications

(9 citation statements)

References 3 publications

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“…The reason for this discrepancy may be a difference in the assay system, such as specificity of antibody TRH thus enters the blood stream. Recently, it has been reported that intranasal administration of TRH stimulates TSH, prolactin and T3 (Schäfgen et al 1983), in agreement with the present data. Plasma TSH, prolactin and thyroid hormone levels increased after rectal administration with an eleva¬ tion of plasma TRH concentrations, indicating that TRH administered through the rectal route stimu¬ lates the pituitary gland.…”

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

Changes in plasma thyrotrophin-releasing hormone, thyrotrophin, prolactin and thyroid hormone levels after intravenous, intranasal or rectal administration of synthetic thyrotrophin-releasing hormone in man

Mitsuma

Nogimori

1984

Acta Endocrinologica

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Changes in plasma thyrotrophin-releasing hormone (TRH), thyrotrophin (TSH), prolactin and thyroid hormone levels after iv, intranasal, or rectal administration of synthetic TRH were studied in man. The plasma TRH concentration increased with all three routes, but remained at higher levels for a longer time after intranasal or rectal administration, in contrast to the rapid decrease after iv administration. Plasma TSH, prolactin and thyroid hormone levels increased significantly after intranasal or rectal administration and also remained elevated for a longer period than iv administration.These findings suggest that TRH administered intranasally or rectally enters the blood stream and stimulates TSH, prolactin and thyroid hormone release in man.

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Section: Discussionsupporting

confidence: 93%

“…The effect of the route of administration on hormone release and plasma TRH concentra¬ tions however, has rarely been studied (Schäfgen et al 1983). THR has been used for the treatment of neurological and psychiatric disorders and iv ad¬ ministration is the usual route (Prange et al 1972;Kastin et al 1972;Huey et al 1975;Sobue et al 1980).…”

mentioning

confidence: 99%

Changes in plasma thyrotrophin-releasing hormone, thyrotrophin, prolactin and thyroid hormone levels after intravenous, intranasal or rectal administration of synthetic thyrotrophin-releasing hormone in man

Mitsuma

Nogimori

1984

Acta Endocrinologica

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“…Although the adverse reactions were not severe in our patients, they would have been probably more significant if we had not performed the test in the recumbent position. Also, the lying or half sitting position of the geriatric patients may explain the lower fre¬ quency of adverse reactions in our investigation series as compared with reported data (Vogt et al 1978;Schäfgen et al 1983;Schurr et al 1985;Staub et al 1985).…”

Section: Discussionsupporting

confidence: 52%

“…To answer this question we compared the effect of intravenous and intranasal TRH tests. The intravenous test is fast, exact doses can be given, but adverse reactions are more com¬ mon (56 vs 25% at nasal TRH application accord¬ ing to Schäfgen et al (1983), 77 versus 31% accord¬ ing to Schurr et al (1985)). The adverse reactions may be severe (Grussendorf et al 1982;Dolva et al 1983), and the injection must be given by a physican (or by skilled technicians or nurses under the supervision of the physican).…”

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confidence: 99%

Thyrotropin-releasing hormone in geriatric patients: intravenous versus intranasal application

Szabolcs¹,

Ploenes

Bernard

et al. 1989

Acta Endocrinologica

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The effect of intravenous versus intranasal TRH stimulation was compared in geriatric patients. In patients receiving both iv and nasal tests (N = 35) there was a good correlation between the TSH responses, but in 3 cases the suspicion of inadequate nasal TRH effect arose. The coefficient of correlation of basal to \g=D\TSHwas better in iv tested patients (116 patients in each group, one half having a positive the other half a negative TRH test). In the majority of patients with suspicious incongruity of basal and \g=D\TSH the nasal test was done. The specificity and sensitivity of various basal TSH 'cut-off' points to predict a positive TRH test were better in patients with iv TRH tests (in each group 96 consecutively admitted patients). Insufficiency of the nasal test in geriatric patients is mainly explained by the inability of the old people to aspirate the nasal spray effectively. Besides the advantages of iv TRH application in geriatric patients, the frequency of adverse reactions (14% versus 0%) must be considered. Thus, in a hospitalized geriatric patient, the TRH test should be performed iv in the recumbent position; however, for examination of geriatric outpatients the nasal test is recommended.

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“…An intranasally applicable TRH has been developed which appears to be active in normal adults (Schafgen et al, 1983). The aim of the present study was to establish the efficacy of this route of application and to compare its TSH-stimulatory capacity to the known effects of intravenous and oral TRH.…”

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confidence: 99%

Intranasal Thyrotrophin Releasing Hormone Is a Potent Stimulus for TSH Release in Man (Comparison With Intravenous and Oral Trh)

Staub

Ryff‐Delèche

Paul

et al. 1985

Clinical Endocrinology

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Intranasally administered TRH was tested and compared to i.v. and oral TRH in respect to its efficacy of TSH stimulation and thereby the stimulation of thyroid reserve. TSH release after nasal application is as prompt as after the i.v. route, reaching a peak at 20 to 30 min. After that, however, compared to the i.v. administration its stimulatory effect is prolonged, lasting over 3 h. At the dose used in this study the peak TSH response after intranasal TRH administration was 14.7 +/- 1.6 mU/l compared to 8.4 +/- 1.4 and 23.1 +/- 4.4 mU/l after i.v. and oral administration respectively (P less than 0.005). Intranasal application of TRH is as potent as i.v. or oral TRH for the stimulation of thyroid reserve. At 3 h a marked increase of T3 and a smaller elevation of FT4 is observed (delta T3 = 48.4%, delta FT4 = 31.6%). The nasal peptide was well tolerated locally and systemic side effects were comparable to those of i.v. TRH. This form of application offers a practical advantage by avoiding intravenous injections. Its diagnostic potential in investigation of thyroid disease and its possible therapeutic application have yet to be elucidated.

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Pernasal versus Intravenous Administration of TRH: Effects on Thyrotropin, Prolactin, Triiodothyronine, Thyroxine and Thyroglobulin in Healthy Subjects

Abstract: and T3 responses (x±SEM) to 400 M9 TRH i.v. o), 400 ug TRH p.n. (• •), 800 M9 TRH p.n. {*• A) and

Cited by 17 publications

References 3 publications

Changes in plasma thyrotrophin-releasing hormone, thyrotrophin, prolactin and thyroid hormone levels after intravenous, intranasal or rectal administration of synthetic thyrotrophin-releasing hormone in man

Changes in plasma thyrotrophin-releasing hormone, thyrotrophin, prolactin and thyroid hormone levels after intravenous, intranasal or rectal administration of synthetic thyrotrophin-releasing hormone in man

Thyrotropin-releasing hormone in geriatric patients: intravenous versus intranasal application

Intranasal Thyrotrophin Releasing Hormone Is a Potent Stimulus for TSH Release in Man (Comparison With Intravenous and Oral Trh)

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