Permutation tests for joinpoint regression with applications to cancer rates

Kim, Hyune Ju; Fay, Michael P.; Feuer, Eric J.; Midthune, Douglas

doi:10.1002/(sici)1097-0258(20000215)19:3<335::aid-sim336>3.0.co;2-z

Cited by 3,995 publications

(2,500 citation statements)

References 25 publications

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“…Time trends stratified by 10‐year age groups (20‐29, 30‐39, 40‐49, 50‐59 etc. ), age below and at/above screening age (20‐49, ≥50), sex, race, ethnicity, and subsite were analyzed using JoinPoint Regression Program (version 4.4.0.0, NCI),29, 30 which calculates annual percent changes (APCs) and identifies points in time when the APCs change in direction and/or velocity.…”

Section: Methodsmentioning

confidence: 99%

Trends in colorectal cancer incidence among younger adults—Disparities by age, sex, race, ethnicity, and subsite

et al. 2018

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Millennials (ages 18‐35) are now the largest living generation in the US, making it important to understand and characterize the rising trend of colorectal cancer incidence in this population, as well as other younger generations of Americans. Data from the New Jersey State Cancer Registry (n = 181 909) and Surveillance, Epidemiology, and End Results program (n = 448 714) were used to analyze invasive CRC incidence trends from 1979 to 2014. Age, sex, race, ethnicity, subsite, and stage differences between younger adults (20‐49) and screening age adults (≥50) in New Jersey (NJ) were examined using chi‐square; and, we compared secular trends in NJ to the United States (US). Whites, men, and the youngest adults (ages 20‐39) are experiencing greater APCs in rectal cancer incidence. Rates among younger black adults, overall, were consistently higher in both NJ and the US over time. When compared to older adults, younger adults with CRC in NJ were more likely to be: diagnosed at the late stage, diagnosed with rectal cancer, male, non‐white, and Hispanic. Invasive CRC incidence trends among younger adults were found to vary by age, sex, race, ethnicity, and subsite. Large, case‐level, studies are needed to understand the role of genetics, human papillomavirus (HPV), and cultural and behavioral factors in the rise of CRC among younger adults. Provider and public education about CRC risk factors will also be important for preventing and reversing the increasing CRC trend in younger adults.

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Section: Methodsmentioning

confidence: 99%

Trends in colorectal cancer incidence among younger adults—Disparities by age, sex, race, ethnicity, and subsite

et al. 2018

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“…2000; US National Institutes of Health, 2005). Age‐adjusted mortality rates were calculated in Joinpoint.…”

Section: Methodsmentioning

confidence: 99%

“…For each Sex/Year combination, there was a complete set of adjustment variable values: an Age variable in 5‐year age groups (35–39 years to 75–79 years), Count (number of deaths, nominator), Population (population at risk, denominator), and Standard Population (European standard population, 1976) (Kim et al. 2000). The standard population appeared on every data record and the value corresponded to the associated age group.…”

Section: Methodsmentioning

confidence: 99%

“…In the final best fitting model, each joinpoint informs a statistically significant change in trends (increase or decrease) and each of those trends is described by an APC (Kim et al. 2000; Yang et al. 2003).…”

Section: Methodsmentioning

confidence: 99%

“…The joinpoint regression model is useful for identifying and describing the occurrence of changes in different time periods throughout trends in data (Kim et al. 2000). The aim of this work is to assess changes in stroke mortality trends in Klaipeda (Lithuania) during the period of 1994–2013 using joinpoint regression models.…”

Section: Introductionmentioning

confidence: 99%

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Twenty years trends in mortality rates from stroke in Klaipeda

et al. 2016

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BackgroundDuring the past decades, mortality from stroke decreased in many western European countries; however, changes concerning long‐term stroke mortality in eastern European countries are less evident.ObjectiveTo assess age‐ and gender‐specific trends in stroke mortality in Klaipeda (Lithuania) from 1994 to 2013.DesignDescriptive epidemiological study.Setting/subjectsPermanent population of Klaipeda.MethodsData on 2509 permanent residents of Klaipeda aged 35–79 years who died from stroke between 1994 and 2013 were gathered. Directly, age‐standardized (European population) stroke mortality rates were analyzed using joinpoint regression separately for specific age groups (35–64, 65–79, and 35–79 years) and by gender. Annual percentage change (APC) and 95% CIs were presented.ResultsStroke mortality in the 35‐ to 79‐year‐old age group peaked in 1994–1997, it then decreased by −9.9% (95% CI: −18.7, −0.2) yearly up until 2001 and leveled off by −0.2% (−5.1, 4.9) between 2001 and 2013. Among men aged 35–64 years, mortality decreased substantially by 12.8% (−21.5, −3.3) per year from 1994 to 2001 and turned positive by 6.3% (0.8, 12.1) between 2000 and 2013. Among women aged 35–64 years, mortality decreased significantly by 15.5% (−28.1, −0.7) from 1994 to 2000. There was evidence of recent plateauing of trends for 35‐ to 64‐year‐old women between 2000 and 2013. In the 65‐ to 79‐year‐old age group, mortality decreased from 1994 onward yearly by −5.5% (−7.9, −3.0) in women and by −3.3% (−5.6, −0.9) in men.ConclusionsJoinpoint regression revealed steadily decreasing trend in stroke mortality between 1994 and 2001. The decline in death rates flattened out in the recent decade. Mortality rates varied among age groups and were more pronounced in adults aged 35–64 years. It is essential to monitor and manage stroke risk factors, especially among middle‐aged population.

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Increasing Rates of Melanoma Among Nonwhites in Florida Compared With the United States

Rouhani¹,

Pinheiro²,

Sherman³

et al. 2010

Arch Dermatol

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To compare melanoma trends within Florida with national melanoma trends from 1992 through 2004. An analysis of state and national melanoma trends is critical for the identification of high-risk regions of the country. Design: Data from the Florida Cancer Data System (FCDS) and Surveillance, Epidemiology, and End Results (SEER) were evaluated to determine age-adjusted and race/ethnicity-and sex-specific invasive cutaneous melanoma incidence trends for 1992 through 2004 using joinpoint regression analysis. Standardized incidence rate ratios (SIRRs) were computed to compare Florida with the United States. Patients: A population of 109 633 patients with invasive melanoma was evaluated: 73 206 (66.8%) from SEER and 36 427 (33.2%) from FCDS. Main Outcome Measures: Melanoma incidence and change in melanoma rates over time. Results: The incidence of melanoma among male Hispanic patients residing in Florida was 20% higher than that of their male counterparts in the SEER catchment areas (SIRR, 1.2; 95% confidence interval [CI], 1.1-1.4). Conversely, the incidence of melanoma among female Hispanic patients residing in Florida was significantly lower than that in SEER (SIRR, 0.7; 95% CI, 0.7-0.8). Differences in melanoma incidence were identified in female non-Hispanic black (NHB) patients in Florida who had a 60% significantly higher incidence of melanoma compared with female NHB patients in SEER (SIRR, 1.6; 95% CI, 1.3-2.0). Conclusion: These findings suggest an emerging public health concern in race/ethnic subgroups that were previously understudied.

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Permutation tests for joinpoint regression with applications to cancer rates

Cited by 3,995 publications

References 25 publications

Trends in colorectal cancer incidence among younger adults—Disparities by age, sex, race, ethnicity, and subsite

Trends in colorectal cancer incidence among younger adults—Disparities by age, sex, race, ethnicity, and subsite

Twenty years trends in mortality rates from stroke in Klaipeda

Increasing Rates of Melanoma Among Nonwhites in Florida Compared With the United States

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