Permethrin Versus Crotamiton and Lindane in the Treatment of Scabies

Amer, Mona G.; Elgharib, Ibrahim

doi:10.1111/j.1365-4362.1992.tb03958.x

Cited by 35 publications

(18 citation statements)

References 11 publications

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“…Crotamiton cream 10% is a drug that has been approved for the treatment of scabies in adults, but it is not approved for use in children. However, treatment failures have been documented with the use of crotamiton . Ivermectin is an antiparasitic agent approved for the treatment of worm infestations.…”

Section: Introductionmentioning

confidence: 99%

Topical ivermectin versus crotamiton cream 10% for the treatment of scabies

2014

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Scabies, known colloquially as the 7-year itch, is a contagious skin infection that occurs among humans and other animals. The treatment of choice is still controversial. The aim of this study was to compare the efficacy and safety of topical ivermectin vs. crotamiton cream 10% for the treatment of scabies. In total, 340 patients with scabies were enrolled, and randomized into two groups. The first group received 1% ivermectin applied topically to the affected skin. The dose employed was 400 μg/kg, repeated once the following week, and the second group received crotamiton 10% cream and were told to apply this twice daily for five consecutive days. Treatment was evaluated at intervals of two and four weeks, and if there was treatment failure at the 2-week follow-up, treatment was repeated. Two applications of topical ivermectin provided a cure rate of 64.7% at the 2-week follow-up, which increased to 82.3% at the 4-week follow-up after repeating the treatment. Treatment with single applications of crotamiton cream 10% was effective in 41.2% of patients at the 2-week follow-up, which increased to 64.7% at the 4-week follow-up after this treatment was repeated. Ivermectin was quite safe in our cases. Two applications of ivermectin were as effective as single applications of crotamiton 10% cream at the 2-week follow-up. After repeating the treatment, ivermectin was superior to crotamiton cream 10% at the 4-week follow-up.

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Section: Introductionmentioning

confidence: 99%

Topical ivermectin versus crotamiton cream 10% for the treatment of scabies

2014

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“…Crotamiton also had higher persistence of itching sensation after 4 weeks (24% vs 11%) and a higher incidence of secondary infection (38% vs 15%) than permethrin . There was no significant difference in terms of efficacy and safety in an RCT on 100 scabies patients comparing crotamiton 10% cream and 1% γ‐BHC . A report in Japan indicated a cure rate of 61.6% in children and 100% in adults after daily application of crotamiton 10% cream for 3 weeks in 39 children aged 3–5 years and in 12 adults .…”

Section: Treatment Of Scabiesmentioning

confidence: 96%

“…Two RCT (overnight application, application for 2 nights consecutively nights) were conducted comparing crotamiton 10% cream with permethrin 5% cream in 194 scabies patients. The cure rate after 4 weeks was 60% versus 89% in the former trial and 88% versus 98% in the latter trial, indicating that crotamiton had inferior efficacy.…”

Section: Treatment Of Scabiesmentioning

confidence: 99%

Guideline for the diagnosis and treatment of scabies in Japan (third edition)

2017

The Journal of Dermatology

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In the current work, we present our new guideline for the diagnosis and treatment of scabies which we, the Executive Committee convened by the Japanese Dermatological Association, developed to ensure proper diagnosis and treatment of scabies in Japan. Approval of phenothrin topical use under the National Health Insurance in August 2014 led to this action. Permethrin, a topical anti-scabietic medication belonging to the same pyrethroid group as phenothrin, is already in use worldwide. In this guideline, we introduce criteria for a proper diagnosis of scabies, treatment algorithm for common and crusted (hyperkeratotic) scabies, and prevention. The major change from our second edition is the treatment algorithm. As phenothrin is now available, the first-line therapy for common scabies is either topical phenothrin lotion or oral ivermectin. The second-line option for topical treatment is sulfur-containing ointments, crotamiton cream or benzyl benzoate lotion. γ-Benzene hexachloride ointment is no longer provided for clinical use. In an immunosuppressed patient, the treatment option is still the same, but with close follow up. If the symptoms persist, diagnosis and treatment must be reassessed. For hyperkeratotic scabies and nail scabies, removal of thick crust, cutting of nails and occlusive dressing are additionally required. The safety and effectiveness of combined treatment with topical and oral medications are not yet confirmed. Further assessment is needed. In addition to appropriate treatment, it is essential to educate patients and health-care workers and to conduct epidemiological studies to prevent further spread of the disease through effectively utilizing available resources including manpower, finance, logistics and time.

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“…Anlass waren letal endende Intoxikationen durch Spüllösungen für zentrale Katheter und Infuisonsleitungen, die Benzylalkohol als Bakteriostatikum enthielten. In Vergleichsstudien mit anderen Antiskabiosa hat sich Crotamiton als etwas weniger wirksam erwiesen (Tabelle 5) [2,28]. In der Monographie über Benzylbenzoat zur topischen Anwendung [6] [4].…”

Section: Stillzeitunclassified

Die Skabiestherapie unter besonderer Berücksichtigung des frühen Kindesalters, der Schwangerschaft und Stillzeit

Fölster‐Holst¹,

Rufli²,

Christophers³

2000

Der Hautarzt

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Infestation of human skin with scabies mites remains an persistent problem in daily dermatological practice. There are several therapeutic regiments against scabies which have been proven effective and without major side effects. Because of known neurotoxicity of lindane as well as intoxication/problems following systemic absorption of benzyl alcohol (the metabolite of benzyl benzoate), these two compounds have to be considered with caution in early childhood scabies as well as during pregnancy and nursing. The pharmacology and spectrum of clinical side effects of the approved anti-scabies preparations (lindane, benzyl benzoate, crotamiton) as well as permethrin (not available in Germany) are reviewed.

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Permethrin Versus Crotamiton and Lindane in the Treatment of Scabies

Cited by 35 publications

References 11 publications

Topical ivermectin versus crotamiton cream 10% for the treatment of scabies

Topical ivermectin versus crotamiton cream 10% for the treatment of scabies

Guideline for the diagnosis and treatment of scabies in Japan (third edition)

Die Skabiestherapie unter besonderer Berücksichtigung des frühen Kindesalters, der Schwangerschaft und Stillzeit

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