Permeation enhancers loaded bilosomes for improved intestinal absorption and cytotoxic activity of doxorubicin

Sultan, Amal A.; Saad, Gamal R.; Maghraby, Gamal M. El

doi:10.1016/j.ijpharm.2022.122427

Cited by 18 publications

(12 citation statements)

References 74 publications

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“…In addition to high patient compliance. Previous works revealed that bilosomes reflect higher deformability with increased intestinal stability and absorption 11,20 .…”

Section: Figure 2 Illustration Of Bilosomes Strength Against Intestin...mentioning

confidence: 99%

“…Based on these properties, bilosomes were exploited in delivering vaccines, drug polysaccharides, antigens, anticancer, and other macro-molecules 9,11,20,22 . Additionally, bilosomes were successively used to encapsulate risedronate with an increased bioavailability proofing the potential of bilosomes to deliver hydrophilic molecules 23 .…”

Section: Figure 2 Illustration Of Bilosomes Strength Against Intestin...mentioning

confidence: 99%

“…This method alleviates the use of organic solvents avoiding, therefore, its harmful effect on vaccines (WO 2018/011553 A2) 34 . Recently, bilosomes were prepared from their pro-concentrates with promising results 11 .…”

Section: Preparation Of Bilosomesmentioning

confidence: 99%

“…In the bilosomal structure, the bile salts are inserted within the lipid layers forming a unique closed shape. Compared to niosomes and liposomes, bilosomes have been reported to improve the oral bioavailability of many drugs such as acyclovir [9], carvedilol 10 , and doxorubicin 11 . When compared to niosomes, the composition of the vesicular wall is the key difference between the two systems (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

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Bilosomes As Oral Drug Delivery Carrier

Elebyary,

Sultan,

Abu-Risha

et al. 2024

Journal of Advanced Medical and Pharmaceutical Research

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Bilosomes are novel vesicular colloidal carriers that contain bile salts as one of the main components. Recently, bilosomes have gained significant attention as a drug delivery system due to the reported flexibility and stability, relative to other traditional vesicular carriers. As bile salts are natural endogenous surfactants, their presence in bilosomes imparts important characteristics to the vesicles such as biodegradability, compatibility, and minimal toxicity. Bilosomes were investigated for drug delivery through different routes of administration (such as transdermal, ocular, nose to brain) with improved therapeutic efficacy of the entrapped drug. This mini-review attempted to present a brief overview of the application of bilosomes in the oral delivery of drugs. When administered orally, the presence of bile salts in the main structure of bilosomes offers benefits over other vesicular systems. Bile salts provide protection to the vesicles against the effect of endogenous bile salts with improved therapeutic performance of the entrapped active pharmaceutical ingredient(s).

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“…In addition to high patient compliance. Previous works revealed that bilosomes reflect higher deformability with increased intestinal stability and absorption 11,20 .…”

Section: Figure 2 Illustration Of Bilosomes Strength Against Intestin...mentioning

confidence: 99%

Section: Figure 2 Illustration Of Bilosomes Strength Against Intestin...mentioning

confidence: 99%

Section: Preparation Of Bilosomesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Bilosomes As Oral Drug Delivery Carrier

Elebyary,

Sultan,

Abu-Risha

et al. 2024

Journal of Advanced Medical and Pharmaceutical Research

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“…Several formulation approaches have been investigated to improve the oral delivery of micronutrients. Prevention of stomach acid attack and enzymatic degradation through enteric coating [ 18 ] and increasing intestinal absorption via permeation enhancers [ 19 ] and nanocarrier systems [ 20 ] are potential strategies to increase the oral bioavailability of labile, poorly permeable molecules. Other methods, such as enzyme protease inhibitors (for peptides) and the use of mucoadhesive polymers, are also of interest.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Selenomethionine Entrapped in Nanoparticles for Oral Supplementation Using In Vitro, Ex Vivo and In Vivo Models

et al. 2023

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Selenium methionine (SeMet) is an essential micronutrient required for normal body function and is associated with additional health benefits. However, oral administration of SeMet can be challenging due to its purported narrow therapeutic index, low oral bioavailability, and high susceptibility to oxidation. To address these issues, SeMet was entrapped in zein-coated nanoparticles made from chitosan using an ionic gelation formulation. The high stability of both the SeMet and selenomethionine nanoparticles (SeMet-NPs) was established using cultured human intestinal and liver epithelial cells, rat liver homogenates, and rat intestinal homogenates and lumen washes. Minimal cytotoxicity to Caco-2 and HepG2 cells was observed for SeMet and SeMet-NPs. Antioxidant properties of SeMet were revealed using a Reactive Oxygen Species (ROS) assay, based on the observation of a concentration-dependent reduction in the build-up of peroxides, hydroxides and hydroxyl radicals in Caco-2 cells exposed to SeMet (6.25–100 μM). The basal apparent permeability coefficient (Papp) of SeMet across isolated rat jejunal mucosae mounted in Ussing chambers was low, but the Papp was increased when presented in NP. SeMet had minimal effects on the electrogenic ion secretion of rat jejunal and colonic mucosae in Ussing chambers. Intra-jejunal injections of SeMet-NPs to rats yielded increased plasma levels of SeMet after 3 h for the SeMet-NPs compared to free SeMet. Overall, there is potential to further develop SeMet-NPs for oral supplementation due to the increased intestinal permeability, versus free SeMet, and the low potential for toxicity.

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