Permeability versus Design in TPMS Scaffolds

Castro, A. P. G.; Pires, Tiago; Santos, Jorge; Gouveia, Bárbara; Fernandes, Paulo R.

doi:10.3390/ma12081313

Cited by 77 publications

(42 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Investigating 70% porous Schwarz and Gyroid produced using a photocurable polymer resin, they showed a dependency of permeability with the flow rate applied, which decreased inversely, and may explain the different values obtained in the present work. 17 Zhang et al also reported similar permeability values for graded porosities based on diamond geometries. 49 TPMS have gained scientific attention thanks to their outstanding mechanical properties despite their porous structure.…”

Section: Discussionmentioning

confidence: 71%

“…14 Some researchers have also applied TPMS designs using polymers, mainly based on acrylates, polyamides or styrenes through stereolitography (SLA), to investigate the mass transport or mechanical properties of the structures. [15][16][17][18] While the above polymer-or metallic-based TPMS structures might show biocompatibility, few studies have exploited the use of resorbable polymers which can serve as temporary constructs and further integrate into the bone remodelling process. In the present work, polylactic acid (PLA) was investigated as substrate material to manufacture TPMS scaffolds through fused deposition modelling (FDM).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Porous polylactic acid scaffolds for bone regeneration: A study of additively manufactured triply periodic minimal surfaces and their osteogenic potential

et al. 2020

View full text Add to dashboard Cite

Three different triply periodic minimal surfaces (TPMS) with three levels of porosity within those of cancellous bone were investigated as potential bone scaffolds. TPMS have emerged as potential designs to resemble the complex mechanical and mass transport properties of bone. Diamond, Schwarz, and Gyroid structures were 3D printed in polylactic acid, a resorbable medical grade material. The 3D printed structures were investigated for printing feasibility, and assessed by morphometric studies. Mechanical properties and permeability investigations resulted in similar values to cancellous bone. The morphometric analyses showed three different patterns of pore distribution: mono-, bi-, and multimodal pores. Subsequently, biological activity investigated with pre-osteoblastic cell lines showed no signs of cytotoxicity, and the scaffolds supported cell proliferation up to 3 weeks. Cell differentiation investigated by alkaline phosphatase showed an improvement for higher porosities and multimodal pore distributions, suggesting a higher dependency on pore distribution and size than the level of interconnectivity.

show abstract

Section: Discussionmentioning

confidence: 71%

Section: Introductionmentioning

confidence: 99%

Porous polylactic acid scaffolds for bone regeneration: A study of additively manufactured triply periodic minimal surfaces and their osteogenic potential

et al. 2020

View full text Add to dashboard Cite

show abstract

“…It could be seen in the results that the D surface had the highest specific surface (Guo et al, 2019). At the same time, many pieces of research indicated that the G surface had the highest permeability, which means adequate oxygen and nutrition delivery (Montazerian et al, 2017(Montazerian et al, , 2019Yang et al, 2018;Castro et al, 2019a;Ali et al, 2020). Therefore, the D and G surface might have the best bone growth, which needs to be verified by future biological experiments.…”

Section: Tpmsmentioning

confidence: 95%

Porous Scaffold Design for Additive Manufacturing in Orthopedics: A Review

Chen

Han

Wang

et al. 2020

Front. Bioeng. Biotechnol.

143

View full text Add to dashboard Cite

With the increasing application of orthopedic scaffolds, a dramatically increasing number of requirements for scaffolds are precise. The porous structure has been a fundamental design in the bone tissue engineering or orthopedic clinics because of its low Young's modulus, high compressive strength, and abundant cell accommodation space. The porous structure manufactured by additive manufacturing (AM) technology has controllable pore size, pore shape, and porosity. The single unit can be designed and arrayed with AM, which brings controllable pore characteristics and mechanical properties. This paper presents the current status of porous designs in AM technology. The porous structures are stated from the cellular structure and the whole structure. In the aspect of the cellular structure, non-parametric design and parametric design are discussed here according to whether the algorithm generates the structure or not. The non-parametric design comprises the diamond, the body-centered cubic, and the polyhedral structure, etc. The Voronoi, the Triply Periodic Minimal Surface, and other parametric designs are mainly discussed in parametric design. In the discussion of cellular structures, we emphasize the design, and the resulting biomechanical and biological effects caused by designs. In the aspect of the whole structure, the recent experimental researches are reviewed on uniform design, layered gradient design, and layered gradient design based on topological optimization, etc. These parts are summarized because of the development of technology and the demand for mechanics or bone growth. Finally, the challenges faced by the porous designs and prospects of porous structure in orthopedics are proposed in this paper.

show abstract

“…We consider tissue growth simulations on more complex surfaces such as triply periodic minimal surface (TPMS) which has interconnected pores and high porosity to ensure cell penetration, vascular ingrowth, nutrient diffusion, and waste product elimination [29]. TPMSs are widely used for the scaffold model structure, especially in tissue engineering applications.…”

Section: Simulation Of Tissue Growth On Scaffold In 3dmentioning

confidence: 99%

“…TPMSs are widely used for the scaffold model structure, especially in tissue engineering applications. Castro et al [29] investigated the effect of the porous structure of TPMS scaffolds on the macroscopic permeability behavior using numerical and experimental methods. The scaffold regions for the P, D, and G surfaces are defined by…”

Section: Simulation Of Tissue Growth On Scaffold In 3dmentioning

confidence: 99%

Mathematical Model and Numerical Simulation for Tissue Growth on Bioscaffolds

et al. 2019

View full text Add to dashboard Cite

Tissue growth on bioscaffolds can be controlled using substrate geometry such as substrate curvature. In this study, we present a mathematical model and numerical simulation method for tissue growth on a bioscaffold to investigate the effect of local curvature on tissue growth. The mathematical model is based on the Allen–Cahn (AC) equation, which has been extensively used to model many problems involving motion by mean curvature. By solving the AC equation using the explicit Euler method, the proposed method is simple and fast. Numerical simulations on various geometries are presented to demonstrate the applicability of the proposed framework on tissue growth on a bioscaffold.

show abstract

Permeability versus Design in TPMS Scaffolds

Cited by 77 publications

References 19 publications

Porous polylactic acid scaffolds for bone regeneration: A study of additively manufactured triply periodic minimal surfaces and their osteogenic potential

Porous polylactic acid scaffolds for bone regeneration: A study of additively manufactured triply periodic minimal surfaces and their osteogenic potential

Porous Scaffold Design for Additive Manufacturing in Orthopedics: A Review

Mathematical Model and Numerical Simulation for Tissue Growth on Bioscaffolds

Contact Info

Product

Resources

About