Permeability of the Blood-Brain Barrier in the Rat after Local Proton Irradiation

Lundqvist, Hans; Rosander, Kerstin; Lomanov, M.F.; Lukjashin, V.; Shimchuk, G. G.; Zolotov, V A; Minakova, E I

doi:10.3109/02841868209134015

Cited by 15 publications

(4 citation statements)

References 5 publications

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“…In the first weeks after irradiation, there is a modest but definite breakdown of the BBB; this effect is transitory and is followed by a period of functional recovery and a latent period of normal BBB function. 18,19 However, the endothelial cells have significant irreparable chromosomal damage and reproductive death, leading to a relatively declining number of surviving cells. This latent period, the period of apparent recovery, ends when the number of surviving cells drops below the level required to maintain function, leading to an eventual increase in vascular permeability.…”

Section: Radiation-induced Permeability Changesmentioning

confidence: 99%

Permeability Estimates in Histopathology-Proved Treatment-Induced Necrosis Using Perfusion CT: Can These Add to Other Perfusion Parameters in Differentiating from Recurrent/Progressive Tumors?

Jain¹,

Narang²,

Schultz³

et al. 2011

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE: Differentiating treatment effects from RPT is a common yet challenging task in a busy neuro-oncologic pratice. PS probably represents a different aspect of angiogenesis and vasculature and can provide additional physiologic information about recurrent/progressive enhancing lesions. The purpose of the study was to use PS measured by using PCT to differentiate TIN from RPT in patients with previously irradiated brain tumor who presented with a recurrent/progressive enhancing lesion.

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Section: Radiation-induced Permeability Changesmentioning

confidence: 99%

Permeability Estimates in Histopathology-Proved Treatment-Induced Necrosis Using Perfusion CT: Can These Add to Other Perfusion Parameters in Differentiating from Recurrent/Progressive Tumors?

Jain¹,

Narang²,

Schultz³

et al. 2011

AJNR Am J Neuroradiol

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“…As a result, the use of this procedure is restricted to specialized centers, has not found widespread acceptance, and does not lend itself to use in general clinical practice. Similarly, the effects of radiation on BBB permeability have long been recognized [136] and are thought to impact BBB integrity through the killing of endothelial cells and resulting neuro-inflammatory reactions [137]. However, many details, including the time course and magnitude of increased opening, remain to be established [138].…”

Section: Intra-arterial Perillyl Alcoholmentioning

confidence: 99%

The Monoterpenoid Perillyl Alcohol: Anticancer Agent and Medium to Overcome Biological Barriers

et al. 2021

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Perillyl alcohol (POH) is a naturally occurring monoterpenoid related to limonene that is present in the essential oils of various plants. It has diverse applications and can be found in household items, including foods, cosmetics, and cleaning supplies. Over the past three decades, it has also been investigated for its potential anticancer activity. Clinical trials with an oral POH formulation administered to cancer patients failed to realize therapeutic expectations, although an intra-nasal POH formulation yielded encouraging results in malignant glioma patients. Based on its amphipathic nature, POH revealed the ability to overcome biological barriers, primarily the blood–brain barrier (BBB), but also the cytoplasmic membrane and the skin, which appear to be characteristics that critically contribute to POH’s value for drug development and delivery. In this review, we present the physicochemical properties of POH that underlie its ability to overcome the obstacles placed by different types of biological barriers and consequently shape its multifaceted promise for cancer therapy and applications in drug development. We summarized and appraised the great variety of preclinical and clinical studies that investigated the use of POH for intranasal delivery and nose-to-brain drug transport, its intra-arterial delivery for BBB opening, and its permeation-enhancing function in hybrid molecules, where POH is combined with or conjugated to other therapeutic pharmacologic agents, yielding new chemical entities with novel mechanisms of action and applications.

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“…For example, recent studies have established proton irradiation of mouse brain subvolumes [42,59] to investigate the underlying causes of radiation-induced brain lesions appearing after proton therapy [10,18]. Overall, central nervous system (CNS) toxicity studies in rodent models are of increasing interest and performed from both a behavioral [213][214][215] and histological perspective [59,216,217]. Using clinically relevant settings is crucial in developing protocols that reduce normal tissue complications.…”

Section: Rodentsmentioning

confidence: 99%

Models for Translational Proton Radiobiology—From Bench to Bedside and Back

Suckert

Nexhipi

Dietrich

et al. 2021

Cancers

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The number of proton therapy centers worldwide are increasing steadily, with more than two million cancer patients treated so far. Despite this development, pending questions on proton radiobiology still call for basic and translational preclinical research. Open issues are the on-going discussion on an energy-dependent varying proton RBE (relative biological effectiveness), a better characterization of normal tissue side effects and combination treatments with drugs originally developed for photon therapy. At the same time, novel possibilities arise, such as radioimmunotherapy, and new proton therapy schemata, such as FLASH irradiation and proton mini-beams. The study of those aspects demands for radiobiological models at different stages along the translational chain, allowing the investigation of mechanisms from the molecular level to whole organisms. Focusing on the challenges and specifics of proton research, this review summarizes the different available models, ranging from in vitro systems to animal studies of increasing complexity as well as complementing in silico approaches.

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Permeability of the Blood-Brain Barrier in the Rat after Local Proton Irradiation

Cited by 15 publications

References 5 publications

Permeability Estimates in Histopathology-Proved Treatment-Induced Necrosis Using Perfusion CT: Can These Add to Other Perfusion Parameters in Differentiating from Recurrent/Progressive Tumors?

Permeability Estimates in Histopathology-Proved Treatment-Induced Necrosis Using Perfusion CT: Can These Add to Other Perfusion Parameters in Differentiating from Recurrent/Progressive Tumors?

The Monoterpenoid Perillyl Alcohol: Anticancer Agent and Medium to Overcome Biological Barriers

Models for Translational Proton Radiobiology—From Bench to Bedside and Back

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