Permeability and fluid flow-induced wall shear stress in bone scaffolds with TPMS and lattice architectures: A CFD analysis

Davar, Ali; Özalp, Mehmet; Blanquer, Sébastien; Onel, Selis

doi:10.1016/j.euromechflu.2019.09.015

Cited by 118 publications

(44 citation statements)

References 49 publications

(65 reference statements)

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“…2), the parameters of which are described in Table. The table presents the physical parameters of the simulated scaffolds, according to which their average pore size is in the range from 3 to 7 mm, while their masses are comparable, the average mass is 8.213 ± 0.13 g. Obviously, the geometric shape and pore sizes affect the porosity of the entire scaffold structure, and according to the calculations, the average porosity value is 0.705 ± 0.06. The measurement of the values of the volume fraction of voids for all types of scaffold structures varied from 64 to 76%, which is consistent with the data presented in experimental works [39][40][41][42]. Figure 3 shows the results of numerical simulation of the rate of diffusion flow of nutrients based on glucose in the porous structure of different types of scaffolds.…”

Section: Results Of Internal Flow Modelingsupporting

confidence: 87%

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A Numerical Study of Fluid Flow in the Porous Structure of Biological Scaffolds

Daulbayev

Mansurov

Sultanov

et al. 2020

Eurasian Chem. Tech. J.

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Tissue engineering (TE) is one of the promising areas that aims to address the global problem of organ and tissue shortages. The successful development of TE, particularly in bone tissue engineering, consists of the use of modern methods that allow the creation of scaffolds, the physicochemical, mechanical, and structural parameters of which will allow achieving the desired clinical results. The vast possibilities of the rapidly developing technology of three-dimensional (3D) printing, which allows the creation of individual scaffolds with high precision, has led to various developments in bone tissue TE. In this work, for the successful use of three-dimensional printing in TE to ensure the diffusion of nutrients during cell cultivation throughout the entire structure of the scaffold, a model of a rotating scaffold is proposed, and the movement of the diffusion flow of nutrient fluid is calculated based on Darcy’s law, which regulates the flow of fluids through porous media. The conducted studies of the rate of diffusion flow of nutrients based on glucose in the porous structure of scaffolds with a 10% content of calcium hydroxyapatite demonstrated the promise of using a model of a rotating composite scaffold in TE of bone tissue. The results show that at a scaffold rotation speed of 12 rpm, the diffusion flow rate of nutrients in the composite scaffolds porous structure is practically not affected by their geometric shape.

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Section: Results Of Internal Flow Modelingsupporting

confidence: 87%

“…3b) indicates that the pores do not significantly affect the rate of nutrient spread. Such behavior at similar parameters is confirmed in experimental works [42,[46][47][48] and possibly indicates the selection of the optimal scaffold rotation rate. At rotation rates of 24 rpm (Fig.…”

Section: Results Of Internal Flow Modelingsupporting

confidence: 66%

A Numerical Study of Fluid Flow in the Porous Structure of Biological Scaffolds

Daulbayev

Mansurov

Sultanov

et al. 2020

Eurasian Chem. Tech. J.

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“…It could be seen in the results that the D surface had the highest specific surface (Guo et al, 2019). At the same time, many pieces of research indicated that the G surface had the highest permeability, which means adequate oxygen and nutrition delivery (Montazerian et al, 2017(Montazerian et al, , 2019Yang et al, 2018;Castro et al, 2019a;Ali et al, 2020). Therefore, the D and G surface might have the best bone growth, which needs to be verified by future biological experiments.…”

Section: Tpmsmentioning

confidence: 95%

Porous Scaffold Design for Additive Manufacturing in Orthopedics: A Review

Chen

Han

Wang

et al. 2020

Front. Bioeng. Biotechnol.

126

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With the increasing application of orthopedic scaffolds, a dramatically increasing number of requirements for scaffolds are precise. The porous structure has been a fundamental design in the bone tissue engineering or orthopedic clinics because of its low Young's modulus, high compressive strength, and abundant cell accommodation space. The porous structure manufactured by additive manufacturing (AM) technology has controllable pore size, pore shape, and porosity. The single unit can be designed and arrayed with AM, which brings controllable pore characteristics and mechanical properties. This paper presents the current status of porous designs in AM technology. The porous structures are stated from the cellular structure and the whole structure. In the aspect of the cellular structure, non-parametric design and parametric design are discussed here according to whether the algorithm generates the structure or not. The non-parametric design comprises the diamond, the body-centered cubic, and the polyhedral structure, etc. The Voronoi, the Triply Periodic Minimal Surface, and other parametric designs are mainly discussed in parametric design. In the discussion of cellular structures, we emphasize the design, and the resulting biomechanical and biological effects caused by designs. In the aspect of the whole structure, the recent experimental researches are reviewed on uniform design, layered gradient design, and layered gradient design based on topological optimization, etc. These parts are summarized because of the development of technology and the demand for mechanics or bone growth. Finally, the challenges faced by the porous designs and prospects of porous structure in orthopedics are proposed in this paper.

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“…They were regarded as effective tools for designing scaffolds with gradual and regular porous structures [11,12]. Recently, Ali et al [13] designed eight different bone scaffolds based on TPMS and proved these architectures have a significant impact on permeability. Li et al [14] successfully prepared the Ti6Al4V scaffold with TPMS of p-cell.…”

Section: Introduction mentioning

confidence: 99%

High performance hydroxyapatite ceramics and a triply periodic minimum surface structure fabricated by digital light processing 3D printing

et al. 2021

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High performance hydroxyapatite (HA) ceramics with excellent densification and mechanical properties were successfully fabricated by digital light processing (DLP) three-dimensional (3D) printing technology. It was found that the sintering atmosphere of wet CO2 can dramatically improve the densification process and thus lead to better mechanical properties. HA ceramics with a relative density of 97.12% and a three-point bending strength of 92.4 MPa can be achieved at a sintering temperature of 1300 , which makes a solid foundation for application ℃ in bone engineering. Furthermore, a relatively high compressive strength of 4.09 MPa can be also achieved for a DLP-printed p-cell triply periodic minimum surface (TPMS) structure with a porosity of 74%, which meets the requirement of cancellous bone substitutes. A further cell proliferation test demonstrated that the sintering atmosphere of wet CO2 led to improve cell vitality after 7 days of cell culture Moreover, with the possible benefit from the bio-inspired structure, the 3D-printed TPMS structure significantly improved the cell vitality, which is crucial for early osteogenesis and osteointegration.

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Permeability and fluid flow-induced wall shear stress in bone scaffolds with TPMS and lattice architectures: A CFD analysis

Cited by 118 publications

References 49 publications

A Numerical Study of Fluid Flow in the Porous Structure of Biological Scaffolds

A Numerical Study of Fluid Flow in the Porous Structure of Biological Scaffolds

Porous Scaffold Design for Additive Manufacturing in Orthopedics: A Review

High performance hydroxyapatite ceramics and a triply periodic minimum surface structure fabricated by digital light processing 3D printing

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