“…1 With the growing demand for environmentfriendly synthesis protocols, there has been increased focus on 1,3-dipolar cycloaddition reactions in aqueous media. 2 Nitrile oxide, one of the most popular classes of 1,3-dipoles, affords isoxazoles, 2-isoxazolines, and 1,2,4-oxadiazoles upon 25 treatment with alkynes, alkenes, and nitriles, respectively. [1][2][3][4] While there are numerous reports on nitrile oxides, most of them are related to aryl-or alkyl-substituted nitrile oxides.…”