Permanent Sterility in the Male Rat After a Single Oral Dose of a Pipecolinomethylhydroxyindane

Abstract

Summary. A single oral dose of dl-6-(N-\g=a\-pipecolinomethyl)-5\x=req-\ hydroxy-indane maleate caused subnormal fertility in the male rat during the 3rd and 4th week after administration. Sterility ensued from the 5th week and persisted to the termination of the experiment 20 weeks after dosing. The antitesticular activity of DL-6-(N-a-pipecolinomethyl)-5-hydroxyindane maléate (PMHI) in the rat and other species has been described (Boris, Ng & Hurley, 1974;Boris, DeMartino & Cox, 1974). These studies also indicated that treatment with PMHI for 21 days caused sterility in male rats, and that the reversibility of the antifertility effect depended on the dose which had been given. The (Jackson, 1966). The apparent normal fertility of rats treated with PMHI during the 441

Effect of DL‐6‐(N‐α‐pipecolinomethyl)‐5‐hydroxy‐indane maleate (PMHI) on the reproductive system of a wild rat, Bandicota bengalensis

“…The results obtained in the present study, therefore, demonstrate that PMHI produces a reversible anti-spermatogenic action in the bandicoot rat and spermatogonia appear to be the most resistant cells to this compound at the dose level employed. The present results do not apparently agree with those of Boris et al (1974~) who reported that a single oral dose of PMHI (150 mgikg) induced irreversible degenerative changes in the testis of laboratory (Sprague-Dawley) rats. Surprisingly, Fang & Anderson (1976) failed to observe permanent testicular damage in the same strain of laboratory rats even following a toxic dose of PMHI (180 mg/kg body weight).…”

“…The antispermatogenic action of DL-6-(N-a-pipecolinomethyl)-5-hydroxy-indane maleate (PMHI) has been described in the rat and various other mammalian species (Boris et al 1974a,b,c;Fang & Anderson 1976). A single oral dose (150 mg/kg body weight) of PMHI causes permanent destruction of spermatogenic capability and irreversible sterility in laboratory (Sprague-Dawley) rats (Boris et al 1974~). By contrast, Fang & Anderson (1976) demonstrated that this compound produces a reversible anti-spermatogenic effect in the same strain of rats.…”

Effects of Pipecolinomethylhydroxyindane on Testicular and Adrenocortical Function in Rats

“…In the rat, PMHI caused a relatively greater reduction in testicular weight than other antigonadal agents such as nitrofurane, methallibure and diethylstilbestrol, and appears to act directly upon the testis leading to destruction of the spermatogenic epithelium [2]. Furthermore, a single oral dose of the indane derivative caused loss of spermatogenesis in rats without drastic effects upon the weights of the accessory sex organs [3]. This suggests that the testicular actions of PMHI are largely confined to the seminiferous tubules, without effect upon the interstitium and androgenesis.…”