Permanent prostate brachytherapy using high V150

Serrano, N.; Pham, Huong; Narayanan, Sampath; Badiozamani, K.

doi:10.1016/j.prro.2014.06.008

Cited by 1 publication

(1 citation statement)

References 31 publications

(28 reference statements)

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“…Furthermore, these images also contained titaniumencapsulated seeds, which locally influence the dose distribution of EBT in the PTV. A particularity of EBT and iodine seeds is the absorption property of low-energy X-rays, with dose gradients of up to 50% per millimeter in close proximity to the applicator, provoking an inhomogeneity in the dose distribution with parts of the PTV receiving substantially more than 100% of the prescribed dose [25,26]. A greater number of dwell positions could mitigate these hot spots, but the treatment of lesions that contain radiation-sensitive structures should be cautiously evaluated.…”

Section: Discussionmentioning

confidence: 99%

Feasibility of interstitial stepping-source electronic brachytherapy to locally inoperable tumors

Ruder

Inghelram

Schneider

et al. 2020

jcb

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Purpose Radiotherapy is the mainstay in the treatment of locally inoperable tumors. Interstitial electronic needle-based kilovoltage brachytherapy (EBT) could be an economic alternative to high-dose-rate (HDR) brachytherapy or permanent seed implantation (PSI). In this work, we evaluated if locally inoperable tumors treated with PSI at our institution may be suitable for EBT. Material and methods A total of 10 post-interventional computed tomography (CT) scans of patients, who received PSI and simulated stepping-source EBT applied with Intrabeam system and needle applicator were used. EBT treatment planning software with 3-dimensional image and projection of applicator were applied for designing trajectories and establishing dwell positions. Dwell position doses were summarized, and doses covering 90% of the target volume (D 90 ) achieved with stepping-source EBT were compared to those of PSI. Additionally, conformality of dose distributions and total irradiation time were assessed using conformation number (CN) or conformal index (COIN). Results In all patients, D 90 of EBT exceeded the prescribed dose or D 90 of PSI on average by 4.7% or 21.3% relative to the prescribed dose, respectively. Mean number of trajectories was 5.0 for EBT and 6.9 for PSI. Average CN/COIN for EBT was 0.69, with a mean irradiation time of 27.8 minutes for standardized dose of 13 Gy. Conclusions Stepping-source EBT allowed for a conformal treatment of inoperable interstitial tumors with similar D 90 . Fewer trajectories were required for EBT in majority of cases.

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Section: Discussionmentioning

confidence: 99%