Permanent Implantation as Brachytherapy Technique for Prostate Carcinoma-Review of Clinical Trials and Guidelines

Georgakopoulos, John; Zygogianni, Anna; Papadopoulos, Georgios; Παπανδρεου, Νικολαοσ; Kouvaris, John; Armonis, Vassilios; Kelekis, Nikolaos; Kouloulias, Vasileios

doi:10.2174/157488712802281268

Cited by 2 publications

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“…Copper I is generally used by radio-oncologists as brachytherapy to treat cancer at sites other than the thyroid, such prostate cancer and brain tumors [66,67]. When the radioactive sealed source of 125 I is used in therapy, it is encapsulated in titanium (Ti) seeds and implanted in the area of the tumor, where it remains.…”

Section: Copper-64mentioning

confidence: 99%

Inorganics in Nuclear Medicine

Ahmad¹

2016

Int. J. Nucl. Medi. Res.

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More than 130 radionuclides are being used worldwide for therapeutic, diagnostic, and preventative purposes in the medical field. Using radionuclides, different organs can be imaged, and malfunction revealed. The most commonly used radionuclide in diagnosis by SPECT is technetium-99m (99m Tc), with some 40 million procedures yearly, almost 80% of all nuclear medicine procedures in the world. The Positron Emission Tomography (PET) is sophisticated and more precise technique using isotopes, like 18 F produced in a cyclotron. The synthesis and use of organic molecules and their labeling with radionuclides are currently dominating in new radiopharmaceutical development. On the other hand inorganics (60 Co, 131 I and 192 Ir) are still playing unique role in nuclear medicine. In this article more commonly used radionuclides and their inorganic forms in nuclear medicine are described.

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Section: Copper-64mentioning

confidence: 99%

Inorganics in Nuclear Medicine

Ahmad¹

2016

Int. J. Nucl. Medi. Res.

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The Effect of Quercetin in the Yishen Tongluo Jiedu Recipe on the Development of Prostate Cancer through the Akt1-related CXCL12/ CXCR4 Pathway

Zhou

et al. 2024

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Background: It remains a challenge to effectively treat prostate cancer (PCa) that affects global men's health. It is essential to find a natural alternative drug and explore its antitumor mechanism due to the serious toxic side effects of chemotherapy. Methods: The targets and signaling pathways were analyzed by network pharmacology and verified by molecular docking and LC-MS. The proliferation, apoptosis, invasion, and migration of DU145 cells were detected by the CCK-8 method, flow cytometry, and Transwell, respectively. The Bcl-2, caspase-3, CXCL12, and CXCR4 expressions and Akt1 phosphorylation were determined by Western blot. Akt1 overexpression was applied to identify the involvement of the Akt1-related CXCL12/CXCR4 pathway in regulating PCa. Nude mouse tumorigenesis was performed to analyze the effect of quercetin on PCa in vivo. Results: Network pharmacology results displayed that quercetin was the main active component of the Yishen Tongluo Jiedu recipe and Akt1 was the therapy target of PCa. LC-MS analysis showed that quercetin existed in the Yishen Tongluo Jiedu recipe, and molecular docking proved that quercetin bound to Akt1. Quercetin inhibited the proliferation of DU145 cells by upregulating caspase-3 and downregulating Bcl-2 expression, promoting apoptosis and reducing invasion and migration abilities. In vivo, quercetin downregulated CXCL12 and CXCR4 expressions and inhibited PCa development by the Akt1-related CXCL12/CXCR4 pathway. Conclusion: As the active component of the Yishen Tongluo Jiedu recipe, quercetin inhibited PCa development through the Akt1-related CXCL12/CXCR4 pathway. This study provided a new idea for PCa treatment and a theoretical basis for further research.

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Permanent Implantation as Brachytherapy Technique for Prostate Carcinoma-Review of Clinical Trials and Guidelines

Cited by 2 publications

References 0 publications

Inorganics in Nuclear Medicine

Inorganics in Nuclear Medicine

The Effect of Quercetin in the Yishen Tongluo Jiedu Recipe on the Development of Prostate Cancer through the Akt1-related CXCL12/ CXCR4 Pathway

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