Permanent central diabetes insipidus after traumatic brain injury. Case report and literature review

Astafyeva, Ludmila; Sidneva, Yuliya; Badmaeva, I N; Kalinin, Pavel; Latyshev, Ya A; Marshintsev, A. V.; Valiullina, Svetlana A.

doi:10.17116/neiro202286051112

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…A great example of this are the endocrine repercussions presented in cases of damage to the hypothalamus-pituitary axis, whether directly or in the architecture of the rods pituitary or in the gland specifically, or even be secondary to diffuse and communicating axonal damage of that axis. A case described was the one of Astafyeva et al (2022) in which a peculiarity in the prognosis, the development of DI by a Russian teenager, after TBI in an automobile accident that culminated in a depression of the cranial vault and reaching the sell a turcica. As an initial manifestation of DI, a condition of polyuria 3 days after the injury and the return of full consciousness of the patient only 21 days after the injury, which even with multidisciplinary and continuous treatment with reconstruction of the affected cranial region, the endocrine disorder developed made it permanent in this case, further demonstrating the diverse characterization of post-traumatic sequelae.…”

Section: Discussionmentioning

confidence: 99%

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Recovery Profile of Patients Suffered with Traumatic Brains Injuries (TBI): Analysis of Case Reports

Brito,

Botelho,

Santos

2023

JAMMR

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Aims: Identify the different recovery profiles of patients with traumatic brain injury (TBI). Methodology: This study constituted a review of the literature based on the analysis of case reports published in past five years, about the profile of recovery of TBI victims on PubMed database. Manuscript in English and Portuguese language were considered. About of criteria of elegibility were priorized articles containing information about: Patient’s ages, genders, and complaints, TBI classification treatment, recovery, follow-up, and sequelae of the victims. Post-mortem studies and focused on surgical or drug treatment of the affected patient were exclused. Results: Based on the established criteria, 08 studies were selected that contained information about the recovery of patients affected by TBI and that contemplated the established selection criteria. Discussion: Among the results obtained, regarding the recovery profile of patients who are victims of traumatic brain injury, we list the recognition of the similarity of the pathogenic mechanisms involved in TBI, the emergence of various posterior dysfunctions, interdependence of severity, affected area and immediate intervention chosen. As well as, a variation of conducts was presented in each case, added to the significant evidence of the involvement of external factors among the prognosis on a case-by-case basis, such as: the lack of hospital structure, time until the beginning of the intervention and the presence of irreversible sequelae that they can be from a single or multiple body systems depending on the case. Conclusion: The recovery profile of TBI patients can vary depending on the severity and extent of brain damage. These patients usually undergo a multidisciplinary rehabilitation process aimed at promoting functional recovery and improving quality of life. In the early stages of recovery, it is common for patients to have physical, cognitive, and emotional impairments. In addition, neuropsychological rehabilitation is essential to treat cognitive deficits, such as memory, attention, concentration and reasoning problems.

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Section: Discussionmentioning

confidence: 99%

“…The patient recovered well but developed advancing dysarthria and right-sided hemiparesis. Permanent diabetes insipidus after traumatic brain injury: case report and literature review [12] A 16-year-old male patient presented with diabetes insipidus.…”

Section: Discussionmentioning

confidence: 99%

Recovery Profile of Patients Suffered with Traumatic Brains Injuries (TBI): Analysis of Case Reports

Brito,

Botelho,

Santos

2023

JAMMR

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“…With high-velocity blunt force, the bones of the skull base can break, leading to substantial complications, such as cerebrospinal fluid (CSF) leakage and cranial nerve palsies [9,10]. While the epidemiology of skull base fractures is not well characterized, it is reported that between 4 and 20% of children with head trauma will suffer from such an injury [11].…”

Section: Introductionmentioning

confidence: 99%

Clinical Features and Management of Skull Base Fractures in the Pediatric Population: A Systematic Review

Jung,

Xavier,

Reisert

et al. 2024

Children

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Pediatric basilar skull fractures (BSFs) are a rare type of traumatic head injury that can cause debilitating complications without prompt treatment. Here, we sought to review the literature and characterize the clinical features, management, and outcomes of pediatric BSFs. We identified 21 relevant studies, excluding reviews, meta-analyses, and non-English articles. The incidence of pediatric BSFs ranged from 0.0001% to 7.3%, with falls from multi-level heights and traffic accidents being the primary causes (9/21). The median presentation age ranged from 3.2 to 12.8 years, and the mean age of patients across all studies was 8.68 years. Up to 55% of pediatric BSFs presented with intracranial hematoma/hemorrhage, along with pneumocephalus and edema. Cranial nerve palsies were a common complication (9/21), with the facial nerve injured most frequently (7/21). While delayed cranial nerve palsy was reported in a few studies (4/21), most resolved within three months post-admission. Other complications included CSF leaks (10/21) and meningitis (4/21). Management included IV fluids, antiemetics, and surgery (8/21) to treat the fracture directly, address a CSF leak, or achieve cranial nerve compression. Despite their rarity, pediatric skull base fractures are associated with clinical complications, including CSF leaks and cranial nerve palsies. Given that some of these complications may be delayed, patient education is critical.

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An Approach to Traumatic Brain Injury-Related Hypopituitarism: Overcoming the Pediatric Challenges

et al. 2023

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Traumatic brain injury (TBI)-related hypopituitarism is a rare polymorphic complication of brain injury, with very little data, particularly concerning children and teenagers. This is a comprehensive review of the literature regarding this pathology, starting from a new pediatric case. The research was conducted on PubMed and included publications from the last 22 years. We identified nine original studies on the pediatric population (two case reports and seven studies; only four of these seven were prospective studies). TBI-related hypopituitarism is associated with isolated hormonal deficits ranging from 22.5% to 86% and multiple hormonal deficiencies from 5.9% to 50% in the studied pediatric population. Growth hormone (GH) deficiency is most often found, including the form with late occurrence after TBI; it was described as persistent in half of the studies. Thyroid-stimulating hormone (TSH) deficiency is identified as a distant complication following TBI; in all three studies, we identified this complication was found to be permanent. Adrenocorticotropic hormone (ACTH) deficiency did not relate to a certain type of brain trauma, and it was transient in reported cases. Hyperprolactinemia was the most frequent hormonal finding, also occurring late after injury. Central diabetes insipidus was encountered early post-TBI, typically with a transient pattern and did not relate to a particular type of injury. TBI-related hypopituitarism, although rare in children, should be taken into consideration even after a long time since the trauma. A multidisciplinary approach is needed if the patient is to safely overcome any acute condition.

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Permanent central diabetes insipidus after traumatic brain injury. Case report and literature review

Cited by 3 publications

References 19 publications

Recovery Profile of Patients Suffered with Traumatic Brains Injuries (TBI): Analysis of Case Reports

Recovery Profile of Patients Suffered with Traumatic Brains Injuries (TBI): Analysis of Case Reports

Clinical Features and Management of Skull Base Fractures in the Pediatric Population: A Systematic Review

An Approach to Traumatic Brain Injury-Related Hypopituitarism: Overcoming the Pediatric Challenges

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