Permanent alopecia after cranial irradiation: Dose–response relationship

Lawenda, Brian D.; Gagne, Havaleh; Gierga, David P.; Niemierko, Andrzej; Wong, Winnie; Tarbell, Nancy J.; Chen, George T.Y.; Hochberg, Fred H.; Loeffler, Jay S.

doi:10.1016/j.ijrobp.2004.04.031

Cited by 117 publications

(98 citation statements)

References 26 publications

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“…But this effect was shown to be dose-dependent, and usually observed at very high doses. 25 The protective effect of BU-CY on cataract was found only in CML patients. Remarkably, TBI-CY AML patients reported only 12.4% of cataracts at 7 years.…”

Section: Health Status After Hct F Bernard Et Almentioning

confidence: 99%

Health status of childhood leukemia survivors who received hematopoietic cell transplantation after BU or TBI: an LEA study

Bernard

Auquier

Herrmann

et al. 2014

Bone Marrow Transplant

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The purpose of this multicenter study was to compare the long-term impact of a preparative regimen with either BUBU or TBI on health status and quality of life (QoL) in childhood acute leukemia survivors treated with hematopoietic SCT (HSCT). Two-hundred and forty patients were included. Sixty-six had received BU, while 174 had received TBI. Median follow-up from HSCT was 10.1 years. Multivariate analyses were performed to assess the occurrence of late effects according to treatment. QoL was assessed in 130 adults using SF-36 questionnaires. Patients developed fewer late complications after BU (2.35 vs 3.01, P ¼ 0.03) while the risk to present with at least one complication was equivalent in both groups (87.9% after BU and 93.1% after TBI, P ¼ 0.66). Detailed multivariate analyses revealed a lower risk of height growth failure (OR ¼ 0.2), cataract (OR ¼ 0.1) and iron overload (OR ¼ 0.2) after BU, and an increased risk of overweight (OR ¼ 3.9) and alopecia (OR ¼ 11.2). SF-36 mental and physical composite scores were similar in both treatment groups and proved significantly lower than French norms. Late effects induced by BU might differ from those experienced after TBI. Although less frequent, they are still of considerable importance and may affect patients' QoL.

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Section: Health Status After Hct F Bernard Et Almentioning

confidence: 99%

Health status of childhood leukemia survivors who received hematopoietic cell transplantation after BU or TBI: an LEA study

Bernard

Auquier

Herrmann

et al. 2014

Bone Marrow Transplant

View full text Add to dashboard Cite

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“…1 When basal cell carcinomas are located in previously irradiated areas or with radiotherapy sequels, the association between this therapy modality and the appearance of skin neoplasia is strengthened. 2,5 Ionizing radiation is a well-established etiological factor for generation of basal cell carcinoma and the development of these tumors is probably due to a complex interaction of factors. The simple development of a basal cell carcinoma in a skin area that was previously exposed to radiotherapy is not sufficient to establish a causal relationship between neoplasia and radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

Dermoscopy of multiple radiation-induced basal cell carcinomas in a patient treated previously for pinealoma

Siqueira

Trope

Cavalcante

et al. 2014

J Dermatol Case Rep

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Background: Malignancies secondary to radiation, such as radiation-induced skin cancer, are possible consequences of radiation therapy. The most frequent postradiation skin neoplasm is basal cell carcinoma. Main observations:We report a case of a 49-year-old woman who underwent multiple radiotherapy sessions for pinealoma and developed post-radiation alopecia. After 26 years the patient noticed the emergence of eighteen superficial scalp lesions in the previously irradiated areas. Dermoscopy showed predominance of ovoid nests and presence of arborizing vessels on pink background, consistent with basal cells carcinoma. The diagnosis was confirmed by histopathology. Conclusion:There is an absolute need to guide patients through the possible late adverse events of radiotherapy. Regular dermoscopy examinations should be performed, especially in areas previously exposed to radiation. (J Dermatol Case Rep.

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“…The decision to deliver 50 Gy in 25 fractions was influenced by the work published by Lawenda et al [6]. In their Fig.…”

Section: Discussionmentioning

confidence: 99%

Intensity-modulated radiation therapy for permanent alopecia of unwanted palatal hair

et al. 2012

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Options for unwanted intraoral hair removal associated with flap reconstruction may include trimming, electrolysis, mechanical epilation, and laser and light epilation. These methods provide temporary relief and often require repeated treatment, with laser and light epilation providing the most durable response. Therapeutic external beam radiation used in the treatment of cancer is known to cause temporary alopecia at low doses and permanent alopecia at higher doses. We report a case of a man who underwent oncologic resection for early stage retromolar trigone cancer. His surgical defect required reconstruction with a submental flap. Post-operatively, his flap grew a thick beard within his oral cavity that was extremely bothersome. Due to the location of the flap, trimming, electrolysis, laser, and light epilation were not recommended treatment options. He was referred to us for consideration of external beam radiation with the goal of permanent alopecia of his intraoral graft.Keywords Palatal hair . Radiation-induced alopecia . Hair removal . Oral cavity reconstruction Case reportA 71-year-old smoker presented with a pedicled mass on the left hard palate extending behind the maxillary gingiva, down the retromolar trigone to the posterior mandibular buccal sulcus, and onto the buccal surface. Biopsy confirmed a spindled squamous cell carcinoma. CT scan showed a 2.5×2.0 cm mass of the left posterior roof of the oral cavity. PET/CT scan confirmed uptake in the hard palate and left retromolar trigone with two hypermetabolic lymph nodes in level II. His past medical history included lung cancer treated with resection and adjuvant radiation 7 years prior, chronic obstructive pulmonary disease with oxygen dependence at night, and recurrent pneumonias. He had a 100+ pack-year smoking history and quit at the time of his diagnosis.Oncologic resection was performed, with pathology revealing two separate primaries. The first lesion was a 3.8-cm spindle cell squamous carcinoma of the hard palate with a depth of invasion of 2 mm, no bone involvement, no perineural invasion, and negative margins. The diameter of the pedicle of the mass was smaller than maximum diameter. The second lesion was a 1.5 cm moderately differentiated squamous cell carcinoma of the retromolar trigone with a depth of invasion of 2 mm, no bone invasion, and negative margins. Due to the proximity of the presenting lesions, they were resected in a single en bloc specimen. The ipsilateral neck was dissected and pathologically negative (0/14 lymph nodes). The resulting

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Permanent alopecia after cranial irradiation: Dose–response relationship

Cited by 117 publications

References 26 publications

Health status of childhood leukemia survivors who received hematopoietic cell transplantation after BU or TBI: an LEA study

Health status of childhood leukemia survivors who received hematopoietic cell transplantation after BU or TBI: an LEA study

Dermoscopy of multiple radiation-induced basal cell carcinomas in a patient treated previously for pinealoma

Intensity-modulated radiation therapy for permanent alopecia of unwanted palatal hair

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