2004
DOI: 10.1159/000075029
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Perlecan Functions in Chondrogenesis: Insights from in vitro and in vivo Models

Abstract: Perlecan is a large heparan sulfate proteoglycan that is typically found in basal lamina of adult and embryonic tissues. Recent studies have demonstrated that perlecan accumulates impressively during cartilage development and is maintained as the major heparan sulfate proteoglycan of adult cartilage. In vertebrates, perlecan mutations result in skeletal defects. Moreover, in vitro studies indicate that perlecan can stimulate early stages of cartilage differentiation and cooperate with chondrogenic growth facto… Show more

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Cited by 36 publications
(33 citation statements)
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“…The presence of cells expressing the 4C3 and 7D4 CS sulfation motifs within the presumptive articular cartilage and perichondrial tissue of the fetal elbow observed in this study provides further evidence of these as developmental markers. Perlecan also has a widespread distribution in articular cartilage and promotes chondrogenesis [52][53][54][55][56]. Perlecan was found localized to the surface regions of the perichondrium in this study where it may provide a unique niche microenvironment conducive to the maintenance of progenitor cell populations underlying the fibrous perichondrium [42,43].…”
Section: Discussionmentioning
confidence: 79%
“…The presence of cells expressing the 4C3 and 7D4 CS sulfation motifs within the presumptive articular cartilage and perichondrial tissue of the fetal elbow observed in this study provides further evidence of these as developmental markers. Perlecan also has a widespread distribution in articular cartilage and promotes chondrogenesis [52][53][54][55][56]. Perlecan was found localized to the surface regions of the perichondrium in this study where it may provide a unique niche microenvironment conducive to the maintenance of progenitor cell populations underlying the fibrous perichondrium [42,43].…”
Section: Discussionmentioning
confidence: 79%
“…Perlecan also acts as a low affinity co-receptor for fibroblast growth factors (FGFs)-1, 2, 7, 9 and binds connective tissue growth factor (CTGF). The FGFs have potent cell proliferative and matrix synthesis promoting properties (Klint and Claessen-Welsh 1999;Chang et al 2000;Knox et al 2001Knox et al , 2002Hassell et al 2002); furthermore, CTGF modulates bone morphogenetic protein and transforming growth factor (TGF)-b signalling and co-ordinates chondrogenesis and angiogenesis during skeletal development (Abreu et al 2002;Ivkovic et al 2003;Nishida et al 2003;Gomes et al 2004). …”
Section: Discussionmentioning
confidence: 99%
“…However, to date there has been no detailed analysis of cartilage structures in these animals. Furthermore, it is possible that domain V of perlecan, which can carry HS chains under some circumstances [12,59], may compensate for the lack of domain I HS [60]. In support of this, perlecan isolated from the kidneys of these same perlecan-HS-deficient mice was recently shown to be substituted with either HS or CS [61].…”
Section: What Is the Role Of Perlecan Hs In Chondrogenesis?mentioning
confidence: 98%