Periventricular venous density in multiple sclerosis is inversely associated with T2 lesion count: a 7 Tesla MRI study

Sinnecker, Tim; Bozin, Ivan; Dörr, Jan; Pfueller, Caspar F.; Harms, Lutz; Niendorf, Thoralf; Brandt, Alexander U.; Paul, Friedemann; Wuerfel, Jens

doi:10.1177/1352458512451941

Cited by 54 publications

(59 citation statements)

References 37 publications

(73 reference statements)

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“…PVA was not associated with gender in healthy control subjects (p=0.713), which is in agreement with previous published results [14]. However, we observed a trend towards smaller PVA values in older healthy control subjects (r=-0.458, p=0.074).…”

Section: Periventricular Vascular Area In Healthy Control Subjects Nsupporting

confidence: 92%

“…To estimate the periventricular venous density, we decided to use a manual approach since signal inhomogeneities on 7T T2*w images impact automated segmentation procedures. The periventricular vascular area (PVA) was assessed as described previously ( Figure 1) [14]. In brief, a minimal intensity projection map (MIP) of the two adjacent axial T2*w slices that are tangential to the roof of the lateral ventricles was calculated first.…”

Section: Image Analysismentioning

confidence: 99%

“…The investigator then manually marked each venous voxel with a signal intensity of less than 10% of the mean signal intensity of the neighbouring normal appearing vein-free white matter. The applied 10% threshold builds on previous reports [14]. To determine the mean signal intensity of the neighbouring normal appearing vein-free white matter, multiple ellipsoid ROIs with an area of 2mm 2 were used as a reference.…”

Section: Image Analysismentioning

confidence: 99%

“…In MS, a reduced visibility of the cerebral venous system was reported recently [14,15]. The reason for diminished visibility of the venous vasculature on 7T T2*w images in MS remains to be clarified.…”

Section: Introductionmentioning

confidence: 96%

“…The reason for diminished visibility of the venous vasculature on 7T T2*w images in MS remains to be clarified. It may result from a reduced oxygen consumption as consequence of a widespread cerebral gliosis and hypometabolic state, leading to a reduced deoxygenation of the brain's venous blood and thus less susceptibility related signal loss on T2*w images [14,15].…”

Section: Introductionmentioning

confidence: 99%

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Neuromyelitis optica does not impact periventricular venous density versus healthy controls: a 7.0 Tesla MRI clinical study

Schumacher

Pache

Bellmann‐Strobl

et al. 2016

Magn Reson Mater Phy

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Object:To quantify the periventricular venous density in neuromyelitis optica spectrum disease (NMOSD) in comparison to multiple sclerosis (MS) and healthy control subjects. Materials and Methods:Sixteen NMOSD, sixteen MS and sixteen healthy control subjects (HC) underwent 7.0 Tesla (7T) MRI. The imaging protocol included T 2 * weighted (T2*w) fast low angle shot (FLASH) and fluid attenuated inversion recovery (FLAIR) sequences. The periventricular venous area (PVA) was manually determined by a blinded investigator in order to estimate the periventricular venous density in a region-of-interest based approach. Results:No significant differences in periventricular venous density indicated by PVA were detectable in NMOSD versus healthy controls (p=0.226). In contrast, PVA was significantly reduced in MS patients compared to HC (p=0.013). Conclusion:Unlike in MS, patients suffering from NMOSD did not show a reduced venous visibility.This finding may underscore primary and secondary pathophysiological differences between these two distinct diseases of the central nervous system. 5

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Section: Periventricular Vascular Area In Healthy Control Subjects Nsupporting

confidence: 92%

Section: Image Analysismentioning

confidence: 99%

Section: Image Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Neuromyelitis optica does not impact periventricular venous density versus healthy controls: a 7.0 Tesla MRI clinical study

Schumacher

Pache

Bellmann‐Strobl

et al. 2016

Magn Reson Mater Phy

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Use of Advanced Magnetic Resonance Imaging Techniques in Neuromyelitis Optica Spectrum Disorder

et al. 2015

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Brain parenchymal lesions are frequently observed on conventional magnetic resonance imaging (MRI) scans of patients with neuromyelitis optica (NMO) spectrum disorder, but the specific morphological and temporal patterns distinguishing them unequivocally from lesions caused by other disorders have not been identified. This literature review summarizes the literature on advanced quantitative imaging measures reported for patients with NMO spectrum disorder, including proton MR spectroscopy, diffusion tensor imaging, magnetization transfer imaging, quantitative MR volumetry, and ultrahigh-field strength MRI. It was undertaken to consider the advanced MRI techniques used for patients with NMO by different specialists in the field.Although quantitative measures such as proton MR spectroscopy or magnetization transfer imaging have not reproducibly revealed diffuse brain injury, preliminary data from diffusionweighted imaging and brain tissue volumetry indicate greater white matter than gray matter degradation. These findings could be confirmed by ultrahigh-field MRI. The use of nonconventional MRI techniques may further our understanding of the pathogenic processes in NMO spectrum disorders and may help us identify the distinct radiographic features corresponding to specific phenotypic manifestations of this disease.

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7 Tesla MRI of Balo's concentric sclerosis versus multiple sclerosis lesions

Behrens

Wanner

Kuchling

et al. 2018

Ann Clin Transl Neurol

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BackgroundBaló's concentric sclerosis (BCS) is a rare condition characterized by concentrically layered white matter lesions. While its pathogenesis is unknown, hypoxia‐induced tissue injury and chemotactic stimuli have been proposed as potential causes of BCS lesion formation. BCS has been suggested to be a variant of multiple sclerosis (MS). Here, we aimed to elucidate similarities and differences between BCS and MS by describing lesion morphology and localization in high‐resolution 7 Tesla (7 T) magnetic resonance imaging (MRI) scans.MethodsTen patients with Baló‐type lesions underwent 7 T MRI, and 10 relapsing remitting MS patients served as controls. The 7 T MR imaging protocol included 3D T1‐weighted (T1w) magnetization‐prepared rapid gradient echo, 2D high spatial resolution T2*‐weighted (T2*w) fast low‐angle shot and susceptibility‐weighted imaging.ResultsIntralesional veins were visible in the center of all but one Baló‐type lesion. Four Baló‐type lesions displayed inhomogeneous intralesional T2*w signal intensities, which are suggestive of microhemorrhages or small ectatic venules. Eight of 10 BCS patients presented with 97 additional lesions, 36 of which (37%) had a central vein. Lesions involving the cortical gray matter and the U‐fibers were not detected in BCS patients.ConclusionOur findings support the hypothesis that BCS and MS share common pathogenetic mechanisms but patients present with different lesion phenotypes.

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Periventricular venous density in multiple sclerosis is inversely associated with T2 lesion count: a 7 Tesla MRI study

Abstract: High spatially resolving anatomical T2*-weighted MRI revealed vascular alterations in early stages of multiple sclerosis, presumably as a part of widespread haemodynamic and metabolic alterations.

Cited by 54 publications

References 37 publications

Neuromyelitis optica does not impact periventricular venous density versus healthy controls: a 7.0 Tesla MRI clinical study

Neuromyelitis optica does not impact periventricular venous density versus healthy controls: a 7.0 Tesla MRI clinical study

Use of Advanced Magnetic Resonance Imaging Techniques in Neuromyelitis Optica Spectrum Disorder

7 Tesla MRI of Balo's concentric sclerosis versus multiple sclerosis lesions

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