Periventricular hemorrhage in a developing world is drug intervention appropriate?

Adhikari, Miriam; Gouws, Eleanor; Desai, Pragnya Kapilray

doi:10.1016/0387-7604(95)00016-5

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…Birth weight is a predictor of neonatal death, 19,20 causes of neonatal death, 21 and birth asphyxia 20,22 in less-developed countries. Gestational age also is a strong predictor of neonatal death.…”

Section: Discussionmentioning

confidence: 99%

High Mortality Rates for Very Low Birth Weight Infants in Developing Countries Despite Training

Carlo

Goudar

Jehan³

et al. 2010

Pediatrics

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OBJECTIVE The goal was to determine the effect of training in newborn care and resuscitation on 7-day (early) neonatal mortality rates for very low birth weight (VLBW) infants. The study was designed to test the hypothesis that these training programs would reduce neonatal mortality rates for VLBW infants. METHODS Local instructors trained birth attendants from 96 rural communities in 6 developing countries in protocol and data collection, the World Health Organization Essential Newborn Care (ENC) course, and a modified version of the American Academy of Pediatrics Neonatal Resuscitation Program (NRP), by using a train-the-trainer model. To test the impact of ENC training, data on infants of 500 to 1499 g were collected by using a before/after, active baseline, controlled study design. A cluster-randomized, controlled trial design was used to test the impact of the NRP. RESULTS A total of 1096 VLBW (500–1499 g) infants were enrolled, and 98.5% of live-born infants were monitored to 7 days. All-cause, 7-day neonatal mortality, stillbirth, and perinatal mortality rates were not affected by ENC or NRP training. CONCLUSIONS Neither ENC nor NRP training of birth attendants decreased 7-day neonatal, stillbirth, or perinatal mortality rates for VLBW infants born at home or at first-level facilities. Encouragement of delivery in a facility where a higher level of care is available may be preferable when delivery of a VLBW infant is expected.

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Section: Discussionmentioning

confidence: 99%

High Mortality Rates for Very Low Birth Weight Infants in Developing Countries Despite Training

Carlo

Goudar

Jehan³

et al. 2010

Pediatrics

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“…Intraventricular hemorrhage (IVH) within the brain's ventricles commonly occurs in 15-25% of low-birth-weight preterm infants and 45-50% of extremely low birth weight preterm [1][2][3]. Cranial or transfontanelle ultrasound (US) imaging through the fontanelles is the standard diagnostic tool, demonstrating near 100% sensitivity and 93% specificity for brain bleeds above 5% volume [4,5].…”

Section: Introductionmentioning

confidence: 99%

Development of a thermoacoustic imaging system to image blood in the brain: preliminary ex-vivo results

Islam,

Benavides,

Prakash

et al. 2024

Photons Plus Ultrasound: Imaging and Sensing 2024

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Thermoacoustic imaging (TAI) is a promising new technology for biomedical diagnostics. It combines the high contrast of electromagnetic absorption with the high resolution of ultrasound imaging. Traditional TAI systems use circular scanning modes with single or arc detectors, which can be slow and inefficient for body scanning. A linear-array detector, which is commonly used in medical ultrasound imaging systems, can be used to scan biological tissues more efficiently. In this study, we developed a novel linear-array TAI system (LATIS) for the detection of hemorrhage in the brain through fontanelle in neonates. The LATIS uses a linear-array transducer with multiple elements, which enables rapid data acquisition and real-time imaging. A custom-designed trigger mechanism synchronizes the microwave signal generation and data acquisition process, ensuring accurate timing for optimal image quality. We evaluated the LATIS performance by conducting several ex-vivo sheep brain hemorrhage of different amounts of artificially induced blood.The system was able to successfully detect lower grades of intraventricular hemorrhages in ex-vivo experiments. These results demonstrate the potential of LATIS for clinical imaging of brain hemorrhage in neonates as they are vulnerable to intraventricular hemorrhage.

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“…Intraventricular hemorrhage (IVH) and periventricular hemorrhage (PVH), jointly known as periventricular-intraventricular hemorrhage (PIVH), are common complications in preterm neonates. IVH applies to hemorrhages within the brain's ventricular system, and PVH applies to hemorrhages in the periventricular region [1] (see Fig. 1 ).…”

Section: Introductionmentioning

confidence: 99%

Transfontanelle photoacoustic imaging of intraventricular brain hemorrhages in live sheep

Benavides-Lara,

Manwar,

McGuire

et al. 2023

Photoacoustics

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Periventricular hemorrhage in a developing world is drug intervention appropriate?

Cited by 3 publications

References 9 publications

High Mortality Rates for Very Low Birth Weight Infants in Developing Countries Despite Training

High Mortality Rates for Very Low Birth Weight Infants in Developing Countries Despite Training

Development of a thermoacoustic imaging system to image blood in the brain: preliminary ex-vivo results

Transfontanelle photoacoustic imaging of intraventricular brain hemorrhages in live sheep

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