Perivascular injury leads to a reduction in vascular reactivity of the collared and to an enhancement on contralateral carotid artery of rats

Fukada, Sandra Yasuyo; Corrêa, Fernando M.A.; Ramalho, Leandra Náira Zambelli; Mizusaki, Cristina Ioshie; Oliveira, Ana Maria de

doi:10.1016/j.carpath.2004.07.001

Cited by 10 publications

(18 citation statements)

References 27 publications

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“…Our findings are in agreement with previous studies describing reduced contraction for several agonists such as endothelin-1, phenylephrine and angiotensin II in injured arteries (Milner et al, 1997;Accorsi-Mendonça et al, 2004;Fukada et al, 2004a;2004b).…”

Section: Discussionsupporting

confidence: 93%

“…Similarly, an increased response to phenylephrine and angiotensin II was observed in the contralateral carotid artery after perivascular injury induced by a silicone collar (Fukada et al, 2004a;2004b). Moreover, it was previously described that partial stenosis of carotids, due to the atherosclerosis process, increases the vascular reactivity of the carotid and cerebral arteries to contractile agonists (Muller et al, 1995;van Everdingen et al, 2000;de Nie et al, 2001).…”

Section: Introductionmentioning

confidence: 74%

“…Animal models of vascular occlusive diseases (Kennedy et al, 2006), as well as models of vascular injury (Milner et al, 1997;Accorsi-Mendonça et al, 2004;Fukada et al, 2004a;2004b), are associated with reduced contractility of the injured artery to catecholamines and angiotensin II. Interestingly, the effects of stenosis on the vascular responses to KCl were reported to be tissue and age-dependent (Asano et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

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Aging and total stenosis triggers differential responses of carotid and basilar arteries to endothelin-1 and phenylephrine

Andrade

Corrêa

Oliveira

2009

J. Smooth Muscle Res.

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Our aim was to investigate the effects of ageing on the vascular contractility of carotid and basilar arteries from guinea-pigs, in a model of total stenosis. Moreover, we attempted to identify whether total stenosis of the left common carotid (stenosed) in adult guinea-pigs, would affect the contractions of contralateral carotid (intact) and basilar arteries to different vasoconstrictors. With this purpose, the left carotid was occluded with a silk thread at a position close to its origin. Vascular reactivity experiments using standard muscle bath were performed 7, 15, 30, and 90 days after carotid occlusion. Reactivity of carotid and basilar arteries to endothelin-1, phenylephrine and KCl was reduced with ageing in naive guinea-pigs. The endothelin-1 and KCl-induced contractions were unaltered in arteries from SHAM-operated animals. Moreover, phenylephrine-induced contractions were reduced in both carotids from 7 days SHAM-operated guinea-pigs, when compared to naive group. Stenosis induced progressive reduction in the contraction induced by endothelin-1, phenylephrine and KCl in the stenosed carotid, when compared to their respective age-matched naive and SHAM groups. Interestingly, an increased contractile-response to vasoconstrictor agents in all the contralateral carotids was observed. Stenosis (30 and 90 days) also induced an increase in the contractions induced by endothelin-1 in the basilar artery. Conversely, phenylephrine and KCl-induced contractions were reduced in basilar arteries 7, 15, 30 and 90 days after stenosis. These results showed that stenosis in adult guinea-pigs induce alterations of vascular reactivity in arteries distant from the site of injury. Thus, in spite of the common use of contralateral carotid as control, it must be aware of the potential alteration induced by stenosis in the vascular motility of such vessels. Additionally, it was verified a relationship between the period of stenosis and the alterations in the vascular reactivity to these vasoconstrictors.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 99%

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Aging and total stenosis triggers differential responses of carotid and basilar arteries to endothelin-1 and phenylephrine

Andrade

Corrêa

Oliveira

2009

J. Smooth Muscle Res.

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“…Fukada et al (2004) observaram que o implante de colar de silicone em artéria carótida de rato promoveu aumento de efeito máximo para Phe na artéria contra-lateral, 4 dias após o implante. No processo de estenose total em artéria carótida de cobaio, de Andrade (2008) verificaram que, após 90 dias, existe aumento de efeito máximo para Phe na contralateral.…”

Section: -Revisão Da Literaturaunclassified

“…No processo de estenose total em artéria carótida de cobaio, de Andrade (2008) verificaram que, após 90 dias, existe aumento de efeito máximo para Phe na contralateral. Fukada et al (2004) e de Andrade (2008) sugerem existência de mecanismos compensatórios complexos e pouco conhecidos, ativados na artéria contra-lateral após a injúria vascular.…”

Section: -Revisão Da Literaturaunclassified

Mecanismos celulares que influenciam a sinalização por receptores 1-adrenérgicos na carótida contra-lateral à lesão por cateter balão

Pereira¹

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Adventitia: the vital wall of conduit arteries

Gingras

Farand

Safar³

et al. 2009

Journal of the American Society of Hypertension

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Perivascular injury leads to a reduction in vascular reactivity of the collared and to an enhancement on contralateral carotid artery of rats

Cited by 10 publications

References 27 publications

Aging and total stenosis triggers differential responses of carotid and basilar arteries to endothelin-1 and phenylephrine

Aging and total stenosis triggers differential responses of carotid and basilar arteries to endothelin-1 and phenylephrine

Mecanismos celulares que influenciam a sinalização por receptores 1-adrenérgicos na carótida contra-lateral à lesão por cateter balão

Adventitia: the vital wall of conduit arteries

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