Perivascular epithelioid cell tumor of the uterine cervix identified on a conventional cervical smear

Tajima, Shogo; Koda, Kenji

doi:10.1002/dc.23369

Cited by 10 publications

(5 citation statements)

References 17 publications

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“…Perivascular epithelioid cell tumor occurs in a variety of sites, especially common in liver, prostate, and uterine cervix. [ 9 – 11 ] The PEComa family of tumors includes angiomyolipoma, lymphangioleiomyomatosis, clear cell sugar tumor of the lung, clear cell myomelanocytic tumor of the falciform ligament/ligamentum teres, and rare clear cell tumors of other anatomical sites (PEComas-NOS). [ 12 ] Pigmented PEComa of the kidney was unusual and first reported by Fujimoto et al [ 13 ] It manifests in older patients, with an average age of 44 and a female predominance.…”

Section: Discussionmentioning

confidence: 99%

Pigmented perivascular epithelioid cell tumor (PEComa) arising from kidney

Zhou²,

Xu³

et al. 2016

Medicine

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Introduction:Perivascular epithelioid cell tumor (PEComa) is a mesenchymal neoplasm composed of perivascular epithelioid cells with clear to eosinophilic cytoplasm. Pigmented PEComa arising from kidney is extraordinarily rare and sometimes can exhibit aggressive biological behavior.Case report:We present here a rare case of pigmented renal PEComa in a 46-year-old female. The patient had complained of lumbago complicated with nausea and vomiting for 2 weeks and therefore was referred to our department. An enhanced computed scan revealed a 4 × 3 × 3 cm round-like mass in the lower pole of right kidney with inhomogeneous enhancement. The tumor cells immunestained was positive for HMB-45, focally positive for c-Kit (CD117), and negative for vimentin, S-100, AE1/AE3, CK-7, CK-18, CD-10, RCC antigen, CgA, DOG-1, EMA, smooth muscle actin, and synaptophysin. We successfully performed 3-dimensional laparoscopic resection of the neoplasm, which was then diagnosed as pigmented PEComa by postoperative pathology. No further growing lesion or metastasis was observed during a 1-year follow-up.Conclusion:This case report shows that pigmented renal PEComa is often presented as a renal mass with nonspecific symptoms and imaging features. The gold diagnosis of renal pigmented PEComa is mainly based on the combination of histopathology and immunohistochemistry. Complete resection by 3-dimensional laparoscopic nephron-sparing surgery can be an effective therapeutic management.

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Section: Discussionmentioning

confidence: 99%

Pigmented perivascular epithelioid cell tumor (PEComa) arising from kidney

Zhou²,

Xu³

et al. 2016

Medicine

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“…Cytological diagnosis of cervical PEComa is even rarer. So far, only two cases of PEComa diagnosed by conventional cervical smears have been reported in the available English literature [3][4]. We report a case of cervix PEComa identi ed by the liquid-based cytology test, cell blocks, and immunohistochemistry in a 55-year-old postmenopausal woman.…”

Section: Introductionmentioning

confidence: 92%

Perivascular epithelioid cell tumor of the uterine cervix identified on the liquid-based cytology: a case report

Tang

Feng

Shen

et al. 2022

Preprint

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Background: Perivascular epithelioid cell tumours (PEComa) occurring in the female genital tract are rare, typically found in the uterine corpus. PEComa occurring in the cervix are extremely rare, and very few cases have been reported till now.Cytological diagnosis of cervical PEComa is even rarer. So far, only two cases of PEComa diagnosed by conventional cervical smears have been reported.Case presentation: A 55-year-old postmenopausal women presented with abnormal vagina discharges for three months. Then, a liquid-based cytology test was performed. Microscopically, some loosely cohesive epithelioid cells were uniform with abundant clear cytoplasm, showed predominantly round or oval nuclei with nely stippled chromatin, and distinct round nucleoli were visible in some cells, notably with numerous melanin pigments in the cytoplasm. The cytopathological features were well correlated with cell blocks and histopathological ndings. Upon immunohistochemistry, the tumor cells were positive for HMB45, TFE3, focally positive for MelanA, while negative for muscle marker. Fluorescence in situ hybridization (FISH) con rmed TFE3 gene rearrangement. The nal pathological diagnosis was PEComa identi ed by the liquid-based cytology, cell blocks, immunohistochemistry and FISH. The patient underwent a total hysterectomy with bilateral salpingo-oophorectomy and was followed up for two years with no evidence of disease. Conclusion:The cytologic characteristics of the tumor may provide su cient clues for diagnosing a PEComa, including loosely cohesive, epithelioid morphology with abundant clear cytoplasm or eosinophilic cytoplasm, low-grade nuclear atypia, cytoplasmic melanin pigment. That will help cytopathologists recognize this rare tumor that occurred in the cervix, combined with results of other detection methods, can achieve the de nitive diagnosis of PEComa.

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“…Currently, there are several cases that the early diagnosis of cervical PEComa has been achieved through the use of routine cervical smears. 6,27,28 However, this method is not applicable for the diagnosis of PEComa originated from uterine body. Uterus PEComa can be diagnosed by histological and immunohistochemical features, but preoperative diagnosis can be challenging.…”

Section: Diagnosismentioning

confidence: 99%

A Case Report of Malignant Perivascular Epithelioid Cell Tumors of the Uterus and Literature Review

Hu,

Miao,

Zhou

et al. 2024

IJWH

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Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal tumors originating from perivascular epithelioid cells. In gynecological system, the uterus is one of the most common sites affected by PEComas. Most PEComas are benign, and patients usually have a good prognosis. However, malignant uterus PEComa is rare, and better comprehensive epidemiological investigations are needed. To date, there are a few reported cases of uterus PEComa. We herein report a rare case of malignant PEComa occurred in the uterine corpus and cervix, possibly accompanied by pulmonary lymphangioleiomyomatosis (PLAM). In addition, 55 cases of malignant uterus PEComa were picked out and collected in the data base of PubMed and Medline. On the one hand, the age of onset, population distribution, clinical manifestations, metastatic sites and routes of metastasis were analysed. On the other hand, a summary of the epidemiology, pathogenesis, diagnosis, and treatments of uterus PEComa was given.

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Perivascular epithelioid cell tumor of the uterine cervix identified on a conventional cervical smear

Cited by 10 publications

References 17 publications

Pigmented perivascular epithelioid cell tumor (PEComa) arising from kidney

Pigmented perivascular epithelioid cell tumor (PEComa) arising from kidney

Perivascular epithelioid cell tumor of the uterine cervix identified on the liquid-based cytology: a case report

A Case Report of Malignant Perivascular Epithelioid Cell Tumors of the Uterus and Literature Review

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