Perivascular Delivery of Paclitaxel with F-127 Pluronic Gel Inhibits Neointimal Hyperplasia in a Rat Carotid Artery Injury Model

Kwon, Jinhyeong; Park, Sung Soon; Kim, Young Gyu; Son, Ju Hee; Lee, Yeong Shin; Kim, Ki-Seok; Hwang, Kyung Kuk; Kim, Dong Ho; Cho, Myeong Chan

doi:10.4070/kcj.2005.35.3.221

Cited by 6 publications

(2 citation statements)

References 21 publications

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“…Drug-eluting bioabsorbable vascular wrap showed promising results in surgically-placed dialysis grafts in sheep [ 13 ]. Furthermore, Kwon et al [ 14 ] and Park et al [ 15 ] reported that perivascular delivery of antiproliferative agents such as rapamycin or paclitaxel with F-127 pluronic gel successfully inhibited neointimal hyperplasia following carotid artery injury in rats. Our study, on the other hand, employed fibrin glue as a vehicle to deliver paclitaxel over an extended period of time.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effect of sustained perivascular delivery of paclitaxel on neointimal hyperplasia in the jugular vein after open cutdown central venous catheter placement in rats

Kim

Hwang

et al. 2017

Ann Surg Treat Res

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PurposeInhibitory effect of paclitaxel on neointimal hyperplasia after open cutdown has not been elucidated.MethodsFor the control group (n = 16), silicone 2.7-Fr catheters were placed via the right external jugular vein with the cutdown method. For the treatment group (n = 16), a mixture of 0.65 mg of paclitaxel and 1 mL of fibrin glue was infiltrated around the exposed vein after cutdown. After scheduled intervals (1, 2, 4, and 8 weeks), the vein segment was harvested and morphometric analysis was performed on cross-sections.ResultsProliferation of smooth muscle cell (SMC) was strongly suppressed in the treatment group, and the ratio of neointima to vein wall was significantly reduced in the treatment group (8 weeks; 0.63 ± 0.08 vs. 0.2 ± 0.08, P < 0.05). Luminal patency was significantly more preserved in the treatment group, and the luminal area was significantly wider in the paclitaxel-treated group compared to the control group (8 weeks; 1.91 ± 0.43 mm2 vs. 5.1 ± 0.43 mm2, P < 0.05). Mean SMC counts measured at 1 and 2 weeks after cutdown were significantly lower in the treatment group (2 weeks; 115 ± 22 vs. 62 ± 22). Paclitaxel was undetectable in systemic circulation (<10 ng/mL).ConclusionSustained perivascular delivery of paclitaxel with fibrin glue was effective in inhibiting neointimal hyperplasia in rat jugular vein after open cutdown.

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Section: Discussionmentioning

confidence: 99%

Inhibitory effect of sustained perivascular delivery of paclitaxel on neointimal hyperplasia in the jugular vein after open cutdown central venous catheter placement in rats

Kim

Hwang

et al. 2017

Ann Surg Treat Res

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“…Drug-eluting bioabsorbable vascular wrap showed promising results in animal studies [ 8 ]. Kwon et al [ 9 ] reported that perivascular delivery of paclitaxel with F-127 pluronic gel inhibited neointimal hyperplasia in a rat carotid artery injury model. Pluronic F-127 consists by weight of approximately 70% ethylene oxide and 30% propylene oxide with an average molecular weight of 11,500.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of intimal hyperplasia by local perivascular application of rapamycin and imatinib mesilate after carotid balloon injury

et al. 2013

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PurposeInhibition of the intimal hyperplasia after vascular surgery is an important issue. The purpose of this study is to define whether perivascular application of rapamycin, imatinib mesylate or cysteamine can reduce intimal hyperplasia in a carotid balloon injury model.MethodsEach drug was mixed with 40% pluronic gel solution and was topically applied over the injured carotid artery evenly. Two or four weeks after injury, the arteries were harvested and morphometric analysis was done.ResultsThe medial areas were not significantly different in each group and a thinning of the media as a toxic drug effect was not observed in any treatment group. The intimal area and intima-to-media (I/M) ratio were significantly reduced in rapamycin-treated group and imatinib-treated group (P < 0.05). But cysteamine-treated group showed a trend of decrease in I/M ratio in 2 weeks, but no difference in 4 weeks.ConclusionPerivascular delivery of imatinib or rapamycin with pluronic gel attenuated the development of intimal hyperplasia. But cysteamine did not. Further studies are needed to refine the optimal drug dosages in large animal models.

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A Slight Variation in the Age of Rats Commonly used as a Carotid Artery Injury Model Results in a Large Difference in Neointima Formation

et al. 2007

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Background and Objectives：The degree of neointima formation after infliction of a carotid artery balloon injury in rats varies greatly depending on the sex, age, species and operational method. Strong variation is common, even within only a single control. This study attempted to find if there was any significant difference in neointima formation following a carotid artery balloon injury in 6 to 12 week old rats; the age commonly used in these types of experiments. Materials and Methods：A balloon injury was inflicted on the carotid arteries of male SpragueDawley rats at 6 (n=9, 250-270 g), 8 (n=8, 280-300 g) and 11 weeks (n=10, 320-340 g) of age. Two weeks postoperation, a histomorphometric analysis was carried out. The vascular smooth muscle cell proliferation was measured in situ via BrdU incorporation 2 days after injury infliction. Results：The neointima areas of the 6 week (0.22±0.04 mm

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Perivascular Delivery of Paclitaxel with F-127 Pluronic Gel Inhibits Neointimal Hyperplasia in a Rat Carotid Artery Injury Model

Cited by 6 publications

References 21 publications

Inhibitory effect of sustained perivascular delivery of paclitaxel on neointimal hyperplasia in the jugular vein after open cutdown central venous catheter placement in rats

Inhibitory effect of sustained perivascular delivery of paclitaxel on neointimal hyperplasia in the jugular vein after open cutdown central venous catheter placement in rats

Inhibition of intimal hyperplasia by local perivascular application of rapamycin and imatinib mesilate after carotid balloon injury

A Slight Variation in the Age of Rats Commonly used as a Carotid Artery Injury Model Results in a Large Difference in Neointima Formation

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