Perivascular cells function as mechano-structural sensors of vascular capillaries
Cristiane M. Franca,
Maria Elisa Lima Verde,
Alice Correa Silva-Sousa
et al.
Abstract:A wide range of conditions, including chronic inflammatory diseases and cancer, are characterized by the fibrotic microarchitecture and increased stiffness of collagen type I extracellular matrix. These conditions are typically accompanied by altered vascular function, including vessel leakiness, abnormal capillary morphology and stability. The dynamic cell-matrix interactions that regulate vascular function in healthy tissues have been well documented. However, our understanding of how the gradual mechanical … Show more
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