Perivascular adipose tissue in age-related vascular disease

Queiroz, Marcelo; Sena, Cristina M.

doi:10.1016/j.arr.2020.101040

Cited by 51 publications

(33 citation statements)

References 161 publications

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“…PVAT may have a paracrine function in the regulation of arterial tone, vascular reactivity, and more. 76 This paracrine adipose-vascular coupling is achieved by the production and function of various ADRFs, which might be a volatile, gaseous mediator, namely, H 2 S. 75 There is evidence that the opening of myocyte K + channels plays a critical role in the paracrine regulation of arterial tone by H 2 S. KCNQ (Kv7) channels could represent, at least in part, the subtypes of the voltage-dependent K + (Kv) channels involved. 77 Additional ion channels, such as Ca 2+ -activated K + (K + -Ca 2+ ) channels, and cellular mechanisms appear to be involved in the vasoactive effects.…”

Section: Dovepressmentioning

confidence: 99%

<p>Hydrogen Sulfide, Adipose Tissue and Diabetes Mellitus</p>

Zhu¹,

Yang²,

Ma³

et al. 2020

DMSO

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Hydrogen sulfide (H 2 S) is now increasingly considered to be the third gasotransmitter alongside other gaseous signaling molecules, nitric oxide (NO) and carbon monoxide (CO). H 2 S is produced by a variety of endogenous enzymatic and non-enzymatic pathways and acts as a modulator of the physiological and pathological events of the body. Adipocytes express the cystathionine γ lyase (CSE)/H 2 S system, which modulates a variety of biological activities in adipose tissue (AT), including inflammation, apoptosis, insulin resistance, adipokine secretion and adipocyte differentiation. Abnormalities in the physiological functions of AT play an important role in the process of diabetes mellitus. Therefore, this review provides an overview of the general aspects of H 2 S biochemistry, the effect of H 2 S on AT function and diabetes mellitus and its molecular signalling mechanisms as well as the potential application of H 2 S in pharmacotherapy.

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Section: Dovepressmentioning

confidence: 99%

<p>Hydrogen Sulfide, Adipose Tissue and Diabetes Mellitus</p>

Zhu¹,

Yang²,

Ma³

et al. 2020

DMSO

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“…PVAT is a well-recognized regulator of vessel homeostasis and its dysfunction may strongly influence the pathogenesis of vascular diseases 21,22 . Herein, we tested on a genome-wide scale whether distinctive gene expression patterns were associated with the PVAT surrounding occlusive and stenotic segments of the abdominal aorta in PAD patients.…”

Section: Discussionmentioning

confidence: 99%

Gene-expression profiles of abdominal perivascular adipose tissue distinguish aortic occlusive from stenotic atherosclerotic lesions and denote different pathogenetic pathways

Piacentini

Saccu

Bono

et al. 2020

Sci Rep

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Perivascular adipose tissue (PVAT) helps regulate arterial homeostasis and plays a role in the pathogenesis of large vessel diseases. In this study, we investigated whether the PVAT of aortic occlusive lesions shows specific gene-expression patterns related to pathophysiology. By a genomewide approach, we investigated the PVAT transcriptome in patients with aortoiliac occlusive disease. We compared the adipose layer surrounding the distal aorta (atherosclerotic lesion) with the proximal aorta (plaque-free segment), both within and between patients with complete aortoiliac occlusion (Oc) and low-grade aortic stenosis (St). We found that PVAT of the distal versus proximal aorta within both Oc-and St-patients lacks specific, locally restricted gene-expression patterns. Conversely, singular gene-expression profiles distinguished the PVAT between Oc-and St-patients. Functional enrichment analysis revealed that these signatures were associated with pathways related to metabolism of cholesterol, vessel tone regulation, and remodeling, including TGF-β and SMAD signaling. We finally observed that gene-expression profiles in omental-visceral or subcutaneous fat differentiated between Oc-and St-patients, suggesting that the overall adipose component associates with a different atherosclerosis burden. Our work points out the role of PVAT and, likely, other adipose tissues play in the pathophysiological mechanisms underlying atherosclerotic disease, including the abdominal aortic occlusive forms.Common pathologies of the distal abdominal aorta include the dilated (aneurysmal) and the obstructive (atherosclerotic) forms 1,2 . Although the two conditions share some vascular risk factors (eg, cigarette smoking, hypertension, dyslipidemia), both epidemiology 3,4 and pathogenesis 5-7 of the diseases are clearly different. Even so, increasing evidences suggest that dysfunctional perivascular adipose tissue (PVAT) participates in the development and progression of both atherosclerotic and nonatherosclerotic vascular diseases 8,9 , including those affecting the distal abdominal aorta.PVAT is known to influence artery homeostasis by tuning many physiological functions, which comprise the regulation of vessel tone through the activation of pro-or anti-contractile mechanisms, secretion of soluble factors, and modulation of local inflammation 10 , and its dysfunction may adversely affect vessel health. PVAT is highly heterogeneous and its pathophysiological roles may be different depending on the segments of the artery beds 11 . Gene expression dataset. Following the probe-filtering criteria, we identified 18149 expressed probes.After re-annotation, we obtained a final expression matrix of 14352 transcripts, which correspond to 11105 unique genes (annotation details in the online-only Data Supplement 2). Adipose tissue samples clustering by principal component analysis (PCA) on whole gene-expression data.We used the entire, adjusted gene-expression matrix of PVAT, subcutaneous and omental-visceral adipose tissue (AT) samples of the PAD p...

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“…Increased expression levels of leptin and resistin can activate the expression of proinflammatory cytokines such as MCP-1, IL-6, IL-2, and TNF-α, all of which could act as pro-atherogenic molecules and promote vascular inflammation via monocyte migration and activation of macrophage [ 58 ]. Moreover, adipokines could alter the effective functions of insulin on vessels through affect the capillary recruitment [ 59 ]. These causal links could induce metabolic syndrome or atherosclerosis that can lead to MI or stroke in patients with psoriasis and PsA ( Figure 1 ).…”

Section: The Risk Of Cardiovascular Disease and Metabolic Syndromementioning

confidence: 99%

The Risk of Systemic Diseases in Those with Psoriasis and Psoriatic Arthritis: From Mechanisms to Clinic

Woo

Park

Kang

et al. 2020

IJMS

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Psoriasis and psoriatic arthritis (PsA) have been recently considered as chronic systemic inflammatory disorders. Over the past decades, enormous evidence indicates that patients with psoriasis and PsA have a higher risk of developing various comorbidities including cardiovascular disease, metabolic disease, cancers, infections, autoimmune disease, and psychiatric diseases. However, reported risks of some comorbidities in those with psoriasis and PsA are somewhat different according to the research design. Moreover, pathomechanisms underlying comorbidities of those with psoriasis and PsA remain poorly elucidated. The purpose of this review is to provide the most updated comprehensive view of the risk of systemic comorbidities in those with psoriasis and PsA. Molecular mechanisms associated with the development of various comorbidities in those with psoriasis and PsA are also reviewed based on recent laboratory and clinical investigations. Identifying the risk of systemic comorbidities and its associated pathomechanisms in those with psoriasis and PsA could provide a sufficient basis to use a multi-disciplinary approach for treating patients with psoriasis and PsA.

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Perivascular adipose tissue in age-related vascular disease

Cited by 51 publications

References 161 publications

<p>Hydrogen Sulfide, Adipose Tissue and Diabetes Mellitus</p>

<p>Hydrogen Sulfide, Adipose Tissue and Diabetes Mellitus</p>

Gene-expression profiles of abdominal perivascular adipose tissue distinguish aortic occlusive from stenotic atherosclerotic lesions and denote different pathogenetic pathways

The Risk of Systemic Diseases in Those with Psoriasis and Psoriatic Arthritis: From Mechanisms to Clinic

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