We report a case of a periurethral abscess caused by an ulcer at the glans penis successfully treated by chemotherapy and in addition by puncture of the liquified abscess. Diagnosis was made by ultrasound as the first-step imaging system, the exact time point for abscess puncture was determined by computer tomography. Periurethral abscess is a very rare pathological entity; to our knowledge there is no reported case of a nonvenereological ulcer as the primary lesion.