Peritumoral brain edema associated with meningioma

Yoshioka, Hiroyuki; Hama, Seiji; Taniguchi, Eiji; Sakamoto, Kazuhiko; Arita, Kazunori; Kurisu, Kaoru

doi:10.1002/(sici)1097-0142(19990215)85:4<936::aid-cncr23>3.0.co;2-j

Cited by 160 publications

(23 citation statements)

References 40 publications

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“…The present work showed that the studied cohort of meningioma patients had some demographic and clinicopathological criteria in common with meningioma patients from other countries, including predominant affection of adult female patients with supratentorial cerebral convexities being the most common site [2, 11, 12]; rarity in pediatric population [13]; infrequency of macrocysts [14]; predominance of benign grade I histology [2, 11, 12]; frequency of basal meningiomas [15]; and frequency of spinal meningiomas and their higher predilection for females, dorsal spine affection, and predominant benign histology [16]. …”

Section: Discussionmentioning

confidence: 91%

Biological and Demographic Profile of Meningiomas in a Cohort of Egyptian Patients: Impact on Tumor Recurrence

Abdelzaher

Deeb

Gowil

et al. 2013

The Scientific World Journal

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Objective. This work was designed to study the biological and demographic characteristics of meningiomas and their impact on tumor recurrence in Egyptian patients. Material and Methods. A cohort of 265 Egyptian patients with meningioma was studied. Immunohistochemistry for VEGF, Ki67, PR, CD20, and CD3 was performed. Statistical analysis was used to detect independent predictors of recurrence. Results. Adults represented 98.9% of cases, with female preponderance (M : F ratio = 1 : 2.4). Histologically, 78.10% of cases were grade I, 19.20% were grade II, and 2.60% were grade III. Transitional variant was the most common (43.40%). VEGF expression (38.50% of cases) correlated positively with perifocal edema, tumor size, and proliferative index (PI). PR expression (64.5% of cases) correlated inversely with the PI (mean 3.75). Lymphocytic aggregates were detected in 7.20% of cases, with a mean CD20 : CD3 ratio of 1 : 10.1. In a multivariate analysis, only tumor size, PR expression and necrosis predicted recurrence independently. Using ROC curve, size was the best predictor of tumor recurrence with a cut-off point of >6 cm and an excellent negative predictive value (97.6%). Conclusions. Meningiomas in our region showed some distinctive clinicopathological and demographic criteria. Tumor size was found to be the best recurrence predictor factor of meningioma.

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Section: Discussionmentioning

confidence: 91%

Biological and Demographic Profile of Meningiomas in a Cohort of Egyptian Patients: Impact on Tumor Recurrence

Abdelzaher

Deeb

Gowil

et al. 2013

The Scientific World Journal

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“…5,11,29,37,38 Vasogenic peritumoral edema in meningioma is believed to be related to angiogenesis and increased pial blood supply, and has been associated with increased expression of vascular endothelial growth factor, metallo-proteinases 2 and 9, and aquaporins 4 and 5. 27,34,45–47,50,65,67 Two studies found edema to be most common with convexity or parasagittal meningiomas, 11,38 but another did not observe a relationship to location, 29 and no consistent association between edema and tumor size or pathological subtype is present across studies. 11,29,38,49 Some groups have also suggested a relationship between brain invasion and edema, 39,44 although it is unclear if edema resulting from tumor infiltration differs from vasogenic edema in meningiomas without invasion.…”

Section: Discussionmentioning

confidence: 99%

Seizures in supratentorial meningioma: a systematic review and meta-analysis

Englot¹,

Magill²,

Han³

et al. 2016

JNS

127

109

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Object Meningioma is the most common benign intracranial tumor, and patients with supratentorial meningioma frequently suffer from seizures. The rates and predictors of seizures in patients with meningioma have been significantly under-studied, even in comparison with other brain tumor types. Improved strategies for the prediction, treatment, and prevention of seizures in patients with meningioma is an important goal, because tumor-related epilepsy significantly impacts patient quality of life. Methods The authors performed a systematic review of PubMed for manuscripts published between January 1980 and September 2014, examining rates of pre- and postoperative seizures in supratentorial meningioma, and evaluating potential predictors of seizures with separate meta-analyses. Results The authors identified 39 observational case series for inclusion in the study, but no controlled trials. Preoperative seizures were observed in 29.2% of 4709 patients with supratentorial meningioma, and were significantly predicted by male sex (OR 1.74, 95% CI 1.30–2.34); an absence of headache (OR 1.77, 95% CI 1.04–3.25); peritumoral edema (OR 7.48, 95% CI 6.13–9.47); and non–skull base location (OR 1.77, 95% CI 1.04–3.25). After surgery, seizure freedom was achieved in 69.3% of 703 patients with preoperative epilepsy, and was more than twice as likely in those without peritumoral edema, although an insufficient number of studies were available for formal meta-analysis of this association. Of 1085 individuals without preoperative epilepsy who underwent resection, new postoperative seizures were seen in 12.3% of patients. No difference in the rate of new postoperative seizures was observed with or without perioperative prophylactic anticonvulsants. Conclusions Seizures are common in supratentorial meningioma, particularly in tumors associated with brain edema, and seizure freedom is a critical treatment goal. Favorable seizure control can be achieved with resection, but evidence does not support routine use of prophylactic anticonvulsants in patients without seizures. Limitations associated with systematic review and meta-analysis should be considered when interpreting these results.

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“…Tamiya et al [10] perceived that angiomatous meningioma as well as meningothelial, anaplastic and microcystic histologic subtypes showed higher edema than other histologic variants. In conventional meningioma, venous obstruction, pial-meningeal anastomoses, increased capillary permeability, sex hormones and their receptors in meningiomas, and the secretion of vascular endothelial growth factor (VEGF) contribute to peritumoral edema [711121314]. In angiomatous meningioma, it is hypothesized that increased capillary permeability due to hypervascularity and VEGF secretion may mainly affect brain edema [7].…”

Section: Discussionmentioning

confidence: 99%

Clinical and Radiological Characteristics of Angiomatous Meningiomas

Hwang

Kong

Seol

et al. 2016

Brain Tumor Res Treat

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BackgroundAngiomatous meningioma is a rare histological subtype of meningioma. Therefore, this specific medical condition is rarely reviewed in the literature. In the present work, we report the clinical and radiological features with postoperative outcomes of angiomatous meningioma.MethodsThis retrospective study included the patients who were pathologically diagnosed with angiomatous meningioma after surgical resection between February 2010 and September 2015 in our institute. We analyzed the clinical data, radiological manifestation, treatment and prognosis of all patients.ResultsThe 15 patients (5 males and 10 females) were diagnosed with angiomatous meningioma during the study period. The median age of patients at the time of surgery was 63 years (range: 40 to 80 years). According to Simpson classification, 7, 5, and 3 patients achieved Simpson grade I, II, and IV resection, respectively. In the follow-up period, recurrence was noted in one patient. Ten out of the 15 patients showed homogeneous enhancement. Two patients demonstrated cystic changes. There was no occurrence of calcification or hemorrhage in our patients. Characteristically, 14 out of 15 patients showed signal voids of vessels. Significant peritumoral edema was observed in the majority of tumors (67%).ConclusionAngiomatous meningiomas are rare benign meningioma. Brain images of angiomatous meningioma usually demonstrate signal void signs and peritumoral edema. In the present study, angiomatous meningiomas showed good prognosis after surgical resection.

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Peritumoral brain edema associated with meningioma

Cited by 160 publications

References 40 publications

Biological and Demographic Profile of Meningiomas in a Cohort of Egyptian Patients: Impact on Tumor Recurrence

Biological and Demographic Profile of Meningiomas in a Cohort of Egyptian Patients: Impact on Tumor Recurrence

Seizures in supratentorial meningioma: a systematic review and meta-analysis

Clinical and Radiological Characteristics of Angiomatous Meningiomas

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