Peritonsillar abscess caused by Nocardia asteroides

Adair, John C.; Amber, Ina J.; Johnston, Jonathan B.

doi:10.1128/jcm.25.11.2214-2215.1987

Cited by 10 publications

(4 citation statements)

References 6 publications

(6 reference statements)

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“…The predilection of this organism for the brain as a secondary site of infection has been reported with a frequency of at least 23% for metastasis following pulmonary infection (24). Despite this frequency, N. asteroides has been perceived as an unusual and opportunistic pathogen of limited significance (1,26). Thus, very little is known about the interactions of N. asteroides with the host brain.…”

mentioning

confidence: 99%

Site-specific growth of Nocardia asteroides in the murine brain

Ogata

Beaman

1992

Infect Immun

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The growth of Nocardia asteroides GUH-2 and two mutants (NG-49 and I-38-syn) in regions of the brains of BALB/c mice was determined by microdissection and viable counting. GUH-2 grew throughout the murine brain but at different growth rates that depended on the specific location. The rate of increase in total CFU per brain during GUH-2 infection was unaffected by the inoculum size; however, in five of eight brain regions, an alteration in the inoculum size resulted in altered nocardial growth rates. Mutant NG-49 showed a significantly slower rate of increase in total CFU per brain than did the parental strain, GUH-2, and significantly decreased growth rates in seven brain regions. Mutant 1-38-syn showed a rate of increase in total CFU per brain similar to that of the parental strain; however, this mutant grew significantly faster in the cerebellum and pons-medulla. Growth appeared to be a necessary precursor to the cellular damage that resulted in the variety of neurological disorders observed in mice infected with N. asteroides GUH-2, because mutant NG-49 exhibited a decreased ability to grow in specific regions of the brain and did not induce signs of neurological damage. In

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confidence: 99%

Site-specific growth of Nocardia asteroides in the murine brain

Ogata

Beaman

1992

Infect Immun

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“…Although pulmonar nocardiosis often starts with the invasion of the respiratory tract,5 it can also follow dental or periodontal infections and there is a report of nocardiosis with a peritonsillar abscess 6. In our patient, there was a purulent tonsillitis not responsive to empirical therapy for the most causative agents, suggesting an alternative resistant agent as the aetiology.…”

Section: Discussionmentioning

confidence: 59%

Nocardialung abscess in an immunocompetent adolescent

Soares¹,

Reis-Melo

Ferraz

et al. 2019

BMJ Case Rep

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The authors report a case of a lung abscess caused by Nocardia sp. in a previously healthy adolescent. A 17-year-old young man presented with tonsillitis that did not respond to β-lactamic antibiotic, dyspnoea and thoracic pain. The X-ray revealed a cavitation in the right pulmonary upper lobe. He was admitted and completed a 14-day empirical antimicrobial therapy for a pulmonar abscess, although no clinical recovery was observed. He then underwent pulmonary biopsy of the lesion and PCR analysis of the collected pulmonary tissue, which revealed the presence of Nocardia. This case emphasises the importance of considering nocardiosis in the differential diagnosis of a lung abscess, particularly if no response to empirical therapy is obtained.

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“…In humans, at least six basic forms of disease may be recognized following Nocardia infection: (i) pulmonary nocardiosis (2,7,32,38,134,190,237,287,350,356,393); (ii) systemic nocardiosis (involving two or more body sites) (15,22,36,51,165,166,202,220,319,330,357); (iii) CNS nocardiosis (43,44,50,52,133,138,142,153,184,194,198,219,309,310), (iv) extrapulmonary nocardiosis (3,23,48,137,147,180,216,234,259,317); (v) cutaneous, subcutaneous, and lymphocutaneous (sporotrichoid) nocardiosis (12,47,…”

Section: Clinical Aspects Of Nocardl4 Infectionsmentioning

confidence: 99%

“…In general, this category may be best considered separately from cutaneous, lymphocutaneous, and mycetomatous infections (64, 74,78,122,263,583,585). Although any anatomic site can become a focus for primary extrapulmonary nocardial infection (3,46,49,125,147,182,236,252,259,360,409,450,460,481,519,526,533,573,616,643,646,655,667,711,732), the brain, bone, eyes, heart, joints, and kidneys are the most frequently affected sites reported in the literature (78,122,263,586). As indicated above, the predilection of Nocardia spp.…”

Section: Extrapulmonary Nocardiosismentioning

confidence: 99%

Nocardia species: host-parasite relationships.

Beaman¹,

Beaman²

1994

Clinical Microbiology Reviews

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From the very beginning, there has been uncertainty over the taxonomic position of nocardioforms, i.e., bacteria that resemble Nocardia organisms. The specific taxonomy of isolates of this heterogenous group of organisms is still in flux and controversial (275, 278, 403, 404, 420, 584, 676, 699). During the ensuing 100 years, it has been shown that N. asteroides is a heterogeneous taxon (275, 403, 404, 420). It is not within the scope of this review to address this complex subject, yet it is important to note that N. asteroides, as currently defined, probably consists of several subtypes and/or species. These include N. asteroides sensu stricto, N. farcinica, N. nova, and several distinct serotypes and biotypes (278, 403, 404, 698, 699, 727). Regardless of their designation, all of these varieties of the N. asteroides taxon have been isolated from humans and animals with serious (often fatal) infections (93, 584, 698, 699). The other pathogenic Nocardia species appear to be taxonomically more homogeneous and include N. brasiliensis, N. otitidiscaviarum (N. caviae), and N. transvalensis (275, 420). There is even one Nocardia species that infects plants: N. vaccinii, which causes galls on blueberry plants (420).

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Peritonsillar abscess caused by Nocardia asteroides

Cited by 10 publications

References 6 publications

Site-specific growth of Nocardia asteroides in the murine brain

Site-specific growth of Nocardia asteroides in the murine brain

Nocardialung abscess in an immunocompetent adolescent

Nocardia species: host-parasite relationships.

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