Peritonitis due to <i>Aspergillus terreus</i> in a patient undergoing continuous ambulatory peritoneal dialysis

Verghese, Susan T.; Ravichandran, Palani; Thirunavakarasu, Natarajan; Chellamma, Thabitha; Pathipata, Padmaja

doi:10.1111/j.1439-0507.2007.01465.x

Cited by 9 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, A. terreus has been reported as a human pathogen and can cause superficial, cutaneous, and subcutaneous mycoses that affect the nail bed (28), outer ear canal (60), and skin (16). More recently, A. terreus has been associated with postoperative osteomyelitis (43), endophthalmitis (22), and peritonitis (63), and the species has been identified as an emerging opportunistic pathogen in immunocompromised populations (3,4). Knowledge of A. terreus pathogenesis is limited; however, the species is thermotolerant and produces aleurioconidia that may provide an advantage in dissemination (48).…”

mentioning

confidence: 99%

Monoclonal Antibodies to Hyphal Exoantigens Derived from the Opportunistic Pathogen Aspergillus terreus

Nayak

Green

Janotka

et al. 2011

Clin. Vaccine Immunol.

View full text Add to dashboard Cite

Aspergillus terreus has been difficult to identify in cases of aspergillosis, and clinical identification has been restricted to the broad identification of aspergillosis lesions in affected organs or the detection of fungal carbohydrates. As a result, there is a clinical need to identify species-specific biomarkers that can be used to detect invasive A. terreus disease. Monoclonal antibodies (MAbs) were developed to a partially purified preparation of cytolytic hyphal exoantigens (HEA) derived from A. terreus culture supernatant (CSN). Twentythree IgG1 isotype murine MAbs were developed and tested for cross-reactivity against hyphal extracts of 54 fungal species. Sixteen MAbs were shown to be specific for A. terreus. HEA were detected in conidia, hyphae, and in CSN of A. terreus. HEA were expressed in high levels in the hyphae during early stages of A. terreus growth at 37°C, whereas at room temperature the expression of HEA peaked by days 4 to 5. Expression kinetics of HEA in CSN showed a lag, with peak levels at later time points at room temperature and 37°C than in hyphal extracts. Serum spiking experiments demonstrated that human serum components do not inhibit detection of the HEA epitopes by MAb enzyme-linked immunosorbent assay (ELISA). Immunoprecipitation and proteomic analysis demonstrated that MAbs 13E11 and 12C4 immunoprecipitated a putative uncharacterized leucine aminopeptidase (Q0CAZ7), while MAb 19B2 recognized a putative dipeptidyl-peptidase V (DPP5). Studies using confocal laser scanning microscopy showed that the uncharacterized leucine aminopeptidase mostly localized to extracellular matrix structures while dipeptidyl-peptidase V was mostly confined to the cytoplasm.

show abstract

mentioning

confidence: 99%

Monoclonal Antibodies to Hyphal Exoantigens Derived from the Opportunistic Pathogen Aspergillus terreus

Nayak

Green

Janotka

et al. 2011

Clin. Vaccine Immunol.

View full text Add to dashboard Cite

show abstract

“…In 2002, Matsumoto, et al reviewed 20 Aspergillus spp peritonitis cases that have been published between 1968-2002. In our literature review covering the period from 2002 to 2013, we were able to find the records of 13 published cases of aspergillus peritonitis, including our two cases presented here (Table 1) [18][19][20][21]. Combined outcome results of two series reveal that, out of 33 cases presented since 1968, 11(33%) died and 13(39%) had to be transferred to hemodialysis.…”

Section: Discussionmentioning

confidence: 98%

Aspergillus Peritonitis in Chronic Peritoneal Dialysis Patients: Review of the Literature and Report of Two Cases

Yılmaz¹,

Uslu²,

Bora³

et al. 2015

BANTAO Journal

View full text Add to dashboard Cite

Although gram positive bacteriae are the most common causative microorganisms of chronic peritoneal dialysis (CPD) peritonitis, fungi are responsible for 1-15% of all cases. On the other hand, fungal peritonitis episodes may potentially cause serious consequences such as resistance to treatment, extended hospital stay and also a higher probability of death. Fungal peritonitis due to Aspergillus spp is relatively uncommon, but its mortality rate and severity is known to be even higher. It was our aim to conduct a review of the medical literature regarding the treatment and clinical outcome of Aspergillus related CPD peritonitis and to present two cases with Aspergillus related CPD events. Our current knowledge and the outcome of our two cases suggest that, despite the use of recommended therapeutic measures, Aspergillus induced fungal peritonitis in CPD patients may still be fatal. Therefore, there is a need for development of more efficient therapeutic approaches including the type, dose and route of antifungal therapy.

show abstract

“…13 Filamentous fungi less frequently cause FP; however, different types of filamentous fungi have been reported to cause peritonitis, including Aspergillus, Paecilomyces, Penicillium, and Acremonium spp. 5,7,14 Although Aspergillus spp. rarely cause FP (2-5% of cases), it has a high morbidity and mortality rate and its diagnosis and treatment is challenging.…”

Section: Discussionmentioning

confidence: 99%

“…have been reported worldwide; however, there is a paucity of data from Pakistan. [5][6][7][8] Here, a case of congenital nephrotic syndrome (CNS) is reported in a patient who progressed to CKD-5 when she was 8 years old, which was managed by CAPD and other supportive therapies. She developed recurrent episodes of BP and ultimately FP and succumbed to death despite use of aggressive systemic and intraperitoneal (IP) antibiotics and antifungal agents, removal of the PD catheter, switching to HD, and receiving intensive ventilator care.…”

Section: Introductionmentioning

confidence: 99%

Aspergillus terreus Peritonitis in a Child on Continuous Ambulatory Peritoneal Dialysis: A Case Report from Pakistan

Moin

Moorani

Qureshi

2022

EMJ Microbiol Infect Dis

View full text Add to dashboard Cite

Background: Aspergillus peritonitis is a rare, potentially fatal complication of continuous ambulatory peritoneal dialysis (CAPD). Several cases of fungal peritonitis (FP) caused by Aspergillus species have been reported worldwide; however, there is a paucity of data from Pakistan. Here, a case of congenital nephrotic syndrome is reported in a patient who progressed to Stage 5 chronic kidney disease when she was 8 years old, which was managed by CAPD and other supportive therapies. The patient developed FP and later succumbed to death despite appropriate management. Early diagnosis and careful interpretation of culture results are, therefore, important for the treatment of these patients. Case presentation: The patient outlined in this case report had congenital nephrotic syndrome, Stage 5 chronic kidney disease, and was on CAPD. She presented with peritonitis. Initially, broad spectrum antibiotics were started, and peritoneal samples did not yield any growth. Later, consecutive peritoneal samples taken from the patient grew Aspergillus terreus, with septate hyphae seen on a direct smear from the sample. Voriconazole was started immediately, and the patients’ catheter was removed. However, the patient’s condition deteriorated and, after prolonged intensive care and high ventilator support, the patient expired. Conclusion: A. terreus is an uncommon and deadly pathogen that does not respond to the commonly used antifungal treatments such as amphotericin B. The treatment of CAPD-related FP requires early diagnosis and the use of newer drugs such as voriconazole or caspofungin.

show abstract

Peritonitis due to Aspergillus terreus in a patient undergoing continuous ambulatory peritoneal dialysis

Abstract: Aspergillus peritonitis is a rare, potentially fatal complication of continuous ambulatory peritoneal dialysis (CAPD). We report a case of CAPD peritonitis caused by Aspergillus terreus in a 55-year-old female patient.

Cited by 9 publications

References 0 publications

Monoclonal Antibodies to Hyphal Exoantigens Derived from the Opportunistic Pathogen Aspergillus terreus

Monoclonal Antibodies to Hyphal Exoantigens Derived from the Opportunistic Pathogen Aspergillus terreus

Aspergillus Peritonitis in Chronic Peritoneal Dialysis Patients: Review of the Literature and Report of Two Cases

Aspergillus terreus Peritonitis in a Child on Continuous Ambulatory Peritoneal Dialysis: A Case Report from Pakistan

Contact Info

Product

Resources

About