Peritonectomy and hyperthermic antiblastic perfusion in the treatment of peritoneal carcinomatosis

Cavaliere, F.; Filippo, F. Di; Botti, Claudio; Cosimelli, Maurizio; Giannarelli, Diana; Aloe, L; Arcuri, Edoardo; Aromatario, C; Consolo, S; Callopoli, A.; Laurenzi, L; Tedesco, Manfredo; Angelo, P. Di; Giunta, Salvatore; Cavaliere, R.

doi:10.1053/ejso.1999.0927

Cited by 41 publications

(24 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These observations are consistent with the clinical finding that in as many as 30% of patients with colorectal adenocarcinoma disease progression eventually leads to synchronous (8-10%) or metachronous colorectal peritoneal carcinomatosis (25%) [2,3]. The concept has, therefore, emerged that since some peritoneal carcinomatosis, including those of colorectal origin, are a form of locoregional cancer dissemination, they should be treated with a locoregional approach [4].…”

Section: Introductionsupporting

confidence: 82%

See 1 more Smart Citation

Prognostic factors and oncologic outcome in 146 patients with colorectal peritoneal carcinomatosis treated with cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy: Italian multicenter study S.I.T.I.L.O.

Cavaliere¹,

Simone²,

Virzì³

et al. 2011

European Journal of Surgical Oncology (EJSO)

124

View full text Add to dashboard Cite

Section: Introductionsupporting

confidence: 82%

“…This combined treatment approach is nevertheless costly, time-consuming, and carries high morbidity and mortality rates that come within acceptable ranges only after a lengthy learning curve [8][9].…”

Section: Introductionmentioning

confidence: 99%

Prognostic factors and oncologic outcome in 146 patients with colorectal peritoneal carcinomatosis treated with cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy: Italian multicenter study S.I.T.I.L.O.

Cavaliere¹,

Simone²,

Virzì³

et al. 2011

European Journal of Surgical Oncology (EJSO)

124

View full text Add to dashboard Cite

“…chemotherapy cannot be properly assessed in the present study and further studies are needed to clarify a possible contribution of locoregional chemotherapy to the treatment effect. A possible benefit of a repeated regional treatment has been suggested since the end of 1960s (Long et al, 1969) and several reports have been published since then Stephens et al, 1999;Cavaliere et al, 2000;Elias et al, 2001). One of the major problems is the nonuniform distribution of the chemotherapy to tumour deposits within the abdominal cavity.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, recent clinical studies have shown promising results (Beaujard et al, 2000;Cavaliere et al, 2000). However, there is a lack of consensus about the optimal target temperature and a finding of increased morbidity and mortality when a cytoreduction procedure has been followed by hyperthermic i.p.…”

Section: Discussionmentioning

confidence: 99%

Improved survival in patients with peritoneal metastases from colorectal cancer: a preliminary study

et al. 2004

View full text Add to dashboard Cite

Patients with peritoneal or local metastases from colorectal cancer have a poor prognosis. However, aggressive treatments by debulking surgery and infusional intraperitoneal (i.p.) chemotherapy have been tried and appear to benefit selected patients. We assayed the effects of debulking surgery and i.p. chemotherapy with respect to survival and compared the results with matched control patients treated by intravenous (i.v.) chemotherapy. In all, 18 patients with peritoneal and/or local metastases from colorectal adenocarcinoma underwent debulking surgery followed by 5-fluorouracil (5-FU) 550 mg m À2 day À1 i.p. and leucovorin (LV) 60 mg m À2 day À1 i.v. The chemotherapy was started the day after surgery and was given daily for 6 days and repeated monthly for totally eight courses. The control patients, matched for age, gender, performance status and metastatic site, were randomly selected from controlled clinical chemotherapy trials and treated with i.v. 5-FU þ LV or i.v. methotrexate þ 5-FU þ LV. There was no treatment-related mortality. The median survival among i.p. patients was 32 months compared to 14 months in the control group. In all, 11 patients who underwent macroscopically radical surgery had a longer survival than those who were not radically operated (P ¼ 0.02). These results indicate that patients with peritoneal metastases and/or locally advanced cancers but without distant metastases may benefit from cytoreductive surgery combined with i.p. chemotherapy.

show abstract

“…Cavaliere et al [8] In this study conducted in Rome, the authors analyzed their experience with 37 patients with peritoneal surface malignancies of different etiologies. They evaluated the effect of the learning curve in regards to morbidity and mortality.…”

Section: Journal Of Surgical Oncologymentioning

confidence: 99%

Learning curve in cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

Moradi

Esquivel

2009

Journal of Surgical Oncology

View full text Add to dashboard Cite

Cytoreductive surgery and Hyperthermic Intraperitoneal Chemotherapy have achieved good long-term results in patients with complete surgical eradication of their peritoneal dissemination but at the expense of significant perioperative morbidity and mortality. The high complication rate has been attributed to the steep learning curve associated with this procedure. We report on the current literature regarding the learning curve for this procedure and the key components that determine the success in learning this new skill.

show abstract

Peritonectomy and hyperthermic antiblastic perfusion in the treatment of peritoneal carcinomatosis

Cited by 41 publications

References 12 publications

Prognostic factors and oncologic outcome in 146 patients with colorectal peritoneal carcinomatosis treated with cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy: Italian multicenter study S.I.T.I.L.O.

Prognostic factors and oncologic outcome in 146 patients with colorectal peritoneal carcinomatosis treated with cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy: Italian multicenter study S.I.T.I.L.O.

Improved survival in patients with peritoneal metastases from colorectal cancer: a preliminary study

Learning curve in cytoreductive surgery and hyperthermic intraperitoneal chemotherapy

Contact Info

Product

Resources

About