Peritoneal pharmacokinetics of cefepime in laparotomy patients with inflammatory bowel disease, and dosage considerations for surgical intra-abdominal infections based on pharmacodynamic assessment

Higuchi, Kazuko; Ikawa, Kazuro; Ikeda, Kayo; Ohge, Hiroki; Sueda, Taijiro; Morikawa, Norifumi

doi:10.1007/s10156-007-0584-x

Cited by 5 publications

(8 citation statements)

References 19 publications

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“…Further, no samples were obtained from peritoneal fluid, which would have been indicative of antibiotic effects at the site of infection. Other studies [14,[31][32][33] have been performed in patients after abdominal surgery. In these studies, the AUC ratio of peritoneal exudates:plasma was *90% for cefepime, cefozopran, and cefotiam (cefozopran and cefotiam are available only in certain countries; e.g., China and Japan).…”

Section: Cephalosporinsmentioning

confidence: 99%

“…For cefepime, 3-h infusions of 1 g q 8 h and 2 g q 12 h achieved a T > MIC above 85% for an MIC of 4 mcg/mL in peritoneal fluid [31]. The MIC data were derived from susceptibility surveillances of surgical infections from four major types of bacteria that cause post-operative IAIs: Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Enterobacter cloacae.…”

Section: Cephalosporinsmentioning

confidence: 99%

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Pharmacokinetics of Beta-Lactam Antibiotics in Patients with Intra-Abdominal Disease: A Structured Review

Adnan

Paterson

Lipman

et al. 2012

Surgical Infections

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Most of the available data demonstrate that drug volume of distribution can be increased significantly in the presence of intra-abdominal disease. Drug clearance is likely to vary in line with renal or hepatic function. Thus, dose optimization is important to prevent development of antibiotic resistance or therapeutic failure. However, further research is necessary to determine the clinical outcome of individualized dosing on the basis of pharmacokinetic/pharmacodynamic studies.

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Section: Cephalosporinsmentioning

confidence: 99%

Section: Cephalosporinsmentioning

confidence: 99%

Pharmacokinetics of Beta-Lactam Antibiotics in Patients with Intra-Abdominal Disease: A Structured Review

Adnan

Paterson

Lipman

et al. 2012

Surgical Infections

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“…Specifically, CL was four times greater for imipenem-cilastin [89], three times higher for cefepime [107] and two times greater for doripenem [90]. The increased CL associated with post-operative state suggests the need for more frequent dosing of beta-lactam antibiotics.…”

Section: Summary Of Pk Datamentioning

confidence: 95%

“…Further, no samples were obtained from peritoneal fluid, which would have been indicative of antibiotic effects at the site of infection. Other studies [71,100,101,107] have been performed in patients after abdominal surgery. In these studies, the AUC ratio of peritoneal exudate: plasma was ~90% for each of cefepime, cefozopran and cefotiam respectively (cefozopran and cefotiam are only available at certain countries, e.g.…”

Section: Cephalosporinsmentioning

confidence: 99%

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Improving antimicrobial use in critically ill patients

Adnan¹

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Development and validation of an LC–ESI–QTOF–MS method to measure cefepime in the plasma and peritoneal fluid of rats using microdialysis: Application in a pilot pharmacokinetic study

Anjos

Possa

Fonseca

et al. 2022

Biomedical Chromatography

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Cefepime (CEF) is a cephalosporin and can be administered in secondary peritonitis together with metronidazole to treat sepsis. This study aimed to develop and validate an LC-ESI-QTOF-MS method for the quantification of cefepime in the plasma and peritoneal microdialysate of healthy Wistar rats. Chromatographic separation was performed using a CLC-ODS C 18 column (250 Â 4.6 mm), a C 18 pre-column (4 mm, 5 μm) and isocratic elution. Gallic acid was used as the internal standard. The mobile phase consisted of (A) ultrapure water (pH adjusted to 3.5) and (B) acetonitrile (80:20, v/v) at 0.8 ml/min. Quantification was performed using a mass spectrometer with electrospray ionization in positive mode to monitor ions with m/z 481.1322 (CEF) and m/z 171.0288 (IS). The method was validated for selectivity, precision, accuracy, linearity, stability, lower limit of quantification, carryover, recovery and matrix effect. Calibration was done in the ranges 1-40 and 1-100 μg/ml for the peritoneal microdialysate and plasma, respectively. Plasma extraction recovery ranged from 93.9 to 99.9%. The technique was validated and successfully applied in a pilot pharmacokinetic study for estimating the free concentration of CEF in the peritoneal microdialysate of rats for the first time.

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Peritoneal pharmacokinetics of cefepime in laparotomy patients with inflammatory bowel disease, and dosage considerations for surgical intra-abdominal infections based on pharmacodynamic assessment

Cited by 5 publications

References 19 publications

Pharmacokinetics of Beta-Lactam Antibiotics in Patients with Intra-Abdominal Disease: A Structured Review

Pharmacokinetics of Beta-Lactam Antibiotics in Patients with Intra-Abdominal Disease: A Structured Review

Improving antimicrobial use in critically ill patients

Development and validation of an LC–ESI–QTOF–MS method to measure cefepime in the plasma and peritoneal fluid of rats using microdialysis: Application in a pilot pharmacokinetic study

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