Peritoneal macrophage response: an in vivo model for the study of synthetic materials

Freyria, Anne‐Marie; Chignier, E.; Guidollet, J; Louisot, Pierre

doi:10.1016/0142-9612(91)90187-f

Cited by 41 publications

(29 citation statements)

References 18 publications

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“…We and others have shown that the peritoneal cavity is a good implantation site for studying biomaterial:tissue interactions because the reactions elicited by implanted materials are clearly defined with minimal participation of the coagulation system. 31,41,42,[50][51][52][53] After explantation, the number of implant-associated phagocytes (neutrophils and M) and the amounts of implant-associated hydroxyproline were measured to reflect the extent of biomaterial-mediated acute inflammatory and chronic fibrotic responses.…”

Section: Acute Inflammatory Responses To Implanted Test Surfacesmentioning

confidence: 99%

Fibrinogen adsorption and host tissue responses to plasma functionalized surfaces

Tang

Timmons

1998

J. Biomed. Mater. Res.

110

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The physical and chemical characteristics of material surfaces are thought to play important roles in biomaterial-mediated tissue responses. To understand the importance of discrete biomaterial chemical characteristics in modifying host tissue responses, we constructed surfaces bearing different functional groups using radio frequency glow discharge plasma polymerization. Surfaces evaluated included those having high concentrations of -OH, -NH2, -CF3, and siloxyl groups. These surfaces and polyethylene terephthalate controls were used to assess the importance of particular physicochemical characteristics in surface:protein:cell interactions both in vitro and in vivo. The results obtained show that surface functionalities do significantly affect both the adsorption and "denaturation" of adsorbed fibrinogen (which is an important mediator of inflammatory responses to biomaterial implants). In addition, these surfaces provoke different degrees of acute inflammatory responses. Interestingly, the amounts of "denatured" fibrinogen that spontaneously accumulate on the individual surfaces correlate closely with the extent of biomaterial-mediated inflammation. These results suggest that surfaces that tend to "irreversibly" bind fibrinogen prompt greater acute inflammatory responses. Unexpectedly, all test surfaces except those bearing a siloxyl group engender relatively similar biomaterial-mediated fibrotic responses. Thus surface functionalities alone may not be sufficient to affect subsequent fibrotic responses.

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Section: Acute Inflammatory Responses To Implanted Test Surfacesmentioning

confidence: 99%

Fibrinogen adsorption and host tissue responses to plasma functionalized surfaces

Tang

Timmons

1998

J. Biomed. Mater. Res.

110

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“…Also, it is desirable and of interest to use dielectric-coated metallic nanoparticles with varying shell thickness to form a dielectric constant gradient [56]. In nature, there are also many graded materials, such as liquid crystal droplets [108] and biological cells [24], because of the inhomogeneous compartment inside them.…”

Section: Composite Media Of Graded Spherical Particlesmentioning

confidence: 99%

“…For example, recently we studied graded composites, which provided an extra degree of freedom for controlling the nonlinear optical properties of these materials by choosing appropriate gradation profiles [19][20][21][22][23]. In fact, there exist in Nature abundant graded materials, such as biological cells [24] and liquid crystal droplets [25]. Furthermore, many artificially-graded-index optical metamaterials and elements have been fabricated nowadays [26].…”

Section: Introductionmentioning

confidence: 99%

Enhanced nonlinear optical responses of materials: Composite effects

2006

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We review recent theoretical progress in understanding physical processes of composite effects on enhanced third-order nonlinear optical responses of various kinds of the recently-proposed nonlinear optical materials, namely, colloidal nanocrystals with inhomogeneous metallodielectric particles or a graded-index host, metallic films with inhomogeneous microstructures adjusted by ion doping or temperature gradient, composites with compositional gradation or graded particles, and magneto-controlled ferrofluidbased nonlinear optical materials.

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“…As far as one decade ago, Freyria et al observed a graded cell response when they experimentally study cell-implant interactions [19]. Recently, motivated by positional information of protein molecules, Honda and Mochizuki performed computer simulations of cell pattern formation showing that graded cells can be generated by cell behavior involving differences in intercellular repulsion [20].…”

Section: Introductionmentioning

confidence: 99%

Electrorotation in graded colloidal suspensions

Huang

et al. 2003

Phys. Rev. E

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Biological cells can be treated as composites of graded material inclusions. In addition to biomaterials, graded composites are important in more traditional materials science. In this article, we investigate the electrorotation (ER) spectrum of a graded colloidal suspension in an attempt to discuss its dielectric properties. For that, we use the recently obtained differential effective dipole approximation (DEDA) and generalize it for non-spherical particles. We find that variations in the conductivity profile may make the characteristic frequency red-shifted and have also an effect on the rotation peak. On the other hand, variations in the dielectric profile may enhance the rotation peak, but do not have any significant effect on the characteristic frequency. In the end, we apply our theory to fit experimental data obtained for yeast cells and find good agreement.

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Peritoneal macrophage response: an in vivo model for the study of synthetic materials

Cited by 41 publications

References 18 publications

Fibrinogen adsorption and host tissue responses to plasma functionalized surfaces

Fibrinogen adsorption and host tissue responses to plasma functionalized surfaces

Enhanced nonlinear optical responses of materials: Composite effects

Electrorotation in graded colloidal suspensions

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