Peritoneal M2 macrophage-derived extracellular vesicles as natural multitarget nanotherapeutics to attenuate cytokine storms after severe infections

Wang, Yizhuo; Liu, Shuyun; Li, Lan; Li, Ling; Zhou, Xueli; Wan, Mei-Hua; Lou, Ping; Zhao, Meng; Lv, Ke; Yuan, Yujia; Chen, Younan; Lu, Yanrong; Cheng, Jun; Liu, Jingping

doi:10.1016/j.jconrel.2022.06.063

Cited by 31 publications

(31 citation statements)

References 52 publications

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“…Interestingly, a high number of MØs, neutrophils, or a higher ratio of MØs/DCs can be associated with severe and recurrent episodes of peritonitis [ 51 ]. Moreover, peritoneal resident M2 MØs have been demonstrated to have an active role in attenuating the cytokine storm in severe acute infections [ 56 ].…”

Section: Cellular and Molecular Mechanisms Implicated In The Damage O...mentioning

confidence: 99%

“…M2 MØs has been previously discussed for their immunomodulatory/anti-inflammatory activity during peritoneum infections. Accordingly, treatment with extracellular vesicles (EVs) generated in response to SARS-CoV-2 infection reduced the expression of inflammatory cytokines, such as TNF-α and IL-6, released in vitro and in vivo, attenuating oxidative stress and multiple organs (lung, liver, spleen, and kidney) damage in endotoxin-induced cytokine storms [ 56 ]. Moreover, M2 peritoneal MØs were also demonstrated to release high levels of ACE2 in EVs and this could represent a decoy strategy to prevent SARS-CoV-2 infection [ 56 ].…”

Section: Covid-19 In Ckd Patients Under Krt and In Mesotheliummentioning

confidence: 99%

“…Accordingly, treatment with extracellular vesicles (EVs) generated in response to SARS-CoV-2 infection reduced the expression of inflammatory cytokines, such as TNF-α and IL-6, released in vitro and in vivo, attenuating oxidative stress and multiple organs (lung, liver, spleen, and kidney) damage in endotoxin-induced cytokine storms [ 56 ]. Moreover, M2 peritoneal MØs were also demonstrated to release high levels of ACE2 in EVs and this could represent a decoy strategy to prevent SARS-CoV-2 infection [ 56 ]. Similarly to MØs, pleura MCs have been demonstrated to produce anti-inflammatory cytokines in vitro in response to SARS-CoV-2 viral infection [ 239 ].…”

Section: Covid-19 In Ckd Patients Under Krt and In Mesotheliummentioning

confidence: 99%

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Novel Aspects of the Immune Response Involved in the Peritoneal Damage in Chronic Kidney Disease Patients under Dialysis

Trionfetti

Marchant

González-Mateo

et al. 2023

IJMS

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Chronic kidney disease (CKD) incidence is growing worldwide, with a significant percentage of CKD patients reaching end-stage renal disease (ESRD) and requiring kidney replacement therapies (KRT). Peritoneal dialysis (PD) is a convenient KRT presenting benefices as home therapy. In PD patients, the peritoneum is chronically exposed to PD fluids containing supraphysiologic concentrations of glucose or other osmotic agents, leading to the activation of cellular and molecular processes of damage, including inflammation and fibrosis. Importantly, peritonitis episodes enhance peritoneum inflammation status and accelerate peritoneal injury. Here, we review the role of immune cells in the damage of the peritoneal membrane (PM) by repeated exposure to PD fluids during KRT as well as by bacterial or viral infections. We also discuss the anti-inflammatory properties of current clinical treatments of CKD patients in KRT and their potential effect on preserving PM integrity. Finally, given the current importance of coronavirus disease 2019 (COVID-19) disease, we also analyze here the implications of this disease in CKD and KRT.

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Section: Cellular and Molecular Mechanisms Implicated In The Damage O...mentioning

confidence: 99%

Section: Covid-19 In Ckd Patients Under Krt and In Mesotheliummentioning

confidence: 99%

Section: Covid-19 In Ckd Patients Under Krt and In Mesotheliummentioning

confidence: 99%

See 1 more Smart Citation

Novel Aspects of the Immune Response Involved in the Peritoneal Damage in Chronic Kidney Disease Patients under Dialysis

Trionfetti

Marchant

González-Mateo

et al. 2023

IJMS

View full text Add to dashboard Cite

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“…Furthermore, evACE2 can effectively block the original coronavirus strain and mutant strains such as Alpha, Beta, and Delta. In addition, human peritoneal M2 macrophage-derived extracellular vesicles (M2-EVs) expressed ACE2 and thus could also serve as nanodecoys to prevent SARS-CoV-2 pseudovirus infection in vitro [ 28 ].…”

Section: Nanotechnology Solutions To the Challenge Of Sars-cov-2mentioning

confidence: 99%

“…M2 macrophages mainly play roles in immune regulation and tissue repair. Recent studies have found that M2-EVs can be used as a multi-targeted nanomedicine for treating cytokine storms caused by pathogen infections [ 28 ].…”

Section: Nanotechnology Solutions To the Challenge Of Sars-cov-2mentioning

confidence: 99%

Biomimetic Nanotechnology for SARS-CoV-2 Treatment

Liu

et al. 2023

Viruses

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More than 600 million people worldwide have been infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), resulting in the pandemic of coronavirus disease 2019 (COVID-19). In particular, new waves of COVID-19 caused by emerging SARS-CoV-2 variants pose new health risks to the global population. Nanotechnology has developed excellent solutions to combat the virus pandemic, such as ACE2-based nanodecoys, nanobodies, nanovaccines, and drug nanocarriers. Lessons learned and strategies developed during this battle against SARS-CoV-2 variants may also serve as inspiration for developing nanotechnology-based strategies to combat other global infectious diseases and their variants in the future.

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Cell‐Based Biomaterials for Coronavirus Disease 2019 Prevention and Therapy

Wang

Xie

et al. 2023

Adv Healthcare Materials

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Coronavirus disease 2019 (COVID-19) continues to threaten human health, economic development, and national security. Although many vaccines and drugs have been explored to fight against the major pandemic, their efficacy and safety still need to be improved. Cell-based biomaterials, especially living cells, extracellular vesicles, and cell membranes, offer great potential in preventing and treating COVID-19 owing to their versatility and unique biological functions. In this review, the characteristics and functions of cell-based biomaterials and their biological applications in COVID-19 prevention and therapy are described. First the pathological features of COVID-19 are summarized, providing enlightenment on how to fight against COVID-19. Next, the classification, organization structure, characteristics, and functions of cell-based biomaterials are focused on. Finally, the progress of cell-based biomaterials in overcoming COVID-19 in different aspects, including the prevention of viral infection, inhibition of viral proliferation, anti-inflammation, tissue repair, and alleviation of lymphopenia are comprehensively described. At the end of this review, a look forward to the challenges of this aspect is presented.

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Peritoneal M2 macrophage-derived extracellular vesicles as natural multitarget nanotherapeutics to attenuate cytokine storms after severe infections

Cited by 31 publications

References 52 publications

Novel Aspects of the Immune Response Involved in the Peritoneal Damage in Chronic Kidney Disease Patients under Dialysis

Novel Aspects of the Immune Response Involved in the Peritoneal Damage in Chronic Kidney Disease Patients under Dialysis

Biomimetic Nanotechnology for SARS-CoV-2 Treatment

Cell‐Based Biomaterials for Coronavirus Disease 2019 Prevention and Therapy

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