Peritoneal fluid cytology and prognosis in patients with endometrial carcinoma

Hirai, Yasuo; Fujimoto, Ichiro; Yamauchi, Kazuma; Hasumi, K; Masubuchi, K; Sano, Yoshiyuki

doi:10.1016/0020-7292(89)90237-3

Cited by 13 publications

(4 citation statements)

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“…The efficacy of these modalities for treating positive cytology in the absence of other evidence of extrauterine disease is not universally accepted (McLellan et al, 1989;Lurain, 1992). On the other hand, investigators who did not find that malignant peritoneal cytology is a significant prognostic factor found no benefit of adjuvant therapy in patients with positive cytology in the absence of other adverse prognostic factors (Yazigi et al, 1983; Peritoneal cytology in endometrial carcinoma T Kasamatsu et al Hernandez et al, 1985;Konski et al, 1988;Hirai et al, 1989;Lurain et al, 1989;Grimshaw et al, 1990;Kadar et al, 1992;Kennedy et al, 1993;Ayhan et al, 1994;Ebina et al, 1997;Yalman et al, 2000). This discrepancy is probably because of the following: (1) the reported incidence of positive cytology was approximately 10% and the number of subjects was small; (2) the difference between the surgical stage and the clinical stage was not always distinguished; (3) various modalities of preoperative and/or postoperative therapies were used; (4) in the statistical analysis, multivariate analysis was not always employed; (5) the objectivity of the cytopathologic diagnosis was not always guaranteed; and (6) a prospective study has not been performed.…”

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confidence: 99%

Prognostic significance of positive peritoneal cytology in endometrial carcinoma confined to the uterus

et al. 2003

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A retrospective analysis was performed to evaluate the prognostic significance of peritoneal cytology in patients with endometrial carcinoma limited to the uterus. A total of 280 patients with surgically staged endometrial carcinoma that was histologically confined to the uterus were examined clinicopathologically. The median length of follow-up was 62 (range, 12 -135) months. All patients underwent hysterectomy and salpingo-oophorectomy with selective lymphadenectomy, and only three patients received adjuvant postoperative therapy. No preoperative adjuvant therapy was employed. In all, 48 patients (17%) had positive peritoneal cytology. The 5-year survival rate among patients with positive or negative peritoneal cytology was 91 or 95%, respectively, showing no significant difference (log-rank, P ¼ 0.42). The disease-free survival rate at 36 months was 90% among patients with positive cytology, compared with that of 94% among patients with negative cytology, and the difference was not significant (log-rank, P ¼ 0.52). Multivariate proportional hazards model revealed only histologic grade to be an independent prognostic factor of survival (P ¼ 0.0003, 95% CI 3.02 -40.27) among the factors analysed (age, peritoneal cytology, and depth of myometrial invasion). Multivariate analysis revealed that histologic grade (P ¼ 0.02, 95% CI 1.21 -9.92) was also the only independent prognostic factor of disease-free survival. We concluded that the presence of positive peritoneal cytology is not an independent prognostic factor in patients with endometrial carcinoma confined to the uterus, and adjuvant therapy does not appear to be beneficial in these patients.

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Section: Discussionmentioning

confidence: 99%

Prognostic significance of positive peritoneal cytology in endometrial carcinoma confined to the uterus

et al. 2003

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“…endometrioid adenocarcinoma confined to the uterus. Before incorporating peritoneal cytology into the new staging system in 1988, the incidence of positive cytology in stage I endometrioid adenocarcinoma was reported to range from 15 to 35% [3,12] while it dropped to 5 to 10% in the literature of the last 15 years [4,8]. In our study, we found 8.7% peritoneal cytology positivity in patients with.…”

Section: Discussionmentioning

confidence: 72%

Positive peritoneal cytology and its prognostic value in endometrioid adenocancer confined to the uterus

Metindir

Dilek

2008

Oncologie

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Background: The aim of this study was to evaluate the prognostic significance of peritoneal cytology in patients with endometrioid adenocarcinoma limited to the uterus.Methods: A retrospective study was performed on 46 patients with surgically staged endometrioid adenocarcinoma that was histologically confined to the uterus. Patients who had negative nodes, disease localized to the uterus and endometrioid subtype were included. The Chi-square ( 2 ) test was used for statistical analysis. Disease free survival rates calculated by the Kaplan-Meier method, and log-rank test was used for comparison.Stepwise Cox proportional hazard model was used to assess the independent prognostic and predictive factors affecting disease free survival. Results:The median duration of the follow-up period was 36 months (1-104 months). Peritoneal cytology was positive in 4 patients (8.7%). The disease-free survival rate at 36 months was 50% among patients with positive cytology, compared with that of 92.9% among patients with negative cytology, and the difference was significant (log-rank, P = 0.036). Multivariate analysis revealed that peritoneal cytology was independent prognostic factor (P = 0.016; OR: 9.0; 95%CI: 1.497-54.179) of disease-free survival in patients with endometrial carcinoma confined to the uterus. Conclusion:We concluded that the presence of positive peritoneal cytology is an independent prognostic factor in patients with endometrial carcinoma confined to the uterus.

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“…O carreamento de células neoplásicas para a cavidade peritonial é uma possibilidade, e a literatura é controversa quanto ao prognóstico destas pacientes, com relatos mostrando não haver diferenças nas taxas de recorrência e sobrevivência nas pacientes que tiveram ou não células malignas detectadas na cavidade peritonial 16,17 , e outros mostrando poder haver piora no prognóstico 18,19 . A injeção lenta e sob baixa pressão deve ser utilizada para prevenir o extravasamento do contraste, e nos casos suspeitos de neoplasia é recomendado o uso de água destilada para causar lise osmótica das células desgarradas com o procedimento, evitando-se assim a possibilidade de disseminação da doença 12,20 .…”

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A Histerossonografia na Avaliação da Cavidade Uterina em Pacientes Menopausadas

Júnior

Melo

Neto

2002

Rev. Bras. Ginecol. Obstet.

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Muitas delas serão submetidas à ultra-sonografia endovaginal como rotina ou para avaliação de sangramento uterino anormal, e apresentarão alterações na cavidade uterina. Em 60% das mulheres com sangramento pós-menopausa, nenhuma causa orgânica é encontrada. Karlsson et al. 2 , em estudo multicêntrico randomizado com 1168 pacientes menopausadas com sangramento vaginal, não tiveram nenhum caso de câncer em casos com espessura endometrial menor ou igual a

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Peritoneal fluid cytology and prognosis in patients with endometrial carcinoma

Cited by 13 publications

References 0 publications

Prognostic significance of positive peritoneal cytology in endometrial carcinoma confined to the uterus

Prognostic significance of positive peritoneal cytology in endometrial carcinoma confined to the uterus

Positive peritoneal cytology and its prognostic value in endometrioid adenocancer confined to the uterus

A Histerossonografia na Avaliação da Cavidade Uterina em Pacientes Menopausadas

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