Peritoneal fluid cytokine and eicosanoid levels and their relation to the incidence of peritoneal adhesion

Abstract

Although the effect of length of time since the adhesions were formed is not known, the results indicate that peritoneal fluid content of these cytokines and eicosanoids, with the exception of IFN-gamma and TGF-beta 1, does not correlate with the presence of peritoneal adhesions.

Effects of interferon-γ reverse hypoxia-stimulated extracellular matrix expression in human peritoneal and adhesion fibroblasts

“…Expression of IFN-␥ was almost diminished with the simultaneous increase in IL-10 expression in adhesion fibroblasts under hypoxic conditions (11). This is consistent with previous findings that showed adhesion tissues to contain a significantly lower amount of IFN-␥ and a higher amount of IL-10 as compared with peritoneal tissue (27). This finding is in agreement with the well-known fact that IL-10 inhibits IFN-␥ expression in most cell systems.…”

Abdominal Adhesion Prevention: Still a Sticky Subject

“…Targets for the control of these processes include chemokines [19,20] and matrix metalloproteinases [21]. Vascular endothelial growth factor has also been implicated in having an early role in adhesion initiation [22].…”

Peritoneal cytokines and adhesion formation in endometriosis: an inverse association with vascular endothelial growth factor concentration

“…It has become accepted that the development of pelvic adhesions involves inflammatory responses, abrogated fibrinolysis, and the protease/protease inhibitor system, as well as angiogenesis (10)(11)(12)(13). Inflammatory responses that may lead to induction of adhesion formation may primarily depend on the production of proinflammatory cytokines interleukin-1 (IL-1), IL-6, and tumor necrosis factor (TNF) (10,14,15). Furthermore, the involvement of other cytokines, such as transforming growth factor b (TGF-b) (16) and chemokines (17,18), in adhesion formation may be also of crucial importance.…”