Peritoneal environment, cytokines and angiogenesis in the pathophysiology of endometriosis

Gazvani, Rafet; Templeton, Alexander Allan

doi:10.1530/rep.0.1230217

Cited by 321 publications

(208 citation statements)

References 17 publications

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“…Additionally, existing studies have documented instances of malignant transformation in endometriosis and malignancies arising from endometriosis, particularly ovarian cancers (25,26). Some studies have suggested that endometriotic lesions show resistance to apoptotic signals together with a capacity for unlimited replication, much like malignant tissues (26)(27)(28).…”

Section: Discussionmentioning

confidence: 99%

The Status of Telomerase Enzyme Activity in Benign and Malignant Gynaecologic Pathologies

Gül¹,

Dündar²,

Bodur³

et al. 2013

Balkan Med J

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Background: Telomeres are essential for the function and stability of eukaryotic chromosomes. Telomerase consists of three subunits: human telomerase reverse transcriptase (hTERT), human telomerase RNA (hTR), and telomerase protein 1 (TP1). The hTERT subunit determines the activity of telomerase as an enzyme and is detected in most human tumors and regenerative cells. Telomerase activity is a useful cancer-cell detecting marker in some types of cancers.Aims: The aim of this study was to assess of telomerase hTERT mRNA in gynaecological tumors for diagnosis of malignancy.Study Design: Cross-sectional study.Methods: A total of 55 gynaecologic tumor samples (35 ovarian, 13 endometrial, 6 cervical and 1 placental site trophoblastic tumor tissue) were obtained at the time of surgery. Quantification of hTERT mRNA was performed in a real-time reverse transcriptase polymerase chain reaction (RT-PCR) using the LightCycler TeloTAGGG hTERT Quantification Kit.Results: It was histopathologically detected that 18 of the tissue samples were malignant and 37 of the samples were benign. 16 of the malignant tissue samples (88.9%) and 3 (8.1%) (endometrial tissue in proliferative phase, mucinous cyst adenoma and endometriosis) of the benign tissue samples were found to be hTERT positive. With the presence of these data, sensitivity and specificity of hTERT for the diagnosis of malignancy were calculated to be 88.9% and 91.9%, respectively. Conclusion:It was suggested that the measurement of telomerase activity in gynaecologic tumors, except for endometrial tissue in the reproductive phase, is a valuable method for pathological investigation.

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Section: Discussionmentioning

confidence: 99%

The Status of Telomerase Enzyme Activity in Benign and Malignant Gynaecologic Pathologies

Gül¹,

Dündar²,

Bodur³

et al. 2013

Balkan Med J

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“…32,33 Among the up-regulated factors, levels of monocyte chemotactic protein-1 (MCP-1), regulated on activation, normal T-cell expressed and secreted (RANTES) and VEGF are elevated by estrogen. 34 -37 To assess the contribution of FKBP52 deficiency to excessive estrogenic effects, concentrations of MCP-1, RANTES, and VEGF in mouse peritoneal fluid were measured by respective enzymelinked immunosorbent assay kits (R&D systems, Minneapolis, MN) according to the manufacturer's protocol.…”

Section: Enzyme-linked Immunosorbent Assaymentioning

confidence: 99%

Deficiency of Immunophilin FKBP52 Promotes Endometriosis

Hirota

Tranguch

Daikoku

et al. 2008

The American Journal of Pathology

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Endometriosis is a common gynecological disease that affects approximately 10% of women of childbearing age. It is characterized by endometrial growth outside the uterus and often results in inflamed lesions, pain, and reduced fertility. Although heightened estrogenic activity and/or reduced progesterone responsiveness are considered to be involved in the etiology of endometriosis, neither the extent of their participation nor the underlying mechanisms are clearly understood. Heterogeneous uterine cell types differentially respond to estrogen and progesterone (P 4 ). P 4 , primarily acting via its nuclear receptor (PR), activates gene transcription and impacts many reproductive processes. Deletion of Fkbp52, an immunophilin cochaperone for PR, results in uterine-specific P 4 resistance in mice, creating an opportunity to study the unique aspects of P 4 signaling in endometriosis. Here we explored the roles of FKBP52 in this disease using Fkbp52 ؊/؊ mice. We found that the loss of FKBP52 encourages the growth of endometriotic lesions with increased inflammation , cell proliferation , and angiogenesis. We also found remarkable down-regulation of FKBP52 in cases of human endometriosis. Our results provide the first evidence corroborated by genetic studies in mice for a potential role of an immunophilin cochaperone in the etiology of human endometriosis. This investigation is highly relevant for clinical application , particularly because P 4 resistance is favorably indicated in endometriosis and other gynecological diseases.

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“…There is abundant evidence demonstrating that endometriosis is accompanied by inflammatory reactions in the peritoneum, resulting in abnormal levels of a variety of cytokines, chemokines and pro-inflammatory factors in the peritoneal fluid (Gazvani & Templeton, 2002;Lousse et al, 2010). It is also well known, that the number of macrophages is increased in the peritoneal fluid of endometriosis patients and that they are in a hyperactive state (Halme & Surrey, 1990;Raiter-Tenenbaum et al, 1998).…”

Section: Prostaglandins As Immune and Inflammatory Mediators In Endommentioning

confidence: 99%

Involvement of Prostaglandins in the Pathophysiology of Endometriosis

Meresman¹,

Olivares²

2012

Endometriosis - Basic Concepts and Current Research Trends

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Peritoneal environment, cytokines and angiogenesis in the pathophysiology of endometriosis

Cited by 321 publications

References 17 publications

The Status of Telomerase Enzyme Activity in Benign and Malignant Gynaecologic Pathologies

The Status of Telomerase Enzyme Activity in Benign and Malignant Gynaecologic Pathologies

Deficiency of Immunophilin FKBP52 Promotes Endometriosis

Involvement of Prostaglandins in the Pathophysiology of Endometriosis

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