Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities

Nisolle, Michelle; Donnez, Jacques

doi:10.1016/s0015-0282(97)00191-x

Cited by 1,076 publications

(728 citation statements)

References 68 publications

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“…The histological distinction in peritoneal, ovarian, and deep-infiltrating endometriosis as three separate entities has been well established [15]. Endometriotic lesions may have typical aspects, purple or blue nodules, or more atypical presentations in 15-30% of patients (peritoneum opacification or circular defects, glandular growths, inflammatory alterations, yellow spots, ovarian adhesions) that may be confused with other non-endometriotic lesions [16].…”

Section: Discussionmentioning

confidence: 99%

Chronic pelvic pain and the role of exploratory laparoscopy as diagnostic and therapeutic tool: a retrospective observational study

et al. 2018

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Background: Forty percent of exploratory laparoscopies are performed for chronic pelvic pain (CPP). However, a final diagnosis is still unreported in 35% of the patients. We decided to evaluate the identification of pathological lesions and the improvement of painful symptoms in patients with CPP and normal physical examination and imaging and who are scheduled for exploratory laparoscopy. The prospective study was designed in a tertiary referral center for endometriosis. Forty-eight patients complaining of CPP and scheduled for exploratory laparoscopy were included. Pelvic pain intensity was assessed using the visual analogue pain scale (VAS), and at inclusion, negative clinical and imaging assessments were required. During exploratory laparoscopy, the recognized lesions were reported and different surgical treatment options were performed depending on the location of the lesion. Results: In 98% of the cases, exploratory laparoscopy demonstrated the presence of pelvic anomalies that had not been diagnosed at the time of clinical and imaging examination. After surgery, a significant improvement of CPP has been demonstrated in 24 (59%) patients with VAS < 5 postoperatively. Conclusions: Exploratory laparoscopy is reasonable in patients complaining of CPP, allowing a final diagnosis in a high percentage of patients and a significant improvement in pain symptom in 59% of the cases. This study was retrospectively registered by our local Ethics Committee on February 7, 2018 (B412201835729).

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Section: Discussionmentioning

confidence: 99%

Chronic pelvic pain and the role of exploratory laparoscopy as diagnostic and therapeutic tool: a retrospective observational study

et al. 2018

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“…In our series, all cases of rectovaginal septum and vaginal involvement were associated with other sites of deep pelvic endometriosis. Although rare primary sites of endometriosis of the rectovaginal septum have been described 21 ,Sampson 22 suggested that the rectovaginal septum is generally affected secondarily to the peritoneum of the pouch of Douglas, which is directly in contact with the top of the rectovaginal septum.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic accuracy of transvaginal sonography for deep pelvic endometriosis

Bazot

Thomassin

Hourani

et al. 2004

Ultrasound in Obstet & Gyne

294

275

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“…Ovarian and peritoneal endometrioses are thought to have different pathogenetic origins. Ovarian endometriotic cysts could arise from invagination and metaplasia of ovarian epithelium lining, and peritoneal endometriosis is thought to be the consequence of implantation of shed endometrium (22).…”

Section: Discussionmentioning

confidence: 99%

Reduction of apoptosis and proliferation in endometriosis

Béliard

Noël

Foidart

2004

Fertility and Sterility

151

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Objective: To evaluate whether endometriosis could be related to an impaired balance between apoptosis and proliferation, two processes which could be modulated by hormonal status.Design: Immunohistochemical study.Setting: Academic research laboratory. Intervention(s):Endometriotic samples obtained from peritoneum of women aged 26-40 years who were undergoing laparoscopy for pain or infertility. Main Outcome Measure(s):Apoptotic cells were detected with the use of the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) assay. The production of p53 and bcl-2, estrogen and Progesterone (P) receptors, and cellular proliferation were assessed by immunohistochemistry in eutopic and ectopic endometria from 30 patients with endometriosis throughout the menstrual cycle. Results were compared with those from normal endometria from 15 fertile patients. Result(s):Endometriotic lesions were characterized by reduced TUNEL and p53 stainings and by enhanced bcl-2 staining. No correlation between apoptosis and estrogen receptor or P receptor levels was found. A lower amount of steroid receptor was found in endometriotic tissues, without cyclic modulation, compared with the eutopic endometrium. Conclusion(s):Our results suggest that when endometrial tissue is located at ectopic locations, it differs from eutopic endometrium by its proliferation rate, steroid hormone levels, and markers of apoptosis. A reduced sensitivity of endometriotic cells to apoptosis could promote the dissemination and implantation of these cells to ectopic sites.

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Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities

Cited by 1,076 publications

References 68 publications

Chronic pelvic pain and the role of exploratory laparoscopy as diagnostic and therapeutic tool: a retrospective observational study

Chronic pelvic pain and the role of exploratory laparoscopy as diagnostic and therapeutic tool: a retrospective observational study

Diagnostic accuracy of transvaginal sonography for deep pelvic endometriosis

Reduction of apoptosis and proliferation in endometriosis

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