Peritoneal endometriosis is an inflammatory disease

Donnez, Jacques

doi:10.2741/e358

Cited by 103 publications

(14 citation statements)

References 122 publications

(206 reference statements)

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“…The central role in endometriosis belongs to local inflammation, which triggers the development of the disease and induces pain and infertility [21]. In support of this statement, a wide range of studies reported that the peritoneal fluid of endometriotic patients contained high levels of macrophages and immune cells, which secrete cytokines, angiogenic factors, and growth factors [22].…”

Section: Endometriosis-an Inflammatory Diseasementioning

confidence: 98%

“…Alternatively, in vivo, the integrative activation of NF-kappa B subunits has been highlighted in ectopic areas of endometrial tissue [34]. The researcher's common point of view is that in endometriosis, NF-kappa B activated macrophages release IL-1, 6, 8, COX-2, TNF-alpha, and vascular endothelial growth factor (VEGF); thus, perpetuating the inflammatory pathway [21].…”

Section: Endometriosis-an Inflammatory Diseasementioning

confidence: 99%

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Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives

Anastasiu

Moga

Neculau

et al. 2020

IJMS

112

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Background: Early and accurate diagnosis of endometriosis is crucial for the management of this benign, yet debilitating pathology. Despite the advances of modern medicine, there is no common ground regarding the pathophysiology of this disease as it continues to affect the quality of life of millions of women of reproductive age. The lack of specific symptoms often determines a belated diagnosis. The gold standard remains invasive, surgery followed by a histopathological exam. A biomarker or a panel of biomarkers is easy to measure, usually noninvasive, and could benefit the clinician in both diagnosing and monitoring the treatment response. Several studies have advanced the idea of biomarkers for endometriosis, thereby circumventing unnecessary invasive techniques. Our paper aims at harmonizing the results of these studies in the search of promising perspectives on early diagnosis. Methods: We selected the papers from Google Academic, PubMed, and CrossRef and reviewed recent articles from the literature, aiming to evaluate the effectiveness of various putative serum and urinary biomarkers for endometriosis. Results: The majority of studies focused on a panel of biomarkers, rather than a single biomarker and were unable to identify a single biomolecule or a panel of biomarkers with sufficient specificity and sensitivity in endometriosis. Conclusion: Noninvasive biomarkers, proteomics, genomics, and miRNA microarray may aid the diagnosis, but further research on larger datasets along with a better understanding of the pathophysiologic mechanisms are needed.

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Section: Endometriosis-an Inflammatory Diseasementioning

confidence: 98%

Section: Endometriosis-an Inflammatory Diseasementioning

confidence: 99%

Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives

Anastasiu

Moga

Neculau

et al. 2020

IJMS

112

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“…ROS production enhances NF-κB in peritoneal macrophages leading to cell growth, angiogenesis and inflammation in endometriosis cells [44].…”

Section: Introductionmentioning

confidence: 99%

Curcumin and Endometriosis

Vallée

Lecarpentier²

2020

IJMS

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Endometriosis is one of the main common gynecological disorders, which is characterized by the presence of glands and stroma outside the uterine cavity. Some findings have highlighted the main role of inflammation in endometriosis by acting on proliferation, apoptosis and angiogenesis. Oxidative stress, an imbalance between reactive oxygen species and antioxidants, could have a key role in the initiation and progression of endometriosis by resulting in inflammatory responses in the peritoneal cavity. Nevertheless, the mechanisms underlying this disease are still unclear and therapies are not currently efficient. Curcumin is a major anti-inflammatory agent. Several findings have highlighted the anti-oxidant, anti-inflammatory and anti-angiogenic properties of curcumin. The purpose of this review is to summarize the potential action of curcumin in endometriosis by acting on inflammation, oxidative stress, invasion and adhesion, apoptosis and angiogenesis.

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“…It is now well established that chronic inflammatory milieu in the peritoneal cavity of endometriosis patients contributes to pain and infertility associated with the disease 3 . Despite decades of research, current treatment option transiently alleviate but do not cure the disease.…”

Section: Introductionmentioning

confidence: 99%

A balancing act: RNA binding protein HuR/TTP axis in endometriosis patients

Khalaj

Ahn

Bidarimath

et al. 2017

Sci Rep

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Endometriosis, a major reproductive pathology affecting 8–10% of women is characterized by chronic inflammation and immune dysfunction. Human antigen R (HuR) and Tristetraprolin (TTP) are RNA binding proteins that competitively bind to cytokines involved in inflammation including: tumor necrosis factor alpha (TNF-α), granulocyte macrophage colony stimulating factor (GM-CSF), interleukin 6 (IL-6) among others, and stabilize and destabilize them, respectively. The aim of this study was to examine RNA binding protein (RNABP) HuR/TTP axis in endometriosis patients compared to menstrual stage matched healthy fertile controls in hopes of better understanding their contribution to the pathogenesis of endometriosis. Additionally, using a targeted in vitro siRNA approach, we examined whether knock-down of TTP can play a functional role on other RNABPs that competitively bind to inflammatory targets of TTP in both endometriotic and endometrial epithelial cell lines. Our results suggest that RNABPs TTP and HuR are dysregulated in endometriotic lesions compared to matched eutopic patient samples as well endometrium from healthy controls. Silencing of TTP in endometriotic and endometrial epithelial cells revealed differential response to inflammatory cytokines and other RNABPs. Our results suggest potential involvement of HuR/TTP RNA binding protein axis in regulation of inflammation in endometriosis.

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Peritoneal endometriosis is an inflammatory disease

Cited by 103 publications

References 122 publications

Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives

Biomarkers for the Noninvasive Diagnosis of Endometriosis: State of the Art and Future Perspectives

Curcumin and Endometriosis

A balancing act: RNA binding protein HuR/TTP axis in endometriosis patients

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