Peritoneal Effusion in a Dog Secondary to Visceral Mast Cell Tumor

Souza, Maria-Ines; Torres, L F; Rocha, Noeme Sousa; Takahira, Regina Kiomi; Mamprim, Maria Jaqueline; Burini, Caio Henrique Paganini; Bandarra, Enio Pedone; Figueiredo, Luísa

doi:10.1159/000327194

Cited by 8 publications

(6 citation statements)

References 8 publications

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“…However, abdominocentesis and analysis of the recovered fluid may be helpful in addition to aspirates or biopsies of abdominal organs. Numerous neoplastic mast cells were found in the peritoneal effusion of one dog with visceral mast cell disease 36 . Care must be taken in interpreting the aspirates, as small numbers of mast cells can be a common finding with serous effusions 37…”

Section: Discussionmentioning

confidence: 99%

Ultrasonographic findings in abdominal mast cell disease: a retrospective study of 19 patients

Sato¹,

Solano²

2004

Vet Radiology Ultrasound

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A retrospective survey from January 1989 to January 1999 of Tufts University Foster Hospital for Small Animals radiology records of 12 dogs and seven cats with cytologically or histopathologically confirmed abdominal mast cell disease was performed. Ultrasound changes in hepatic mast cell infiltration in dogs included a subjective increase in size, a diffuse increase in echogenicity, and one or more hypoechoic nodules. Ultrasound findings in the affected canine spleen included one or more hypoechoic nodules and a subjective increase in size. Two ultrasonographically unremarkable canine livers and one unremarkable spleen were found to be infiltrated by mast cells. The mast cell-infiltrated feline spleen was subjectively increased in size, mottled, irregular, or contained nodules. The affected lymph nodes in both dogs and cats were hypoechoic or inhomogeneous, subjectively increased in size, and rounded. Gastrointestinal involvement in cats was characterized by a thickened ileocecocolic junction or colon with loss of wall layering. Mast cells were not found in the gastrointestinal tract in any dog. One dog with mast cell infiltrate of the kidneys had multiple hypoechoic nodules in the cortex that distorted the outer contour of the kidney. Although these findings are not specific to the disease in either species, abdominal ultrasound is considered a useful tool for determining the extent of disease in small-animal patients with mast cell tumor if used in conjunction with histopathology or cytology.

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Section: Discussionmentioning

confidence: 99%

Ultrasonographic findings in abdominal mast cell disease: a retrospective study of 19 patients

Sato¹,

Solano²

2004

Vet Radiology Ultrasound

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“…Mast cell tumours may exert systemic effects related to the secretion of biologically active substances by degranulating tumour cells (23) sometimes resulting in gastric and duodenal ulceration due to histamine release (7,14,21,30,44,83 MCT can result in an animal's death because of the paraneoplastic disorders or owners may choose euthanasia because of the debilitating effects of the tumour burden. Even non-resectable local disease with substantial ulceration, bleeding or discomfort that appear to be diminishing the pet's quality of life can be severe enough to prompt the owner to consider euthanasia (98).…”

Section: Canine Mast Cell Tumours Epidemiology and Aetiologymentioning

confidence: 99%

Mast cells and canine mast cell tumours. A review

Misdorp

2004

Veterinary Quarterly

102

103

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“…Disseminated MCT in the liver is almost always preceded by undifferentiated primary cutaneous lesions. 12,[19][20][21][22] Visceral MCT is uncommon in dogs and is reported to have an extremely poor prognosis. 12 In our case, MCT was detected by periodic FNA of the liver without cutaneous lesions.…”

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confidence: 99%

Hepatosplenic lymphoma and visceral mast cell tumor in the liver of a dog with synchronous and multiple primary tumors

Akiyoshi

Hisasue

Asakawa

et al. 2022

Veterinary Clinical Pathol

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An 11‐year‐old spayed female American Cocker Spaniel was presented with a 4‐week history of anorexia and a 1‐week history of abdominal distension. Clinicopathologic and imaging abnormalities included intra‐abdominal hemorrhage, granular lymphocytes (GLs) in abdominal fluid smears, a splenic mass, and hepatomegaly with diffuse multiple hypoechogenic nodules. Based on the cytologic, histologic, and immunohistochemical evaluation of the spleen and liver, the diagnosis was hepatosplenic T‐cell lymphoma (HSTCL) of GLs. Postoperatively, the dog was maintained in good condition with chemotherapy (ACNU [nimustine], L‐asparaginase, and prednisolone). However, on day 85, ultrasound‐guided fine‐needle aspiration of the liver revealed a proliferation in neoplastic mast cells not associated with the GLs. The dog was diagnosed with a visceral mast cell tumor (MCT) originating from the liver. The chemotherapy was switched to vinblastine and toceranib. The dog remained in good condition until day 141 but died due to the progression of MCT on day 158. Liver cytology on day 155 showed no GLs, although HSTCL is thought to be resistant to chemotherapy. After the definitive diagnosis of HSTCL, we monitored this patient's response to chemotherapy with blood tests, including complete blood counts, ultrasound imaging, and cytologic aspirates of liver. Although canine HSTCL has a poor prognosis, the possibility of a new neoplasm, including visceral MCT, should be considered. Periodic liver cytology might be worthwhile in dogs receiving chemotherapy for HSTCL.

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Peritoneal Effusion in a Dog Secondary to Visceral Mast Cell Tumor

Cited by 8 publications

References 8 publications

Ultrasonographic findings in abdominal mast cell disease: a retrospective study of 19 patients

Ultrasonographic findings in abdominal mast cell disease: a retrospective study of 19 patients

Mast cells and canine mast cell tumours. A review

Hepatosplenic lymphoma and visceral mast cell tumor in the liver of a dog with synchronous and multiple primary tumors

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