Peritoneal Dialysis Zoonotic Bacterial Peritonitis with &lt;b&gt;&lt;i&gt;Staphylococcus pseudintermedius&lt;/i&gt;&lt;/b&gt;

Dahbour, Layth; Gibbs, Jeffrey T.; Coletta, Christian; Hummell, Jeannine; Al-Sarie, Mohammad; Kahlon, Navkirat Pannu; Akpunonu, Basil E.

doi:10.1159/000508126

Cited by 6 publications

(3 citation statements)

References 17 publications

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“…Colonies are medium-sized, raised, and unpigmented, and display a large incomplete β-hemolysis and small complete δ-hemolysis either alone or in combination (double hemolysis) on sheep or bovine blood agar. As a zoonotic bacterium, S. pseudintermedius can cause catheter-related bloodstream infections ( 47 ), sinonasal infections ( 48 ), bacterial peritonitis ( 49 ), and venous access port infections ( 36 ). As an opportunistic pathogen, S. pseudintermedius is associated with skin, ear, and post-surgical infections in the domestic animals, especially dogs ( 50 – 52 ).…”

Section: Discussionmentioning

confidence: 99%

Antibiotic resistance, biofilm formation, and virulence factors of isolates of staphylococcus pseudintermedius from healthy dogs and dogs with keratitis

Wang

Guo

et al. 2022

Front. Vet. Sci.

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Canine bacterial keratitis is a common infection that can potentially threaten vision. Staphylococcus pseudintermedius (S. pseudintermedius) is an opportunistic pathogen that has been isolated from the canine conjunctival sac but there are only a few reports on the role of this bacterium in canine keratitis. This study focused on the distribution rate of S. pseudintermedius in the canine conjunctival sac, and the antibiotic resistance, biofilm-producing ability, and dissemination of virulence factors in strains of S. pseudintermedius isolated from healthy dogs and dogs with keratitis. The study included 35 healthy dogs and 40 dogs with keratitis. Bacterial species were confirmed by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI–TOF MS). Strains of S. pseudintermedius were screened for resistance against nine different antibiotics by the Kirby–Bauer assay. The ability to produce biofilm was investigated by microtiter plate assay (MtP) and amplification of icaA and icaD genes. Virulence factors in the strains were also evaluated. A total of 132 aerobic bacteria were isolated from the 119 samples in the study. Among them, 67 bacterial strains were isolated from 70 eyes of healthy dogs, and 65 bacterial strains were isolated from 49 eyes of dogs with keratitis. The prevalence of S. pseudintermedius, which was the most frequent bacterial isolate in both the groups, was 20.9% in the healthy group and 23.08% in the keratitis group. Most of the isolates of S. pseudintermedius were sensitive to rifampin (96.6%), oxacillin (100%), and neomycin (96.6%), and resistant to tetracycline (96.6%). Virulence factors such as lip (96.6%), hlgB (96.6%), and hlgA (96.6%) were found in most of the isolates, and 89.66% of isolates were classed as biofilm producers. In conclusion, S. pseudintermedius was the common bacterium in the conjunctivital sac of the healthy dogs and dogs with keratitis in Yangzhou, China, and the presence of virulence factors and biofilm-formation ability were high in the strains isolated from the dogs with keratitis.

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Section: Discussionmentioning

confidence: 99%

Antibiotic resistance, biofilm formation, and virulence factors of isolates of staphylococcus pseudintermedius from healthy dogs and dogs with keratitis

Wang

Guo

et al. 2022

Front. Vet. Sci.

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“…pseudintermedius in humans from 2006 when S . pseudintermedius was first reported in a human infection to 1 December 2022 [ 4 , 6 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 20 , 22 , 38 , 40 , 41 , 42 , 43 , 44 , 52 , 53 , 55 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 ]. A summary of all reported human S .…”

Section: The Zoonotic Transmission Colonization/infections and Epidem...mentioning

confidence: 99%

Human Colonization and Infection by Staphylococcus pseudintermedius: An Emerging and Underestimated Zoonotic Pathogen

2023

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S. pseudintermedius is a known resident of the skin and mucous membranes and a constituent of the normal microbiota of dogs. It has also been recognized as an opportunistic and zoonotic pathogen that is able to colonize humans and cause severe diseases, especially in immunocompromised hosts. Most importantly, methicillin-resistant S. pseudintermedius (MRSP), which is intrinsically multidrug-resistant, has emerged with serious public health consequences. The epidemiological situation is further exacerbated with reports of its zoonotic transmission and human infections which have been mostly attributed to the increasing frequency of dog ownership and close contact between dogs and humans. Evidence on the zoonotic transmission of MRSP from pet dogs to humans (such as dog owners, small-animal veterinarians, and other people in close proximity to dogs) is limited, especially due to the misidentification of S. pseudintermedius as S. aureus. Despite this fact, reports on the increasing emergence and spread of MRSP in humans have been increasing steadily over the years since its first documented report in 2006 in Belgium. The emergence of MRSP strains has further compromised treatment outcomes in both veterinary and human medicine as these strains are resistant to beta-lactam antimicrobials usually prescribed as first line treatment. Frustratingly, the limited awareness and surveillance of the zoonotic transmission of S. pseudintermedius have underestimated their extent of transmission, prevalence, epidemiology, and public health significance. In order to fill this gap of information, this review focused on detailed reports on zoonotic transmission, human colonization, and infections by S. pseudintermedius, their pathogenic features, antimicrobial resistance profiles, epidemiology, risk factors, and treatment. In writing this review, we searched Web of Science, PubMed, and SCOPUS databases using the keyword “Staphylococcus pseudintermedius AND humans”. A phylogenetic tree to determine the genetic relatedness/diversity of publicly available genomes of S. pseudintermedius was also constructed.

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“…25,26 In addition, S. pseudintermedius had been isolated in patients who developed peritoneal dialysis-associated peritonitis. 27 The organism had also been isolated in a graft-versus-host disease-related wound infection caused by a multidrug-resistant strain. 25 Furthermore, S. pseudintermedius had been isolated in a 50-year-old female patient who has a history of bilateral lung transplantation.…”

Section: Clinical Presentation Of Infection Caused By Staphylococcus ...mentioning

confidence: 99%

An overview of human infections caused by <em>Staphylococcus pseudintermedius:</em> A zoonotic risk of the oldest friend

Priyantha¹

2022

Sri Lankan J Infec Dis

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Staphylococcus pseudintermedius is colonized in 90% of healthy dogs and the infection has also been reported in humans who have close contact with dogs. S. pseudintermedius is a Gram positive coagulase positive coccus which is an opportunistic pathogen. Human infection has been reported less frequently either due to misidentification or misdiagnosis or to underreporting. The objective of this overview is to highlight the epidemiology, clinical presentation, importance of laboratory tests and antimicrobial resistance of S. pseudintermedius in humans.Human infections of S. pseudintermedius have been reported as case studies or clusters of infections in the literature. Several cases have been reported among the adult population, and in patients with metabolic diseases such as diabetes mellitus, immunocompromised states such as AIDS, cancers, and autoimmune diseases. The organism had been isolated and identified both in healthy people and individuals with adverse clinical outcomes. S. pseudintermedius causes skin and soft tissue infections, catheter associated infections and surgical site infections in humans. The incidence of skin and soft tissue infection by S. pseudintermedius in humans was 0.025% in Canada. Methicillin resistance S. pseudintermedius (MRSP) has been isolated both in healthy people and associated with clinical infections. MRSP is often multidrug resistant and therapeutic options are limited. Multidrug resistance has been detected in methicillin susceptible S. pseudintermedius (MSSP). Close association of a canine host is the major risk factor in humans and vulnerable individuals need to be persuaded to practice hygienic practices to minimize the risk of zoonotic infection.In conclusion, differentiation of S. pseudintermedius from S. aureus is required to understand the epidemiology of the disease, diagnosis, clinical presentation, and further interpretation of antimicrobial resistance in the human clinical context. Suitable hygienic practices post handling of dogs and improvement of laboratory facilities would help minimize the incidence of S. pseudintermedius infections in humans.

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Peritoneal Dialysis Zoonotic Bacterial Peritonitis with <b><i>Staphylococcus pseudintermedius</i></b>

Cited by 6 publications

References 17 publications

Antibiotic resistance, biofilm formation, and virulence factors of isolates of staphylococcus pseudintermedius from healthy dogs and dogs with keratitis

Antibiotic resistance, biofilm formation, and virulence factors of isolates of staphylococcus pseudintermedius from healthy dogs and dogs with keratitis

Human Colonization and Infection by Staphylococcus pseudintermedius: An Emerging and Underestimated Zoonotic Pathogen

An overview of human infections caused by <em>Staphylococcus pseudintermedius:</em> A zoonotic risk of the oldest friend

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