Peritoneal Dialysis–Related Peritonitis from Carbapenemase-Producing <i>Klebsiella pneumoniae</i> with OXA-48 Type Gene

Introduction. While colonization by Staphylococcus aureus in haemodialysis patients has been assessed, knowledge about colonization by beta-lactam-resistant Gram-negative bacilli is still limited. Aim. To describe clinical and molecular characteristics in haemodialysis patients colonized by S. aureus (MSSA-MRSA) and beta-lactam-resistant Gram-negative bacilli in an ambulatory renal unit. Methodology. The study included patients with central venous catheters in an outpatient haemodialysis facility in Medellín, Colombia (October 2017–October 2018). Swab specimens were collected from the nostrils and skin around vascular access to assess colonization by S. aureus (MSSA-MRSA). Stool samples were collected from each patient to evaluate beta-lactam-resistant Gram-negative bacilli colonization. Molecular typing included PFGE, multilocus sequence typing (MLST), spa typing and enterobacterial repetitive intergenic consensus-PCR (ERIC). Clinical information was obtained from medical records and personal interview. Results. A total of 210 patients were included in the study. S. aureus colonization was observed in 33.8 % (n=71) of the patients, 4.8 % (n=10) of which were colonized by methicillin-resistant S. aureus . Stool samples were collected from 165 patients and of these 41.2 % (n=68) and 11.5 % (n=19) were colonized by extended-spectrum-beta-lactamase-producing (ESBL) and carbapenem-resistant bacilli, respectively. Typing methods revealed high genetic diversity among S. aureus and ESBL-producing Gram-negative bacilli (ESBL-GNB). Antibiotic use and hospitalization in the previous 6 months were observed in more than half of the studied population. Conclusion. The high colonization by ESBL-GNB in haemodialysis patients shows evidence for the need for stronger surveillance, not only for S. aureus but also for multidrug-resistant bacilli in order to avoid their spread. Additionally, the high genetic diversity suggests other sources of transmission outside the renal unit instead of horizontal transmission between patients.

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“…Other carbapenemases, such as OXA-48 and NDM, have been reported in isolates of K. pneumoniae, causing infections in dialysis patients [34,35].…”

Section: Discussionmentioning

confidence: 99%

High frequency of colonization by diverse clones of beta-lactam-resistant Gram-negative bacilli in haemodialysis: different sources of transmission outside the renal unit?

Vanegas

Salazar-Ospina

Montoya-Urrego

et al. 2020

Journal of Medical Microbiology

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“…Colistin has been used to treat peritonitis in PD patients with case reports from Korea, 11 Singapore 12 and Hong Kong. 13 However, those cases, unlike ours involved removal of the PD catheter because of slow response to antibiotics.…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of carbapenemase producing Enterobacteriaceae peritonitis: ‘Old therapy for a new bug’

et al. 2020

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Multidrug-resistant organisms cause significant morbidity and mortality. Infections due to resistant gram-negative bacilli are increasingly being reported. For years, carbapenem antibiotics have been successfully used to treat infections due to resistant Enterobacteriaceae, such as Escherichia coli and Klebsiella pneumoniae, including those producing extended spectrum β-lactamases, a subset of β-lactamase enzymes that confer broad resistance to penicillins and cephalosporins. More recently, carbapenem-resistant Enterobacteriaceae have emerged as pathogenic organisms, which confer broad resistance to most β-lactam antibiotics including ‘last-line’ carbapenems. However, different types of carbapenemases confer diverse spectra of antibiotic resistance. Here, we describe the case of an 84-year-old lady on peritoneal dialysis (PD) for 3 years who, on developing carbapenem-resistant Klebsiella pneumoniae PD peritonitis, was successfully treated with colistin, an antimicrobial agent first used in the 1950s.

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Peritoneal Infections in Peritoneal Dialysis (PD Peritonitis)

Regunath¹,

Ludwig²,

Khanna³

2021

Nolph and Gokal's Textbook of Peritoneal Dialysis

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Peritoneal Dialysis–Related Peritonitis from Carbapenemase-Producing Klebsiella pneumoniae with OXA-48 Type Gene

Cited by 7 publications

References 6 publications

High frequency of colonization by diverse clones of beta-lactam-resistant Gram-negative bacilli in haemodialysis: different sources of transmission outside the renal unit?

High frequency of colonization by diverse clones of beta-lactam-resistant Gram-negative bacilli in haemodialysis: different sources of transmission outside the renal unit?

Successful treatment of carbapenemase producing Enterobacteriaceae peritonitis: ‘Old therapy for a new bug’

Peritoneal Infections in Peritoneal Dialysis (PD Peritonitis)

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