Peritoneal Dialysis in Diabetic End-Stage Renal Disease

Misra, Madhukar; Khanna, Ramesh

doi:10.1007/978-0-387-78940-8_28

Cited by 2 publications

(2 citation statements)

References 115 publications

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“…Other studies have reported risk factors of higher BMI and diabetes mellitus, 11,26 but these were not observed to be associated with an increased risk of peritonitis in our cohort. This result is important as diabetes and those with a higher BMI can be successfully managed as a PD patient in our unit.…”

Section: Discussioncontrasting

confidence: 92%

Risk factors for peritoneal dialysis‐related peritonitis: Can we reduce the incidence and improve patient selection?

Kotsanas¹,

Polkinghorne

Korman³

et al. 2007

Nephrology

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Section: Discussioncontrasting

confidence: 92%

Risk factors for peritoneal dialysis‐related peritonitis: Can we reduce the incidence and improve patient selection?

Kotsanas¹,

Polkinghorne

Korman³

et al. 2007

Nephrology

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“…D iabetes mellitus (DM) is prevalent among patients undergoing chronic peritoneal dialysis (PD) (1). Mean comorbidity scores in diabetic individuals who initiate PD are significant, and compared with nondiabetic patients, patients with diabetes have a clinical course characterized by poor standards of rehabilitation and quality of life, a high incidence of cardiovascular events, and shortened life expectancy.…”

mentioning

confidence: 99%

Correlation between Glycemic Control and the Incidence of Peritoneal and Catheter Tunnel and Exit-Site Infections in Diabetic Patients Undergoing Peritoneal Dialysis

et al. 2014

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♦ Background: Diabetes mellitus, especially if complicated by poor glycemic control, portends an increased risk of infection. The significance of this association in the case of diabetic patients undergoing peritoneal dialysis (PD) has not been assessed. ♦ Methods: Using a retrospective observational design, we analyzed the association between glycemic control at the start of PD (estimated from glycosylated hemoglobin levels) and the risk of peritoneal and catheter tunnel and exit-site infections during follow-up in 183 incident patients on PD. We used the median value of glycosylated hemoglobin to classify patients into good (group A) or poor (group B) glycemic control groups. We applied multivariate strategies of analysis to control for other potential predictors of PD-related infection. ♦ Results: Groups A and B differed significantly in age, dialysis vintage, use of insulin, and rate of Staphylococcus aureus carriage. Neither the incidence (0.60 episodes in group A vs 0.56 episodes in group B per patient-year) nor the time to a first peritoneal infection (median: 42 months vs 38 months) differed significantly between the study groups. In contrast, group B had a significantly higher incidence of catheter tunnel and exit-site infections (0.23 episodes vs 0.12 episodes per patient-year) and shorter time to a first infection episode (64 months vs 76 months, p = 0.004). The difference persisted in multivariate analysis (adjusted hazard ratio: 2.65; 95% confidence interval: 1.13 to 6.05; p = 0.013). We observed no differences between the study groups in the spectrum of causative organisms or in the outcomes of PD-related infections. ♦ Conclusions: Poor glycemic control is a consistent predictor of subsequent risk of catheter tunnel and exit-site infection, but not of peritoneal infection, among diabetic patients starting PD therapy.

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Peritoneal Dialysis in Diabetic End-Stage Renal Disease

Cited by 2 publications

References 115 publications

Risk factors for peritoneal dialysis‐related peritonitis: Can we reduce the incidence and improve patient selection?

Risk factors for peritoneal dialysis‐related peritonitis: Can we reduce the incidence and improve patient selection?

Correlation between Glycemic Control and the Incidence of Peritoneal and Catheter Tunnel and Exit-Site Infections in Diabetic Patients Undergoing Peritoneal Dialysis

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