Peritoneal Dialysis can be an Option for Dominant Polycystic Kidney Disease: An Observational Study

Janeiro, Darío; Pórtoles, José; Tato, A; López–Sánchez, Paula; Peso, Gloria del; Rivera, Machado; Castellano, Inés; Fernández‐Reyes, María José; Perez-Gomez, María Vanessa; Ortega, Mayra; Martínez-Miguel, Patricia; Felipe, C.; Caparrós, Guadalupe; Ortíz, Alberto; Selgas, Rafael

doi:10.3747/pdi.2014.00029

Cited by 22 publications

(40 citation statements)

References 20 publications

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“…Some studies reported that dialysate leak was more common in patients with ADPKD (Fletcher et al, 1994;Hadimeri et al, 1998), but only one ADPKD patient in our study developed dialysate leak and transferred to HD. Our results were similar to the findings by Li et al (2011) and Janeiro et al (2015).…”

Section: Discussionsupporting

confidence: 93%

“…Kumar et al (2008) observed a cohort of 56 ADPKD patients who were started on PD therapy over a 12-year period and found that the long-term outcomes (mortality and technique survival) were similar to those of a matched control group of non-diabetic patients with bilateral small kidneys. Li et al (2011) andJaneiro et al (2015) also found similar outcomes between ADPKD patients and controls. In our retrospective study, no significant differences were observed in the patient or technique survival between ADPKD patients and matched controls.…”

Section: Discussionmentioning

confidence: 52%

“…del Peso et al (2003) and Fletcher et al (1994) reported that ADPKD patients on PD therapy may experience more abdominal wall hernias and peritoneal leaks than patients with a different type of nephropathy. However, in recent years, some studies from the UK, France, Spain, and Hong Kong Special Administrative Region (China) reported that PD in ADPKD patients has similar patient and technical survivals compared with non-ADPKD patients (Kumar et al, 2008;Li et al, 2011;Lobbedez et al, 2011;Janeiro et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Peritoneal dialysis for autosomal dominant polycystic kidney disease: a retrospective study

Xie

Xiang

et al. 2016

J. Zhejiang Univ. Sci. B

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Abstract:To describe the long-term clinical outcomes of patients with autosomal dominant polycystic kidney disease (ADPKD) who are on peritoneal dialysis (PD) therapy. We performed a retrospective matched-cohort analysis comparing the clinical outcomes of 30 ADPKD patients with those of 30 non-diabetic patients who had bilateral small kidneys between July 1 2007 and July 31 2014. The patient groups were matched by age, gender, and time of PD initiation. There were no significant differences in the demographic or biochemical parameters, comorbid conditions, residual glomerular filtration rate, or Charlson comorbidity score at the beginning of PD. The median renal volume was 1315 ml for the ADPKD group and 213 ml for the control group. Patients with ADPKD had similar 3-year patient survival (90.6% versus 86.3%, P=0.807) and technique survival (89.2% versus 74.3%, P=0.506) compared with non-ADPKD patients. Also, there was no significant difference in the peritonitis-free survival between the ADPKD and control groups (P=0.22), and rates of peritonitis were similar (0.19 versus 0.21 episodes per patient-year, P=0.26). No differences were observed in the incidence of PD-related complications, such as hernia and dialysate leak. ADPKD is not a contraindication for PD, and a subgroup of ADPKD patients with relatively small kidney volume can be treated using PD.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 52%

Section: Introductionmentioning

confidence: 99%

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Peritoneal dialysis for autosomal dominant polycystic kidney disease: a retrospective study

Xie

Xiang

et al. 2016

J. Zhejiang Univ. Sci. B

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“…The outcomes in PKD and non-PKD patients on PD Dialysis adequacy. For the 9 studies [9,16,17,[21][22][23][24][25][26] which examined the association of Kt/V in PKD and non-PKD patients and 4 studies [16,22,24,26] examined the association of dialysate to-plasma ratios of creatinine (D: Pcr) at 4h in PKD and non-PKD patients. Whether Kt/V or D: Pcr (4h), there was no difference in terms of dialysis adequacy for each other (Kt/V, SMD: -0.02, 95% CI: -0.12-0.08; D: Pcr (4h), SMD: -0.10, 95%CI: -0.26-0.06).…”

Section: Literature Searchmentioning

confidence: 99%

“…In recent years, scale observational studies [16][17][18][19][20] suggested that PKD was not a contraindication for PD. Moreover, it has even been suggested that PD may be associated with a better prognosis in PKD than that of non-PKD patients [9,16,17,19,[21][22][23][24][25][26]. Therefore, it has raised concern as to whether PD is appropriate for PKD patients.…”

Section: Introductionmentioning

confidence: 99%

Is Peritoneal Dialysis a Suitable Renal Replacement Therapy Option for Polycystic Kidney Disease Patients?

Zhang¹,

Dou²,

Wang³

et al. 2018

Kidney Blood Press Res

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Background/Aims: Mounting clinical experience and evidence from scale observational studies have suggested that polycystic kidney disease (PKD) was not a contraindication for peritoneal dialysis (PD). Recent studies have reported that PD may be associated with a better prognosis in PKD than that of non-PKD patients. To solve the problem, we performed a systematic review and comprehensive meta-analysis to compare the outcomes between PKD and non-PKD patients on PD and the all-cause mortality between patients with PKD on PD and hemodialysis (HD). Methods: We conducted a systematic literature using electronic databases (PubMed, Ovid, Embase and Web of Science) to identify the studies reporting the endpoint events of PKD/non-PKD patients with PD and the all-cause mortality between patients with PKD on PD and HD, such as dialysis adequacy, technique failure, PD-related complications, the mode of RRT change, and all-cause mortality. We searched the literature published February 2018 or earlier. We used both fix-effects and random-effects models to calculate the overall effect estimate. A sensitivity analysis and subgroup analysis were performed to find the origin of heterogeneity. Results: 12 studies with a total of 17,040 patients reported the endpoint events of PKD/non-PKD patients with PD. No significant difference was observed on dialysis adequacy (Kt/V, SMD: -0.02, 95%CI: -0.12–0.08; D: Pcr (4h), SMD: -0.10, 95% CI: -0.26–0.06), technique failure (RR: 0.97, 95%CI: 0.78-1.20), RRT change (RR: 0.96, 95%CI: 0.77-1.19), total PD-associated complications (RR: 1.0, 95%CI: 0.91-1.09) and all-cause mortality (RR: 0.40, 95%CI: 0.33–0.47) in PKD patients, compared with non-PKD subjects undergoing PD. However, the proportion of renal transplantation in PKD patients was higher than that of non-PKD patients (RR: 2.04, 95%CI: 1.88–2.20) with significant heterogeneity (I2 =82.7%, P=0.000). 4 studies with a total of 5,762 patients reported that the all-cause mortality did not differ between the PKD patients on PD and HD (RR: 0.87, 95%CI: 0.72-1.06). Conclusion: Our meta-analysis found that the outcomes of given population of PKD patients on PD were at least not inferior as compared to those with other primary kidney diseases, and suggested that PKD might be not absolutely a contraindication for PD. Given the limitations of the proposed, it needs further large-scale studies to assess whether PD is a suitable RRT option for end-stage renal disease (ESRD) patients with PKD.

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Peritoneal Dialysis in Special Situations

Nobakht¹,

Romero

Yin³

2021

Applied Peritoneal Dialysis

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Peritoneal Dialysis can be an Option for Dominant Polycystic Kidney Disease: An Observational Study

Cited by 22 publications

References 20 publications

Peritoneal dialysis for autosomal dominant polycystic kidney disease: a retrospective study

Peritoneal dialysis for autosomal dominant polycystic kidney disease: a retrospective study

Is Peritoneal Dialysis a Suitable Renal Replacement Therapy Option for Polycystic Kidney Disease Patients?

Peritoneal Dialysis in Special Situations

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