Peritoneal dialysis: A clinical study of factors governing its effectiveness

Boen, S. T.

doi:10.1038/sj.ki.5002633

Cited by 8 publications

(9 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As consistently demonstrated in many publications about the use of PD in acute kidney injury and nowadays in urgent ESRD patients, PD is a safe option of RRT start even in life-threatening conditions with secure and satisfactory results when performed by a dedicated and well-prepared team. [14][15][16][17] In our institution, after almost three years, the number of patients increased 2.2 fold and prevalence of patients on PD compared to HD almost doubled (from 15 to 27%). In Brazil in 2017, only 6.9% of prevalent patients on chronic dialysis were on PD.…”

Section: Resultsmentioning

confidence: 73%

Urgent vs. early-start peritoneal dialysis: patients' profile and outcomes

et al. 2021

View full text Add to dashboard Cite

ABSTRACT Introduction: Peritoneal dialysis (PD) has been considered a safe option of therapy in end-stage renal disease patients with urgent need of dialysis. Recently, it was proposed that Urgent-Start-PD (US-PD) be defined when PD starts within 72 hours after catheter placement and “early start” PD (ES-PD) when PD starts between 3 and 14 days after. We aimed to compare demographic and clinical characteristics between patients in US-PD and ES-PD as well as 30-day complications, 6-month hospitalization, and dropout rate. Methods: Adult patients starting PD within 14 days after catheter insertion (October/2016 - February/2019) were included and divided into US-PD group and ES-PD group based on the their PD initiation time. Clinical and demographic data, fill volume for the first PD session, 30-day complications, 6-month hospitalization, and dropout rate were assessed. Results: In our study, 72 patients were analyzed (US-PD=40, ES-PD=32) with mean age of 53.2±15.2 years old. No differences between US-PD and ES-PD regarding demographic characteristics, 30-day complications, 6-month hospitalization, and dropout events were found. The most frequent short-term complication in patients who started PD urgently was leakage. The most common cause of dropout was transfer to HD. Conclusion: Fifty five percent of our sample started PD less than 72 hours after catheter insertion. The lack of difference in the measured outcomes compared to patients that had therapy initiated after this period encourages the use of urgent PD when needed.

show abstract

Section: Resultsmentioning

confidence: 73%

Urgent vs. early-start peritoneal dialysis: patients' profile and outcomes

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Few studies have been published on PD in AKI, and metabolic implications were not evaluated in most (12,13).…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, daily protein loss was 4.23 ± 2.44 g, lower than reported elsewhere. Previous studies showed that daily protein loss into dialysate may reach 48 g in patients with AKI treated with intermittent PD (12,(22)(23)(24). In India, Chitalia et al (13) performed a prospective, randomized study that evaluated 2 modes of automated PD-continuous and tidal-in patients with AKI.…”

Section: Discussionmentioning

confidence: 99%

Metabolic Implications of Peritoneal Dialysis in Patients with Acute Kidney Injury

et al. 2013

View full text Add to dashboard Cite

♦ Background: Peritoneal dialysis (PD) is a treatment for selected acute kidney injury patients (AKI), but little is known about its metabolic implications. The aim of the present study was to evaluate the metabolic implications of glucose absorption, sodium removal, protein loss into the dialysate, and catabolism in AKI patients undergoing high-volume PD and to identify risk factors associated with those metabolic effects.

show abstract

“…Vasoconstriction by intraperitoneal epinephrine decreased the absorption rates. Boen [ 6 , 7 ] was the first person to describe these crystalloid osmotic effects in patients with acute renal failure who were treated with peritoneal dialysis. It appeared that the addition of 2.5–4% glucose to an isotonic dialysis solution induced the removal of water from the body.…”

Section: Mechanisms Of Fluid Transport and An Assessment In Patientsmentioning

confidence: 99%

Peritoneal dialysis: from bench to bedside

Krediet

2013

Clinical Kidney Journal

View full text Add to dashboard Cite

Peritoneal dialysis was first employed in patients with acute renal failure in the 1940s and since the 1960s for those with end-stage renal disease. Its popularity increased enormously after the introduction of continuous ambulatory peritoneal dialysis in the end of 1970s. This stimulated both clinical and basic research. In an ideal situation, this should lead to cross-fertilization between the two. The present review describes two examples of interactions: one where it worked out very well and another where basic science missed the link with clinical findings. Those on fluid transport are examples of how old physiological findings on absorption of saline and glucose solutions were adopted in peritoneal dialysis by the use of glucose as an osmotic agent. The mechanism behind this in patients was first solved mathematically by the assumption of ultrasmall intracellular pores allowing water transport only. At the same time, basic science discovered the water channel aquaporin-1 (AQP-1), and a few years later, studies in transgenic mice confirmed that AQP-1 was the ultrasmall pore. In clinical medicine, this led to its assessment in patients and the notion of its impairment. Drugs for treatment have been developed. Research on biocompatibility is not a success story. Basic science has focussed on dialysis solutions with a low pH and lactate, and effects of glucose degradation products, although the first is irrelevant in patients and effects of continuous exposure to high glucose concentrations were largely neglected. Industry believed the bench more than the bedside, resulting in ‘biocompatible’ dialysis solutions. These solutions have some beneficial effects, but are evidently not the final answer.

show abstract

Peritoneal dialysis: A clinical study of factors governing its effectiveness

Cited by 8 publications

References 7 publications

Urgent vs. early-start peritoneal dialysis: patients' profile and outcomes

Urgent vs. early-start peritoneal dialysis: patients' profile and outcomes

Metabolic Implications of Peritoneal Dialysis in Patients with Acute Kidney Injury

Peritoneal dialysis: from bench to bedside

Contact Info

Product

Resources

About