Peritoneal and Systemic Inflammatory Mediators of Laparoscopic Bowel Injury in a Rabbit Model

Abstract

Laparoscopic surgery seems to be unable to sustain peritoneal immune responses, which may mask reliable clinical signs and symptoms of peritonitis associated with bowel injury.

Laparoscopic bowel injury in an animal model: monocyte migration and apoptosis

“…However, these differences are unlikely to be clinically significant (e.g., narrow variation, see later). Accordingly, previous studies from our laboratory showed that pneumoperitoneum alone and open midline laparotomy without bowel injury did not produce statistically significant differences in systemic and peritoneal white blood cell counts [9].…”

Small Exotic Animal Endosurgery

“…This appears due to the fact that less of an inflammatory response occurs with the minimally invasive nature of laparoscopy (Aldana et al, 2003;El-Hakim et al, 2004, 2005. In contrast to rabbits with intestinal leakage deteriorating within 12-24 h of open surgery, clinical impairment may be delayed for 2-3 days in rabbits undergoing laparoscopy.…”

Laparoscopic bowel injury: role of the site and the instrument type: study with an animal model

“…Therefore, the education and training for minimal invasive techniques must pay intense attention to prevention, recognition, and treatment of these complications. Unrecognized bowel injury is a serious complication of laparoscopic surgery, with variable morbidity and [4,[5][6][7][8][9]10]. The ''blind'' insertion of the Veress needle and the first trocar has proved to be responsible for many of these injuries.…”