Peritoneal Administration of Met-RANTES Attenuates Inflammatory and Nociceptive Responses in a Murine Neuropathic Pain Model

Liou, Jiin-Tarng; Mao, Chih-Chieh; Sum, Daniel Ching-Wah; Liu, Fu-Chao; Lai, Ying-Shu; Li, Jui-Chin; Day, Yuan-Ji

doi:10.1016/j.jpain.2012.09.015

Cited by 45 publications

(44 citation statements)

References 57 publications

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“…Some researchers have concluded that reducing CCL5 release, and thus diminishing inflammatory processes, may be a useful strategy for the treatment of neurodegenerative disorders in clinical settings. Liou et al (2013) demonstrated that daily peritoneal injection of Met-RANTES, which antagonizes the binding of CCL5 to CCR5, significantly attenuated thermal hyperalgesia and tactile allodynia induced by partial sciatic nerve ligation in mice. These data suggest that peripheral CCL5 is implicated in the processing of pain information (Liou et al, 2013).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Liou et al (2013) demonstrated that daily peritoneal injection of Met-RANTES, which antagonizes the binding of CCL5 to CCR5, significantly attenuated thermal hyperalgesia and tactile allodynia induced by partial sciatic nerve ligation in mice. These data suggest that peripheral CCL5 is implicated in the processing of pain information (Liou et al, 2013). We confirmed the up-regulation of CCL5 mRNA in the spinal cord and DRG, and we have revealed that MVC diminished these changes.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…CCL5 has been identified in injured nerves, which indicates a potential role in neuropathology (Liou et al, 2013;Oh et al, 2001). In addition, CCL5 acts as a ligand for the chemokine receptors CCR1, CCR3 and CCR5 and influences monocyte and T cell migration (Ajuebor et al, 2001;Bless et al, 2000).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Additionally, intraperitoneal (i.p.) administration of these two chemokines induces pain behaviors, and this effect might be evoked by CCR5 activation in the dorsal root ganglia (DRG) (Liou et al, 2013). Lee et al (2013) described that CCR5-knockout mice respond less to nociceptive stimuli than wild type mice.…”

Section: Introductionmentioning

confidence: 99%

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Beneficial properties of maraviroc on neuropathic pain development and opioid effectiveness in rats

Kwiatkowski

Piotrowska

Rojewska

et al. 2016

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Beneficial properties of maraviroc on neuropathic pain development and opioid effectiveness in rats

Kwiatkowski

Piotrowska

Rojewska

et al. 2016

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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“…Because the Ccl5 antagonist Met-RANTES has been used in vivo in animal models of atherosclerosis, we determined the protocol of Met-RANTES treatment according to previous reports (18)(19)(20) with minor modifications. Met-RANTES (R&D Systems, Minneapolis, MN) was administered i.p.…”

Section: Fk565 Administration and Met-rantes Treatmentmentioning

confidence: 99%

Activation of an Innate Immune Receptor, Nod1, Accelerates Atherogenesis in Apoe−/− Mice

Kanno

Nishio

Tanaka

et al. 2015

The Journal of Immunology

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Atherosclerosis is essentially a vascular inflammatory process in the presence of an excess amount of lipid. We have recently reported that oral administration of a nucleotide-binding oligomerization domain (Nod)-1 ligand, FK565, induced vascular inflammation in vivo. No studies, however, have proven the association between Nod1 and atherosclerosis in vivo. To investigate a potential role of NOD1 in atherogenesis, we orally administered FK565 to apolipoprotein E knockout (Apoe−/−) mice for 4 wk intermittently and performed quantification of atherosclerotic lesions in aortic roots and aortas, immunohistochemical analyses, and microarray-based gene expression profiling of aortic roots. FK565 administration accelerated the development of atherosclerosis in Apoe−/− mice, and the effect was dependent on Nod1 in non–bone marrow origin cells by bone marrow transplantation experiments. Immunohistochemical studies revealed the increases in the accumulation of macrophages and CD3 T cells within the plaques in aortic roots. Gene expression analyses of aortic roots demonstrated a marked upregulation of the Ccl5 gene during early stage of atherogenesis, and the treatment with Ccl5 antagonist significantly inhibited the acceleration of atherosclerosis in FK565-administered Apoe−/− mice. Additionally, as compared with Apoe−/− mice, Apoe and Nod1 double-knockout mice showed reduced development of atherosclerotic lesions from the early stage as well as their delayed progression and a significant reduction in Ccl5 mRNA levels at 9 wk of age. Data in the present study show that the Nod1 signaling pathway in non–bone marrow-derived cells contributes to the development of atherosclerosis.

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IL-10 Signaling in the Tumor Microenvironment of Ovarian Cancer

Batchu

Gruzdyn

Kolli

et al. 2021

Advances in Experimental Medicine and Biology

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Peritoneal Administration of Met-RANTES Attenuates Inflammatory and Nociceptive Responses in a Murine Neuropathic Pain Model

Cited by 45 publications

References 57 publications

Beneficial properties of maraviroc on neuropathic pain development and opioid effectiveness in rats

Beneficial properties of maraviroc on neuropathic pain development and opioid effectiveness in rats

Activation of an Innate Immune Receptor, Nod1, Accelerates Atherogenesis in Apoe−/− Mice

IL-10 Signaling in the Tumor Microenvironment of Ovarian Cancer

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