Perisynaptic schwann cells - The multitasking cells at the developing neuromuscular junctions

Álvarez-Suárez, Paloma; Gawor, Marta; Prószyński, Tomasz J.

doi:10.1016/j.semcdb.2020.02.011

Cited by 31 publications

(27 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although several myelinating and nonmyelinating cell types (Remak and terminal Schwann cells) have been associated with neuron regeneration, a defined molecular signature able to discriminate between subpopulations from different anatomical location and different functional specialization has not been clearly identified. Indeed, the molecular features of terminal Schwann cells remain mostly unknown, because their scarcity has so far impeded a comprehensive analysis ( 43 ). Our data indicate that scRNA-Seq–based approaches may circumvent this issue owing to their potential to identify transcriptional signatures in a small number of cells within the pool of cells analyzed.…”

Section: Discussionmentioning

confidence: 99%

Activation of skeletal muscle–resident glial cells upon nerve injury

Proietti¹,

Giordani²,

Bardi³

et al. 2021

JCI Insight

View full text Add to dashboard Cite

Here, we report on the identification of Itga7-expressing muscle resident glial cells activated by loss of NMJ integrity. Gene expression analysis at bulk and single cell level revealed that these cells are distinct from Itga7-expressing muscle satellite cells. We show that a selective activation and expansion of Itga7-positive glial cells occurs in response to muscle nerve lesion. Upon activation, muscle glial-derived progenies expressed neurotrophic genes, including Ngfr, which enables their isolation by FACS. We show that activated muscle glial cells also expressed genes potentially implicated in ECM remodeling at NMJs. Among them, we observed Tenascin C (Tnc), which was highly expressed by muscle glial cells activated upon nerve injury, and preferentially localized to NMJ. Interestingly, we observed that while the activation of muscle glial cells by acute nerve injury was reversible, upon NMJ repair. By contrast, in a mouse model of Amyotrophic Lateral Sclerosis (ALS), in which NMJ degeneration is progressive, muscle glial cells steadily increased over the course of the disease; however, they exhibited an impaired neurotrophic activity, suggesting that pathogenic activation of glial cells may be implicated in ALS progression.

show abstract

Section: Discussionmentioning

confidence: 99%

Activation of skeletal muscle–resident glial cells upon nerve injury

Proietti¹,

Giordani²,

Bardi³

et al. 2021

JCI Insight

View full text Add to dashboard Cite

show abstract

“…The communication between muscle and nerve depends on the neuromuscular junction, a synaptic connection where nerve ending contacts muscle fibers [37]. The neuromuscular junction is compose of nerve terminal, muscle fiber, and the non-myelinating Schwann cells, transmitting acetylcholine from neuron terminals to receptors on muscle fibers in interstitial space [38]. Drugs by interstitial administration may directly influence signal transmission or give another feedback to nervous system, resulting in immunoregulation in response to nerve activation.…”

Section: Discussionmentioning

confidence: 99%

Neglected interstitial space in malaria recurrence and treatment

Zhang

et al. 2020

Nano Res.

View full text Add to dashboard Cite

The interstitial space, a widespread fluid-filled compartment throughout the body, is related to many pathophysiological alterations and diseases, attracting increasing attention. The vital role of interstitial space in malaria infection and treatment has been neglected current research efforts. We confirmed the reinfection capacity of parasites sequestrated in interstitial space, which replenish the mechanism of recurrence. Malaria parasite-infected mice were treated with artemisinin-loaded liposomes through the interstitial space and exhibited a better therapeutic response. Notably, compared with oral administration, interstitial administration showed an unexpectedly high activation and recruitment of immune cells, and resulted in better clearance of sequestered parasites from organs, and enhanced pathological recovery. The interstitial route of administration prolongs the blood circulation time of artemisinin and increases its plasma concentration, and may compensate for the inefficiency of oral administration and the nanotoxicity of intravenous administration, providing a potential strategy for infectious disease therapy.

show abstract

“…The NMJ presents a characteristic pretzel-like structure [14] which is composed of five essential elements: (i) presynaptic motor nerve terminals; (ii) postsynaptic endplates in muscle fiber membranes (where acetylcholine receptors -AChRsare anchored); (iii) basal lamina, the extracellular matrix located in the synaptic cleft [20,21]; (iv) terminal Schwann cells (tSCs), which cover the nerve-muscle junctions (2-5 tSCs per NMJ) [22,23], and (v) fibroblast-like cells known as kranocytes or perisynaptic fibroblasts, which cap the NMJs from above the tSCs, thus covering the end-plate area in its entirety [24,25]. Of these NMJ components, kranocytes are currently the least studied.…”

Section: Introductionmentioning

confidence: 99%

Terminal Schwann Cell Aging: Implications for Age-Associated Neuromuscular Dysfunction

Fuertes-Álvarez¹,

Izeta²

2021

Aging and disease

View full text Add to dashboard Cite

Action potential is transmitted to muscle fibers through specialized synaptic interfaces called neuromuscular junctions (NMJs). These structures are capped by terminal Schwann cells (tSCs), which play essential roles during formation and maintenance of the NMJ. tSCs are implicated in the correct communication between nerves and muscles, and in reinnervation upon injury. During aging, loss of muscle mass and strength (sarcopenia and dynapenia) are due, at least in part, to the progressive loss of contacts between muscle fibers and nerves. Despite the important role of tSCs in NMJ function, very little is known on their implication in the NMJ-aging process and in age-associated denervation. This review summarizes the current knowledge about the implication of tSCs in the age-associated degeneration of NMJs. We also speculate on the possible mechanisms underlying the observed phenotypes.

show abstract

Perisynaptic schwann cells - The multitasking cells at the developing neuromuscular junctions

Cited by 31 publications

References 81 publications

Activation of skeletal muscle–resident glial cells upon nerve injury

Activation of skeletal muscle–resident glial cells upon nerve injury

Neglected interstitial space in malaria recurrence and treatment

Terminal Schwann Cell Aging: Implications for Age-Associated Neuromuscular Dysfunction

Contact Info

Product

Resources

About