Perisurgical erythropoietin application in anemic patients with colorectal cancer: A double-blind randomized study

The Effects of Epoetin Alfa on Transfusion Requirements in Head and Neck Cancer Patients: A Prospective, Randomized, Placebo‐Controlled Study

“…Although a reduction in the requirement of perioperative allogeneic blood transfusions was not identified, both authors associated the short treatment interval and lack of iron availability with these negative findings. 48,49 …”

“… 37–45 Epoetin alfa has also been shown to stimulate erythropoiesis in patients undergoing oncologic tumor resection. 46–50 A recent prospective, non‐controlled study evaluating perioperative epoetin alfa therapy in 10 patients scheduled to undergo major head and neck cancer surgical resection found a significant increase from baseline to day‐of‐surgery HGB levels. Although not designed to demonstrate a reduction in transfusion rates, no patients in this study required a perioperative allogeneic blood transfusion.…”

Clinical Impact of Bioactive Substances in Blood Components: Implications for Leukocyte Filtration

“…It was shown that the hematocrit and the hemoglobin level could be reduced without increasing morbidity and mortality rates [146][147][148][149], and thus the use of normovolemic hemodilution should be encouraged [146,147]. Future attempts at reducing transfusion with allogeneic and predeposit autologous blood may depend on the clinical effectivity of bone marrow stimulating drugs [150,151], artificial blood products [152], and intraoperative and postoperative shed and reinfused autologous blood, at least in noncontaminated surgery for benign diseases [153][154][155].…”

Preoperative Administration of Recombinant Human Erythropoietin in Patients Undergoing Gynecologic Surgery

“…In the study by Braga et al [17], rHuEPO at a dose of 100 IU/kg was administered three times with an interval of 4 days prior to surgery. Heiss et al [18] administered 150 IU/kg of r-HuEPO every second day for 10 days before surgery and 150 IU/kg on the second postoperative day. With the regimen used in our study, individualized according to baseline preoperative Hb levels, significant stimulation of erythropoiesis was achieved in all groups of treated patients.…”