Peristat: A Computer-Based Perimetry Self-Test for Cost-Effective Population Screening of Glaucoma

Ianchulev, Tsontcho; Pham, P.; Makarov, Vladimir; Francis, Brian A.; Minckler, Don S.

doi:10.1080/02713680490522399

Cited by 25 publications

(38 citation statements)

References 10 publications

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“…Several programs have been developed for visual field examination using laptop or desktop computers [4][5][6] . Our interest was recently prompted by the online, inexpensive, and easy-to-use visual field test: the Damato Multifixation Campimetry Online (DMCO) [4] .…”

Section: Introductionmentioning

confidence: 99%

Can DMCO Detect Visual Field Loss in Neurological Patients? A Secondary Validation Study

Olsen

Steensberg²,

Cour

et al. 2017

Ophthalmic Res

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Unrecognized visual field loss is caused by a range of blinding eye conditions as well as serious brain diseases. The commonest cause of asymptomatic visual field loss is glaucoma. No screening tools have been proven cost-effective. Damato Multifixation Campimetry Online (DMCO), an inexpensive online test, has been evaluated as a future cost-beneficial tool to detect glaucoma. To further validate DMCO, this study aimed to test DMCO in a preselected population with neurological visual field loss. Methods: The study design was an evaluation of a diagnostic test. Patients were included if they had undergone surgery for epilepsy during 2011-2014, resulting in visual field loss. They were examined with DMCO and results were compared with those obtained with the Humphrey Field Analyzer (30:2 SITA-Fast). DMCO sensitivity and specificity were estimated with 95% confidence intervals. Results: The cohort comprised 40 patients (25 female and 15 male) with a mean age of 39 years (range 17-60 years). The mean visual acuity was >1.0 and all eyes had an intraocular pressure <21 mm Hg. Sensitivity and specificity of DMCO compared to the reference standard were 72.7 and 96.3%, respectively. Conclusions: DMCO detects moderate-to-severe homonymous quadrantanopia; it can be useful in settings where the current practice is confrontation visual field examination, and where standard conventional perimetry is not available.

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Section: Introductionmentioning

confidence: 99%

Can DMCO Detect Visual Field Loss in Neurological Patients? A Secondary Validation Study

Olsen

Steensberg²,

Cour

et al. 2017

Ophthalmic Res

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“…LL-37, the sole member of the human cathelicidin family is also expressed by corneal and conjunctival epithelial cells [18, 24]. This peptide is derived from a larger precursor, hCAP-18, and like hBD-2, its expression is upregulated in response to bacterial challenge [15-16, 25].…”

Section: Expression and Distribution Of Host-defence Peptides In Tmentioning

confidence: 99%

Role of host-defence peptides in eye diseases

Kolar

McDermott

2011

Cell. Mol. Life Sci.

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The eye and its associated tissues including the lacrimal system and lids have evolved several defence mechanisms to prevent microbial invasion. Included among this armory are several host-defence peptides. These multifunctional molecules are being studied not only for their endogenous antimicrobial properties but also for their potential therapeutic effects. Here the current knowledge of host-defence peptide expression in the eye will be summarized. The role of these peptides in eye disease will be discussed with the primary focus being on infectious keratitis, inflammatory conditions including dry eye and wound healing. Finally the potential of using host-defence peptides and their mimetics/derivatives for the treatment and prevention of eye diseases is addressed.

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“…Diabetic patients test their own blood glucose in order to adjust insulin dose [1] , and patients on anticoagulation medication test their international normalized ratio [2] . For assessing field loss in glaucoma patients, a computerbased FDA-registered perimetry device for self-testing by patients is available, which shows a high degree of correlation with the standard Humphrey visual-field analyzer [3] . In infectious medicine, self-testing has the potential to be an innovative component of HIV-prevention strategies in communities [4] .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a Self-Test Device Used in Allergic Contact Dermatitis

Elsner

Bjarnoe²,

Aberer

et al. 2015

Skin Pharmacol Physiol

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Considering the scarcity of dermatologic resources in many parts of the world, self-testing by patients is not only of interest for internal medicine but also for dermatology. In this open, nonrandomized, multicenter diagnostic trial involving subjects with suspected contact sensitization to nickel and/or a fragrance mix, we assessed the agreement of self-testing by subjects with readings made by dermatologists. The self-test product (Nixema^TM) is based on Thin-Layer Rapid Use Epicutaneous Test (TRUE Test®) technology. One hundred and sixty-five subjects self-tested the ready-made patch-test product. The test was applied for 48 h and then read after 3 or 4 days. It was also evaluated independently by experienced dermatologists after 3 or 4 days. In the 162 evaluable subjects, the proportion of agreement for both allergens together was 89.5% [95% confidence interval (CI) 83.7-93.8], the sensitivity was 97.5 % (95% CI 86.8-99.9) and the specificity was 86.9% (95% CI 79.6-92.3). Cohen's kappa was also high at 0.749 (95% CI 0.637-0.862). Discrepancies between the subjects' readings and the dermatologists' readings were mainly due to the subjects interpreting reactions of ‘irritant' or ‘doubtful' as ‘positive'. Apart from itching and burning sensations and tape irritation, no side effects were observed. In conclusion, this study showed a high rate of agreement between the self-reading of the upper arm and the readings made by the dermatologists. The upper arm proved to be an appropriate area for self-testing. Self-testing may improve the screening for contact sensitization for patients, particularly where dermatologic health resources are scarce.

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Peristat: A Computer-Based Perimetry Self-Test for Cost-Effective Population Screening of Glaucoma

Abstract: Peristat is a reliable self-test perimetry system that demonstrates high clinical utility for the detection of visual-field defects from glaucoma. Peristat could be a valuable public health tool for cost-effective screening of glaucoma.

Cited by 25 publications

References 10 publications

Can DMCO Detect Visual Field Loss in Neurological Patients? A Secondary Validation Study

Can DMCO Detect Visual Field Loss in Neurological Patients? A Secondary Validation Study

Role of host-defence peptides in eye diseases

Evaluation of a Self-Test Device Used in Allergic Contact Dermatitis

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