Perirhinal cortex lesions impair simultaneous but not serial feature-positive discrimination learning.

Campolattaro, Matthew M.; Freeman, John H.

doi:10.1037/0735-7044.120.4.970

Cited by 17 publications

(18 citation statements)

References 60 publications

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“…Based on these findings, the authors hypothesize that PER may play a role in resolving ambiguity in discriminations with overlapping stimulus elements (Campolattaro & Freeman, 2006b). Thus, it is possible that PER and RSP make unique contributions to complex learning paradigms by resolving stimulus ambiguity for overlapping stimulus elements and by forming or mediating associations between multiple stimuli, respectively.…”

Section: Discussionmentioning

confidence: 99%

Involvement of retrosplenial cortex in forming associations between multiple sensory stimuli.

Robinson

Keene²,

Iaccarino³

et al. 2011

Behavioral Neuroscience

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The retrosplenial cortex (RSP) is highly interconnected with medial temporal lobe structures, yet relatively little is known about its specific contributions to learning and memory. One possibility is that RSP is involved in forming associations between multiple sensory stimuli. Indeed, damage to RSP disrupts learning about spatial or contextual cues and also impairs learning about co-occurring conditioned stimuli (CSs). Two experiments were conducted to test this notion more rigorously. In Experiment 1, rats were trained in a serial feature negative discrimination task consisting of reinforced presentations of a tone alone and non-reinforced serial presentations of a light followed by the tone. Thus, in contrast to prior studies, this paradigm involved serial presentation of conditioned stimuli (CS), rather than simultaneous presentation. Rats with damage to RSP failed to acquire the discrimination, indicating that RSP is required for forming associations between sensory stimuli regardless of whether they occur serially or simultaneously. In Experiment 2, a sensory preconditioning task was used to determine if RSP was necessary for forming associations between stimuli even in the absence of reinforcement. During the first phase of this procedure, one auditory stimulus was paired with a light while a second auditory stimulus was presented alone. In the next phase of training, the same light was paired with food. During the final phase of the procedure both auditory stimuli were presented alone during a single session. Control, but not RSP-lesioned rats, exhibited more food cup behavior following presentation of the auditory cue that was previously paired with light compared to the unpaired auditory stimulus, indicating that a stimulus-stimulus association was formed during the first phase of training. These results support the idea that RSP has a fundamental role in forming associations between environmental stimuli.

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Section: Discussionmentioning

confidence: 99%

Involvement of retrosplenial cortex in forming associations between multiple sensory stimuli.

Robinson

Keene²,

Iaccarino³

et al. 2011

Behavioral Neuroscience

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show abstract

“…Rats with PER damage were impaired on a feature-negative task (LT+, T−) when the compound stimuli were presented simultaneously, but not when the compound was presented serially (L—>T+, T−, Campolattaro and Freeman, 2006a ). Rats with PER damage were also shown to be impaired on positive patterning (LT+, L−, T−) when the compounds were presented simultaneously (Campolattaro and Freeman, 2006b). Again, when the same stimuli were presented serially in the positive patterning task, PER damage did not cause deficits (Campolattaro and Freeman, 2006b).…”

Section: Discussionmentioning

confidence: 99%

“…Rats with PER damage were also shown to be impaired on positive patterning (LT+, L−, T−) when the compounds were presented simultaneously (Campolattaro and Freeman, 2006b). Again, when the same stimuli were presented serially in the positive patterning task, PER damage did not cause deficits (Campolattaro and Freeman, 2006b). Similar results were obtained with a purely visual task.…”

Section: Discussionmentioning

confidence: 99%

The effects of combined perirhinal and postrhinal damage on complex discrimination tasks

2012

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Rats with combined lesions of the perirhinal and postrhinal cortices were trained on a complex discrimination task, the simultaneous feature-positive and feature-negative discrimination task. In this task, a panel light (L) paired with an auditory stimulus determined whether a tone (T) or white noise (N) would be rewarded (+) or not rewarded (−). Thus, the light feature determined whether the target auditory stimuli were rewarded or not. In each session, trial types were LT+, T−, N+, and LN−. We had hypothesized that damage to the target regions would impair performance on this task. Acquisition was altered in the lesioned rats, but not in the predicted direction. Instead, lesioned rats exhibited significantly enhanced acquisition of the discrimination. Manipulation of intertrial intervals indicated that reduction of proactive interference did not explain the enhancement. Lesioned rats were not different from controls on a multiple cued-interval timing task, providing evidence that the enhancement does not extend to all types of discriminations and is not due to a deficit in timing. Other research shows that rats with perirhinal lesions are impaired on similar tasks, thus the enhancement is likely due to the effects of postrhinal damage. Normally in this task, context is thought to accrue inhibitory control over other cues. Without this inhibitory control, animals might be expected to learn the task more efficiently. Our conclusion is that deficits in processing contextual information underlie the enhanced acquisition observed in rats with combined perirhinal and postrhinal damage on this complex discrimination task.

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“…Lesions of this area that include ventral perirhinal cortex impair both simultaneous feature-positive discrimination learning, feature-negative discrimination learning, and sensory preconditioning using delay eyeblink paradigms (Campolattaro & Freeman, 2006a; Campolattaro & Freeman, 2006b; Nicholson & Freeman, 2000). Rabbits that underwent trace conditioning had increased c-Fos activity in perirhinal cortex during acquisition but not during maintenance performance (Jiménez-Díaz, Sancho-Bielsa, Gruart, & López-García, 2006).…”

Section: Discussionmentioning

confidence: 99%

Metabolic mapping of rat forebrain and midbrain during delay and trace eyeblink conditioning

Plakke

Freeman

Poremba

2009

Neurobiology of Learning and Memory

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While the essential neural circuitry for delay eyeblink conditioning has been largely identified, much of the neural circuitry for trace conditioning has yet to be determined. The major difference between delay and trace conditioning is a time gap between the presentation of the conditioned stimulus (CS) and the unconditioned stimulus (US) during trace conditioning. It is this time gap, which accounts for the additional memory component and may require extra neural structures, including hippocampus and prefrontal cortex. A metabolic marker of energy use, radioactively labeled glucose analog, was used to compare differences in glucose analog uptake between delay, trace, and unpaired experimental groups (rats, Long-Evans), to identify possible new areas of involvement within forebrain and midbrain. Here, we identify increased 2-DG uptake for the delay group compared to the unpaired group in various areas including: the medial geniculate nuclei (MGN), the amygdala, cingulate cortex, auditory cortex, medial dorsal thalamus, and frontal cortices. For the trace group, compared to the unpaired group, there was an increase in 2-DG uptake for the medial orbital frontal cortex and the medial MGN. The trace group also exhibited more increases lateralized to the right hemisphere, opposite to the side of US delivery, in various areas including: CA1, subiculum, presubiculum, perirhinal cortex, ventral and dorsal MGN, and the basolateral and central amygdala. While some of these areas have been identified as important for delay or trace conditioning, some new structures have been identified such as the orbital frontal cortex for both delay and trace groups.

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Perirhinal cortex lesions impair simultaneous but not serial feature-positive discrimination learning.

Cited by 17 publications

References 60 publications

Involvement of retrosplenial cortex in forming associations between multiple sensory stimuli.

Involvement of retrosplenial cortex in forming associations between multiple sensory stimuli.

The effects of combined perirhinal and postrhinal damage on complex discrimination tasks

Metabolic mapping of rat forebrain and midbrain during delay and trace eyeblink conditioning

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