Periprosthetic Joint Infections Treated with Two-Stage Revision over 14Years: An Evolving Microbiology Profile

Bjerke-Kroll, Benjamin T.; Christ, Alexander B.; McLawhorn, Alexander S.; Sculco, Peter K.; Jules-Elysée, Kethy M.; Sculco, Thomas P.

doi:10.1016/j.arth.2013.09.053

Cited by 96 publications

(93 citation statements)

References 47 publications

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“…Concerning streptococcal infections, our study confirms the importance of Streptococcus agalactiae and shows the existence of true PJIs caused by the Streptococcus mitis and Streptococcus milleri groups (26). P. acnes infections represented 7% of monomicrobial anaerobic PJIs, which highlights its role in the pathogenicity of implant-associated infections (27). Considering the performance of the 16S rRNA gene PCR assay according to the different bacteria, sensitivity was excellent for S. aureus and streptococci, poorer for CoNS, and bad for P. acnes, as only 11% of P. acnes and 72% of CoNS infections were detected by PCR, compared with 92% and 100% of S. aureus and streptococci, respectively.…”

Section: Discussionsupporting

confidence: 53%

Evaluation of 16S rRNA Gene PCR Sensitivity and Specificity for Diagnosis of Prosthetic Joint Infection: a Prospective Multicenter Cross-Sectional Study

Bémer¹,

et al. 2014

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There is no standard method for the diagnosis of prosthetic joint infection (PJI). The contribution of 16S rRNA gene PCR sequencing on a routine basis remains to be defined. We performed a prospective multicenter study to assess the contributions of 16S rRNA gene assays in PJI diagnosis. Over a 2-year period, all patients suspected to have PJIs and a few uninfected patients undergoing primary arthroplasty (control group) were included.

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Section: Discussionsupporting

confidence: 53%

Evaluation of 16S rRNA Gene PCR Sensitivity and Specificity for Diagnosis of Prosthetic Joint Infection: a Prospective Multicenter Cross-Sectional Study

Bémer¹,

et al. 2014

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“…Epidemiologic studies investigating various trends in the microbiological profile of PJI between two referral centers in Europe and the United States demonstrated that PJI caused by methicillin-resistant S. aureus is becoming increasingly prevalent (21,22). In the present case, growth of methicillin-resistant S. epidermidis was detected in blood and bone marrow cultures; however, a germiculture of joint fluid remained negative following various repeats.…”

Section: Discussionmentioning

confidence: 63%

Acute arrest of hematopoiesis induced by infection with Staphylococcus epidermidis following total knee arthroplasty: A case report and literature review

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. Infection is one of the most severe complications of total knee prosthesis implantation. The present study reported the case of a 74-year-old female that developed a Staphylococcus epidermidis infection following a cemented total knee arthroplasty. A routine blood test revealed neutropenia and anemia, while S. epidermidis was detected in the peripheral blood and bone marrow. In the present case, S. epidermidis infection led to acute arrest of hematopoiesis (AAH), also known as aplastic crisis, which is the temporary cessation of red cell production. The development of AAH secondary to S. epidermidis infection is rare and, to the best of our knowledge, this is the first case reported in the literature. The present study increased our knowledge of this rare disease and its characteristics, which will enable physicians to be aware of the development of AAH as a rare complication of S. epidermidis infection.

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“…Epidemiologic studies demonstrated different trends for microbiological profile of PJI between 2 referral centers in Germany and the United States [18] and for a single American institution over a period of 14 years [19]. These studies found that PJI caused by methicillin resistant Staphylococcus aureus (MRSA) is becoming more prevalent over time [19] and it is a more serious problem in the United States than in Germany [18].…”

Section: Microbiologymentioning

confidence: 99%

“…These studies found that PJI caused by methicillin resistant Staphylococcus aureus (MRSA) is becoming more prevalent over time [19] and it is a more serious problem in the United States than in Germany [18]. A multi-institutional study tracked the microbiological profile of 92 PJI cases, in which 2-stage exchange arthroplasty failed.…”

Section: Microbiologymentioning

confidence: 99%

Infection post-total knee replacement: current concepts

Alijanipour

Parvızı

2014

Curr Rev Musculoskelet Med

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Periprosthetic joint infection is a hot topic for investigation because it represents a challenging clinical problem with considerable burden for patients, institutions, and health systems. Despite our substantial knowledge, many details in prevention, pathophysiology, diagnosis, and treatment of infectious complications following total knee arthroplasty remain to be controversial with the available evidence being insufficient and at times conflictive. This manuscript is an attempt to approach the most recently published literature regarding the aforementioned details and aims to provide the reader with an updated perspective in the management of periprosthetic joint infection of the knee.

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Periprosthetic Joint Infections Treated with Two-Stage Revision over 14Years: An Evolving Microbiology Profile

Cited by 96 publications

References 47 publications

Evaluation of 16S rRNA Gene PCR Sensitivity and Specificity for Diagnosis of Prosthetic Joint Infection: a Prospective Multicenter Cross-Sectional Study

Evaluation of 16S rRNA Gene PCR Sensitivity and Specificity for Diagnosis of Prosthetic Joint Infection: a Prospective Multicenter Cross-Sectional Study

Acute arrest of hematopoiesis induced by infection with Staphylococcus epidermidis following total knee arthroplasty: A case report and literature review

Infection post-total knee replacement: current concepts

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