Periprosthetic Joint Infection with Negative Culture Results: Clinical Characteristics and Treatment Outcome

Comparison of infection control rates and clinical outcomes in culture-positive and culture-negative infected total-knee arthroplasty

“…In the present study, incidence of negative culture result was 42% (102 of 242 knees), which was substantially higher compared to other published series in the literature. 6,7,37,38 We suggest that this finding may be explained by higher incidence of previous intravenous and oral antibiotic treatment, which was consistent with the previous reports. that the culture-negative group showed significantly higher treatment success rates compared to the culture-positive group.…”

One-stage revision of infected hip arthroplasty: outcome of 39 consecutive hips

“…According to IDSA guidelines, these patients would not qualify for one-stage exchange. However, Choi et al [21] showed that two-stage revision is not mandatory for all patients with no known preoperative microbiology. Nevertheless, in patients with unknown microbiology, the risk for failure is increased, since they may have PJI caused by difficult-to-treat microorganisms, such as small-colony variants [22].…”

CORR Insights®: Does Preoperative Antimicrobial Prophylaxis Influence the Diagnostic Potential of Periprosthetic Tissues in Hip or Knee Infections?

“…For an established PJI caused by an unknown microorganism, twostage exchange remains the standard treatment option in order to give an appropriate therapy before reimplantation [4]. However, there is increasing evidence that one-stage exchange can be a reliable and safe procedure even in these cases, provided that there is a low probability of infection with difficultto-treat pathogens [2].…”